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NPY1R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F1U, 2IIL
Identifiers
Aliases	NPY1R, NPY1-R, NPYR, Neuropeptide Y receptor Y1
External IDs	OMIM: 162641; MGI: 104963; HomoloGene: 700; GeneCards: NPY1R; OMA:NPY1R - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	163,344,832 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	67,159,444 bp
RNA expression pattern
	Top expressed in
	spleen; ; popliteal artery; ; tibial arteries; ; right adrenal cortex; ; left adrenal cortex; ; Descending thoracic aorta; ; adipose tissue; ; germinal epithelium; ; superficial temporal artery; ; subcutaneous adipose tissue;
	Top expressed in
	ascending aorta; ; aortic valve; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; trigeminal ganglion; ; muscle of thigh; ; hippocampus proper; ; posterior horn of spinal cord; ; spinal ganglia;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neuropeptide Y receptor activity; G protein-coupled receptor activity; signal transducer activity; protein binding; peptide YY receptor activity; pancreatic polypeptide receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane;
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; locomotory behavior; regulation of multicellular organism growth; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; outflow tract morphogenesis; blood circulation; regulation of blood pressure; feeding behavior; glucose metabolic process; sensory perception of pain; neuropeptide signaling pathway; signal transduction; chemical synaptic transmission; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4886
	18166
	ENSG00000164128
	ENSMUSG00000036437
	P25929
	Q04573
	NM_000909
	NM_010934; NM_001358955
	NP_000900
	NP_035064; NP_001345884
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.^[5]^[6]

Selective ligands

Agonists

Neuropeptide Y (endogenous agonist, non subtype selective)
Peptide YY

Antagonists

Peptide

BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

BIBO-3304 (CAS# 191868-14-1)
BIBP-3226 (CAS# 159013-54-4)
PD-160,170 (CAS# 181468-88-2)

Available Structures

5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)^[7]
5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164128 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036437 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. doi:10.1016/S0021-9258(18)53306-8. PMID 8095935.
^ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".
^ ^a ^b Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.

External links

"Neuropeptide Y Receptors: Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
Overview of all the structural information available in the PDB for UniProt: P25929 (Neuropeptide Y receptor type 1) at the PDBe-KB.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164128 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036437 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8095935-5] Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. doi:10.1016/S0021-9258(18)53306-8. PMID 8095935.

[entrez-6] "Entrez Gene: NPY1R neuropeptide Y receptor Y1".

[:0-7] Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.

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PROFILPELAJAR.COM

Neuropeptide Y receptor Y1

Selective ligands

Agonists

Antagonists

Available Structures

See also

References

Further reading

External links