JAM2
Protein-coding gene in the species Homo sapiens
Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene .[ 5] [ 6] [ 7] CD322 (cluster of differentiation 322).
Function
Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space . The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells . It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs .[ 7]
It is purported to promote lymphocyte transendothelial migration.[ 8] cell polarity , by associating to cell polarity protein PARD3 (PAR-3), together with JAM3 .[ 9]
Interactions
JAM2 has been shown to interact with PARD3 .[ 9]
It also interacts with the integrin dimer VLA-4 (also called α4β1).[ 10]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000154721 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053062 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD (Aug 2000). "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells" . J Biol Chem . 275 (25): 19139–45. doi :10.1074/jbc.M003189200 PMID 10779521 . ^ Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (Nov 2000). "A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions" . J Biol Chem . 275 (44): 34750–6. doi :10.1074/jbc.M002718200 PMID 10945976 . ^ a b "Entrez Gene: JAM2 junctional adhesion molecule 2" .^ Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (October 2002). "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration" . Blood . 100 (7): 2479–86. doi :10.1182/blood-2001-11-0098 PMID 12239159 . ^ a b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity" . J. Cell Sci . 116 (Pt 19): 3879–91. doi :10.1242/jcs.00704 PMID 12953056 . ^ Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA (August 2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3" . J. Biol. Chem . 277 (31): 27589–92. doi :10.1074/jbc.C200331200 PMID 12070135 .
Further reading
Muller WA (2003). "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response". Trends Immunol . 24 (6): 327–34. doi :10.1016/S1471-4906(03)00117-0 . PMID 12810109 . Bazzoni G (2004). "The JAM family of junctional adhesion molecules". Curr. Opin. Cell Biol . 15 (5): 525–30. doi :10.1016/S0955-0674(03)00104-2 . PMID 14519386 . Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21" . Nature . 405 (6784): 311–9. Bibcode :2000Natur.405..311H . doi :10.1038/35012518 PMID 10830953 . Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Arrate MP, Rodriguez JM, Tran TM, et al. (2002). "Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor" . J. Biol. Chem . 276 (49): 45826–32. doi :10.1074/jbc.M105972200 PMID 11590146 . Liang TW, Chiu HH, Gurney A, et al. (2002). "Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3" . J. Immunol . 168 (4): 1618–26. doi :10.4049/jimmunol.168.4.1618 PMID 11823489 . Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics . 79 (6): 833–43. doi :10.1006/geno.2002.6782 . PMID 12036298 . Cunningham SA, Rodriguez JM, Arrate MP, et al. (2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3" . J. Biol. Chem . 277 (31): 27589–92. doi :10.1074/jbc.C200331200 PMID 12070135 . Aurrand-Lions M, Johnson-Leger C, Lamagna C, et al. (2004). "Junctional adhesion molecules and interendothelial junctions". Cells Tissues Organs (Print) . 172 (3): 152–60. doi :10.1159/000066967 . PMID 12476045 . S2CID 34211576 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ebnet K, Aurrand-Lions M, Kuhn A, et al. (2004). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity" . J. Cell Sci . 116 (Pt 19): 3879–91. doi :10.1242/jcs.00704 PMID 12953056 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites" . Protein Sci . 13 (10): 2819–24. doi :10.1110/ps.04682504 . PMC 2286551 PMID 15340161 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry" . J. Proteome Res . 4 (6): 2070–80. doi :10.1021/pr0502065 . PMC 1850943 PMID 16335952 .
External links
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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