Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4gene.[5][6][7]
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on monocytic cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. LILRB4 has also been proposed to be a potential target for tumor immunotherapy. It has been shown to express on tumor-associated macrophages and negatively regulate immune response in tumor.[8] The expression of LILRB4 on monocytic myeloid leukemia cells supports infiltration and inhibits T cell proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.[7]
^Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". Journal of Immunology. 162 (3): 1318–23. doi:10.4049/jimmunol.162.3.1318. PMID9973385.
Suciu-Foca N, Cortesini R (July 2007). "Central role of ILT3 in the T suppressor cell cascade". Cellular Immunology. 248 (1): 59–67. doi:10.1016/j.cellimm.2007.01.013. PMID17923119.
Arm JP, Nwankwo C, Austen KF (September 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". Journal of Immunology. 159 (5): 2342–9. doi:10.4049/jimmunol.159.5.2342. PMID9278324.
Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID9548455.
Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". Journal of Immunology. 162 (3): 1318–23. doi:10.4049/jimmunol.162.3.1318. PMID9973385.
Heinzmann A, Blattmann S, Forster J, Kuehr J, Deichmann KA (June 2000). "Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy". European Journal of Immunogenetics. 27 (3): 121–7. doi:10.1046/j.1365-2370.2000.00214.x. PMID10940079.
Liu WR, Kim J, Nwankwo C, Ashworth LK, Arm JP (July 2000). "Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4". Immunogenetics. 51 (8–9): 659–69. doi:10.1007/s002510000183. PMID10941837. S2CID23687483.
Young NT, Canavez F, Uhrberg M, Shum BP, Parham P (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID11491530. S2CID2819935.
Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, et al. (March 2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nature Immunology. 3 (3): 237–43. doi:10.1038/ni760. PMID11875462. S2CID35400503.
Garner LI, Salim M, Mohammed F, Willcox BE (June 2006). "Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies". Protein Expression and Purification. 47 (2): 490–7. doi:10.1016/j.pep.2005.11.020. PMID16406677.
