4IFS
6749
20833
ENSG00000149136
ENSMUSG00000027067
Q08945
Q08943
NM_003146
NM_001136081NM_182990
NP_003137
NP_001129553NP_892035
FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene.[5]
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.[5]
Structure specific recognition protein 1 has been shown to interact with NEK9.[6] SSRP1 further interacts with transcriptional activator p63.[7] SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
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