GPR112

ADGRG4
Identifiers
AliasesADGRG4, PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4
External IDsMGI: 2685213; HomoloGene: 72131; GeneCards: ADGRG4; OMA:ADGRG4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

139378

236798

Ensembl

ENSG00000156920

ENSMUSG00000053852

UniProt

Q8IZF6

n/a

RefSeq (mRNA)

NM_153834

NM_001033327
NM_001110790
NM_001362885

RefSeq (protein)

NP_722576

n/a

Location (UCSC)Chr X: 136.3 – 136.42 MbChr X: 55.92 – 56.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene.[5][6] GPR112 is a member of the adhesion GPCR family.[7][8] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[9]

GPR112 is expressed in human enterochromaffin cells[10] and in the mouse intestine.[11] The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules.[11] GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156920 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053852 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPR112 G protein-coupled receptor 112".
  6. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
  7. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
  8. ^ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
  9. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
  10. ^ a b Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, et al. (February 2009). "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas". Modern Pathology. 22 (2): 261–272. doi:10.1038/modpathol.2008.174. PMID 18953328. S2CID 22334557.
  11. ^ a b Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.