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CD8A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AKJ, 1CD8, 1Q69, 2HP4, 3QZW
Identifiers
Aliases	CD8A, CD8, Leu2, MAL, p32, CD8a molecule
External IDs	OMIM: 186910; MGI: 88346; HomoloGene: 133777; GeneCards: CD8A; OMA:CD8A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	86,808,396 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	71,356,157 bp
RNA expression pattern
	Top expressed in
	thymus; ; spleen; ; granulocyte; ; blood; ; superficial temporal artery; ; lymph node; ; jejunal mucosa; ; appendix; ; bone marrow; ; bone marrow cells;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; blood; ; spleen; ; subcutaneous adipose tissue; ; duodenum; ; embryo; ; jejunum; ; sternocleidomastoid muscle; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	coreceptor activity; protein binding; MHC class I protein binding; protein kinase binding; MHC class I protein complex binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; T cell receptor complex; extracellular region; plasma membrane raft; external side of plasma membrane;
Biological process	antigen processing and presentation; adaptive immune response; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; immune response; regulation of immune response; T cell activation; T cell mediated immunity; cell surface receptor signaling pathway; cytotoxic T cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	925
	12525
	ENSG00000153563
	ENSMUSG00000053977
	P01732
	P01731
	NM_001145873; NM_001768; NM_171827
	NM_001081110; NM_009857
	NP_001139345; NP_001759; NP_741969; NP_001369627
	NP_001074579; NP_033987
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell surface glycoprotein CD8 alpha chain (Cluster of Differentiation 8a), is a protein encoded by CD8A gene.^[5]

Function

The CD8 protein is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen-presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to variable domain of immunoglobulin light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.^[5]

Interactions

CD8A has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153563 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053977 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CD8A CD8a molecule".
^ Doucey MA, Goffin L, Naeher D, Michielin O, Baumgärtner P, Guillaume P, Palmer E, Luescher IF (January 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5): 3257–64. doi:10.1074/jbc.M208119200. PMID 12215456.
^ ^a ^b Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI, Jones EY, Van Der Merwe PA, Bell JI, Jakobsen BK (May 2000). "Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha". J. Biol. Chem. 275 (20): 15232–8. doi:10.1074/jbc.275.20.15232. PMID 10809759.
^ Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK (June 1997). "Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2". Nature. 387 (6633): 630–4. Bibcode:1997Natur.387..630G. doi:10.1038/42523. PMID 9177355. S2CID 4267617.
^ Sanders SK, Giblin PA, Kavathas P (September 1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts". J. Exp. Med. 174 (3): 737–40. doi:10.1084/jem.174.3.737. PMC 2118947. PMID 1908512.

External links

CD8a+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD8A genome location and CD8A gene details page in the UCSC Genome Browser.
Human MAL genome location and MAL gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P01732 (Human T-cell surface glycoprotein CD8 alpha chain) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: P01731 (Mouse T-cell surface glycoprotein CD8 alpha chain) at the PDBe-KB.