Methuselah-like proteins

Methuselah N-terminus
Structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan[1]
Identifiers
SymbolMethuselah_N
PfamPF06652
InterProIPR010596
SCOP21fjr / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1fjr​

The Methuselah-like proteins are a family of G protein-coupled receptors found in insects that play a role in aging and reproduction. Antagonizing these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age dependent decline in olfaction and motor function is unaffected.[2]

Methuselah-like proteins are related to G protein-coupled receptors of the secretin receptor family.[1]

References

  1. ^ a b West AP, Llamas LL, Snow PM, Benzer S, Bjorkman PJ (March 2001). "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3744–9. Bibcode:2001PNAS...98.3744W. doi:10.1073/pnas.051625298. PMC 31123. PMID 11274391.
  2. ^ Alic N, Partridge L (2007). "Antagonizing Methuselah to extend life span". Genome Biology. 8 (8): 222. doi:10.1186/gb-2007-8-8-222. PMC 2374980. PMID 17764591.


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