GPR12

GPR12
Identifiers
AliasesGPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDsOMIM: 600752; MGI: 101909; HomoloGene: 3868; GeneCards: GPR12; OMA:GPR12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2835

14738

Ensembl

ENSG00000132975

ENSMUSG00000041468

UniProt

P47775

P35412

RefSeq (mRNA)

NM_005288

RefSeq (protein)

NP_005279

Location (UCSC)Chr 13: 26.76 – 26.76 MbChr 5: 146.52 – 146.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.[5][6][7]

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.[8]

Ligands

Inverse agonists

Evolution

Paralogues

Source:[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132975 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041468 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Letters. 336 (2): 317–22. doi:10.1016/0014-5793(93)80828-I. PMID 8262253. S2CID 31345248.
  6. ^ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
  7. ^ "Entrez Gene: GPR12 G protein-coupled receptor 12".
  8. ^ Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–66. doi:10.1016/j.bbrc.2006.07.090. PMID 16887097.
  9. ^ Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12". Biochemical and Biophysical Research Communications. 493 (1): 451–454. doi:10.1016/j.bbrc.2017.09.001. PMC 5849771. PMID 28888984.
  10. ^ "GeneCards®: The Human Gene Database".

Further reading

  • Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592. S2CID 45156405.
Stub icon

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

Read other articles:

The Eye (film 2002)

The EyePoster film Hong KongNama lainTradisional見鬼Sederhana见鬼MandarinJiàn GuǐKantonGin3 Gwai2 SutradaraDanny Pang PhatOxide Pang ChunProduserPeter ChanLawrence ChengJojo HuiEric TsangDitulis olehJojo HuiDanny Pang PhatOxide Pang ChunPemeranAngelica LeeLawrence ChouChutcha RujinanonPenata musikOrange MusicSinematograferDecha SeementaPenyuntingDanny Pang PhatOxide Pang ChunPerusahaanproduksiApplause PicturesDistributorMediacorp Raintree PicturesTanggal rilis 9 Mei 2002...

 

 

Artibeus lituratus

Come leggere il tassoboxGrande artibeo Stato di conservazione Rischio minimo[1] Classificazione scientifica Dominio Eukaryota Regno Animalia Phylum Chordata Classe Mammalia Superordine Laurasiatheria Ordine Chiroptera Sottordine Microchiroptera Famiglia Phyllostomidae Sottofamiglia Stenodermatinae Tribù Stenodermatini Genere Artibeus Sottogenere Artibeus Specie A.lituratus Nomenclatura binomiale Artibeus lituratusOlfers, 1818 Sinonimi A.dominicanus, A.frenatus, A.rusbyi, A.supercili...

 

 

David Lowery

David LoweryDavid Lowery di acara Deauville Film Festival tahun 2013Lahir26 Desember 1980 (umur 43)[1]Milwaukee, Wisconsin[2]PendidikanIrving High School, Irving, TexasPekerjaanAktor, sutradara, produserSuami/istriAugustine Frizzell[3] David Lowery (lahir tanggal 26 Desember 1980) merupakan seorang aktor, produser dan sutradara film Amerika Serikat.[4] Ia dikenal sebagai sutradara film Ain't Them Bodies Saints (2013),[5] Pete's Dragon (2016) dan A...

Intervensi Iran dalam Perang Saudara Suriah

Republik Islam Iran dan Republik Arab Suriah adalah sekutu strategis yang erat, dan Iran telah memberikan dukungan yang signifikan kepada pemerintah Suriah dalam Perang Saudara Suriah, termasuk dukungan logistik, teknis dan keuangan, serta pelatihan dan sejumlah pasukan tempur. Iran memandang kelangsungan hidup pemerintah Suriah sebagai hal yang penting bagi kepentingan regionalnya. Ketika pemberontakan berkembang menjadi Perang Saudara Suriah, semakin banyak laporan mengenai dukungan militer...

 

 

Daftar basilika di Guatemala

Katedral Basilika Minor Kristus Hitam dari Esquipulas, Esquipulas Ini adalah daftar basilika di Guatemala. Katolik Daftar basilika Gereja Katolik di Guatemala[1]: Katedral Basilika Minor Kristus Hitam dari Esquipulas, Esquipulas Basilika Bunda dari Rosario, Kota Guatemala Lihat juga Gereja Katolik Roma Gereja Katolik di Guatemala Daftar katedral di Guatemala Daftar basilika Referensi ^ Basilika di seluruh dunia lbsDaftar basilika di Amerika UtaraNegaraberdaulat Amerika Serikat Antigua...

 

 

Nasīb (poetry)

Arabic literary form Part of a series onArabic culture ArchitectureStyles Islamic Yemeni Nabataean Umayyad Abbasid Fatimid Moorish Mamluk Features Ablaq Alfiz Arabesque Arabic dome Banna'i Gardens Girih Horseshoe arch Howz Hypostyle Islamic calligraphy Islamic geometric patterns Islamic ornament Iwan Liwan Mashrabiya Riad Mosaic Multifoil arch Muqarnas Nagash painting Qadad Reflecting pool Riwaq Sahn Socarrat Stucco decoration Tadelakt Vaulting Voussoir Windcatcher Zellij Types Albarrana towe...

Wilhelm Filchner

Cet article est une ébauche concernant l’Antarctique. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Wilhelm FilchnerPortrait de Wilhelm FilchnerBiographieNaissance 13 septembre 1877MunichDécès 7 mai 1957 (à 79 ans)Zurich, SuisseNationalité allemandeFormation Académie de guerre de PrusseActivités Explorateur, chercheur, écrivain, voyageurAutres informationsMembre de Académie LéopoldineConflit P...

 

 

Swiss Re

Untuk Swiss Re Tower, London, lihat: 30 St Mary Axe Schweizerische Rückversicherungs-Gesellschaft AGJenisAktiengesellschaftKode emitenSIX: SRENMerah Muda OTC: SSREYIndustriJasa keuanganDidirikan19 Desember 1863KantorpusatZurich, SwissTokohkunciMichel M. Liès (CEO di Induk), Christian Mumenthaler (CEO Reasuransi) Walter Kielholz (Ketua), J. Eric Smith (Presiden dan CEO Swiss Re Americas),ProdukReasuransi, Asuransi, Manajemen asetPendapatanAS$ 33.624.000.000 (2012)[1]Laba bersihA...

 

 

On My Mind

On My MindSingel oleh Cody Simpsondari album Coast to CoastDirilis23 April 201123 Mei 2011 (iTunes)Direkam2011GenreTeen popDurasi3:45PenciptaJulie Frost, Fraser T. Smith, Mike Caren, Nasri Atweh On My Mind adalah singel penyanyi asal Australia, Cody Simpson. Lagu ini ditulis oleh Julie Frost, Fraser T. Smith, Mike Caren and Nasri Atweh. Lagu ini dirilis pada tanggal 23 April 2011 dan dirilis di iTunes pada tanggal 23 Mei 2011.[1] Daftar lagu Unduhan digital:[1] On My Mind - 3:...

Soham

This article is about the town in England. For other uses, see Soham (disambiguation). Human settlement in EnglandSohamRed Lion SquareSohamLocation within CambridgeshireArea8.2 sq mi (21 km2) [1]Population12,336 [2]• Density1,504/sq mi (581/km2)OS grid referenceL591732Civil parishSohamDistrictEast CambridgeshireShire countyCambridgeshireRegionEastCountryEnglandSovereign stateUnited KingdomPost townELYPostcode distri...

 

 

Kematian dan pemakaman Paus Yohanes Paulus II

Kematian dan pemakaman Paus Yohanes Paulus IIJenazah Paus Yohanes Paulus II ditampilkan secara umumTanggal2 April 2005; 19 tahun lalu (2005-04-02) (kematian)8 April 2005; 19 tahun lalu (2005-04-08) (pemakaman)LokasiIstana Apostolik, Vatikan (kematian)Basilika Santo Petrus, Vatikan (pemakaman)PartisipanDewan Kardinal (dipimpin oleh Kardinal Joseph Ratzinger), berbagai pejabat di seluruh dunia Pada tanggal 2 April 2005, Paus Yohanes Paulus II wafat pada usia 84 tahun. Pemakaman diadak...

 

 

Повітряні сили Збройних сил України

Ця стаття потребує додаткових посилань на джерела для поліпшення її перевірності. Будь ласка, допоможіть удосконалити цю статтю, додавши посилання на надійні (авторитетні) джерела. Зверніться на сторінку обговорення за поясненнями та допоможіть виправити недоліки. Мат...

Frank Guinta

American politician (born 1970) Frank GuintaMember of the U.S. House of Representativesfrom New Hampshire's 1st districtIn officeJanuary 3, 2015 – January 3, 2017Preceded byCarol Shea-PorterSucceeded byCarol Shea-PorterIn officeJanuary 3, 2011 – January 3, 2013Preceded byCarol Shea-PorterSucceeded byCarol Shea-Porter54th Mayor of ManchesterIn officeJanuary 3, 2006 – January 3, 2010Preceded byRobert A. BainesSucceeded byTed GatsasCity of Manchester ...

 

 

Shar Jackson

American actress (born 1976) Shar JacksonJackson in December 2007BornSharisse Jackson (1976-08-31) August 31, 1976 (age 47)Boston, Massachusetts, U.S.Occupation(s)Actress, singerYears active1993–presentPartner(s)Corey Jackson (1992–1995)Kevin Federline (2001–2004)Children4 Sharisse Jackson[1] (born August 31, 1976[2]) is an American actress. She is best known for her portrayal of Niecy Jackson on the UPN sitcom Moesha. She was crowned the winner of MTV reality ...

 

 

John Havlicek

American basketball player (1940–2019) John HavlicekHavlicek in the 1960sPersonal informationBorn(1940-04-08)April 8, 1940Martins Ferry, Ohio, U.S.DiedApril 25, 2019(2019-04-25) (aged 79)Jupiter, Florida, U.S.Listed height6 ft 5 in (1.96 m)Listed weight203 lb (92 kg)Career informationHigh schoolBridgeport (Bridgeport, Ohio)CollegeOhio State (1959–1962)NBA draft1962: 1st round, 7th overall pickSelected by the Boston CelticsPlaying career1962–1978PositionSmal...

Pentakis dodecahedron

Catalan solid with 60 faces Pentakis dodecahedron (Click here for rotating model) Type Catalan solid Coxeter diagram Conway notation kD Face type V5.6.6isosceles triangle Faces 60 Edges 90 Vertices 32 Vertices by type 20{6}+12{5} Symmetry group Ih, H3, [5,3], (*532) Rotation group I, [5,3]+, (532) Dihedral angle 156°43′07″arccos(−80 + 9√5/109) Properties convex, face-transitive Truncated icosahedron(dual polyhedron) Net 3D model of a pentakis dodecahedron In geometry, a pentakis dode...

 

 

Тензор напряжений

Полный тензор механического напряжения элементарного объёма тела. Те́нзор напряже́ний (иногда тензор напряжений Коши, тензор натяжений) — тензор второго ранга, описывающий механические напряжения в произвольной точке нагруженного тела, возникающих в этой точке при...

 

 

فريق الكلية العسكرية

فريق الكلية العسكرية البلد العراق  تعديل مصدري - تعديل   فريق الكلية العسكرية هو فريق رياضي عراقي سابق، مقره في العاصمة بغداد، تم تأسيسه عام 1937 باسم الكلية العسكرية الملكية، وفي عام 1958 تم تبديل الاسم إلى فريق الكلية العسكرية، تم حله عام 1991 مع العديد من فرق الجيش الأخرى...

Gabriel Osson

Haitian-Canadian writer and broadcaster Gabriel OssonBornPort-au-Prince, HaitiOccupationnovelist, poetNationalityHaitian-CanadianPeriod2000s-presentNotable worksLe jour se lèvera Gabriel Osson is a Haitian-Canadian writer and broadcaster, whose novel Le jour se lèvera won the Prix Alain-Thomas from the Salon du livre de Toronto in 2021.[1] Originally from Port-au-Prince,[1] he is currently based in Toronto, Ontario, where he hosts the weekly world music show Franco découver...

 

 

電動アシスト自転車

警視庁の電動アシスト自転車 電動アシスト自転車（でんどうアシストじてんしゃ）とは、電動機（モーター）により人力を補助する自転車。搭乗者がペダルをこがなければ走行しない。 人力での電動補助のみならず、モーター単体のみで自走可能な自転車は電動自転車を参照。 概要 イギリスのEAPC、Thompson Electric Euro Classic 2 通常の自転車と原動機付自転車との中間的な...