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NFYC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N1J, 4AWL, 4CSR
Identifiers
Aliases	NFYC, CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC, nuclear transcription factor Y subunit gamma
External IDs	OMIM: 605344; MGI: 107901; HomoloGene: 7440; GeneCards: NFYC; OMA:NFYC - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	40,771,603 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	120,688,769 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; apex of heart; ; muscle of thigh; ; monocyte; ; tendon of biceps brachii; ; right lobe of thyroid gland; ; right auricle; ; gastrocnemius muscle; ; ganglionic eminence; ; skin of abdomen;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; genital tubercle; ; tail of embryo; ; thymus; ; heart; ; cerebellar cortex; ; bone marrow; ; olfactory bulb;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; sequence-specific DNA binding;
Cellular component	CCAAT-binding factor complex; protein-DNA complex; nucleus; nucleoplasm; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription by RNA polymerase II; protein folding; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of cholesterol biosynthetic process; negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	4802
	18046
	ENSG00000066136
	ENSMUSG00000032897
	Q13952
	P70353
NM_001142587; NM_001142588; NM_001142589; NM_001142590; NM_001308114;
	NM_001308115; NM_014223
NM_001048168; NM_001277095; NM_008692; NM_001357192; NM_001357193;
	NM_001357194
NP_001136059; NP_001136060; NP_001136061; NP_001136062; NP_001295043;
	NP_001295044; NP_055038
NP_001041633; NP_001264024; NP_032718; NP_001344121; NP_001344122;
	NP_001344123
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit (NFYB), a prerequisite for subunit A (NFYA) association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.^[7]

Two microRNAs; miR-30c and miR-30e are located within introns of the nfyc gene. These microRNAs are actively transcribed in human insulin-producing beta cells in the pancreatic islets that also show high expression of nfyc and CDH1 genes. The expression of these intronic microRNAs is essential for maintaining the differentiated phenotype of human islet beta cells. Inhibition of miR-30 family microRNAs induces epithelial-mesenchymal transition of human pancreatic islet cells.^[8]