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SIX2
Identifiers
Aliases	SIX2, SIX homeobox 2
External IDs	OMIM: 604994; MGI: 102778; HomoloGene: 56518; GeneCards: SIX2; OMA:SIX2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	45,009,452 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	85,995,702 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; gastrocnemius muscle; ; parotid gland; ; muscle of thigh; ; nasal epithelium; ; tendon of biceps brachii; ; testicle; ; tibialis anterior muscle; ; palpebral conjunctiva; ; pituitary gland;
	Top expressed in
	genital tubercle; ; vestibular membrane of cochlear duct; ; maxillary prominence; ; parotid gland; ; external carotid artery; ; vestibular sensory epithelium; ; internal carotid artery; ; urethra; ; utricle; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein-containing complex binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding;
Cellular component	nucleus; transcription regulator complex;
Biological process	embryonic skeletal system morphogenesis; regulation of chondrocyte differentiation; regulation of transcription, DNA-templated; positive regulation of chondrocyte proliferation; chondrocyte differentiation; protein import into nucleus; kidney development; negative regulation of cell differentiation; anatomical structure morphogenesis; mesenchymal stem cell maintenance involved in nephron morphogenesis; mesenchymal to epithelial transition involved in metanephros morphogenesis; mesenchymal cell differentiation involved in kidney development; mesenchymal stem cell proliferation; transcription by RNA polymerase II; regulation of branching involved in ureteric bud morphogenesis; multicellular organism development; nephron morphogenesis; nephron development; middle ear morphogenesis; embryonic digestive tract morphogenesis; embryonic cranial skeleton morphogenesis; regulation of ossification; cell population proliferation; mesodermal cell fate specification; anterior/posterior axis specification; metanephros development; cell migration; positive regulation of transcription by RNA polymerase II; condensed mesenchymal cell proliferation; negative regulation of transcription, DNA-templated; anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	10736
	20472
	ENSG00000170577
	ENSMUSG00000024134
	Q9NPC8; Q8TBA2
	Q62232
	NM_016932
	NM_011380
	NP_058628; NP_058628.3
	NP_035510
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX2 is a protein that in humans is encoded by the SIX2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170577 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024134 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SIX2 sine oculis homeobox homolog 2 (Drosophila)".
^ Oliver, Guillermo (1995). "Homeobox genes and connective tissue patterning" (PDF). Development. 121 (3): 693–705. doi:10.1242/dev.121.3.693. hdl:11858/00-001M-0000-0013-037D-E. PMID 7720577.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302.
Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759–66. doi:10.1128/MCB.22.19.6759-6766.2002. PMC 134036. PMID 12215533.
Buller C, Xu X, Marquis V, et al. (2002). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Hum. Mol. Genet. 10 (24): 2775–81. doi:10.1093/hmg/10.24.2775. PMID 11734542.
Boucher CA, Winchester CL, Hamilton GM, et al. (2000). "Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2". Gene. 247 (1–2): 145–51. doi:10.1016/S0378-1119(00)00105-0. PMID 10773454.
Celli J, van Beusekom E, Hennekam RC, et al. (2000). "Familial syndromic esophageal atresia maps to 2p23-p24". Am. J. Hum. Genet. 66 (2): 436–44. doi:10.1086/302779. PMC 1288096. PMID 10677303.
Kawakami K, Ohto H, Takizawa T, Saito T (1996). "Identification and expression of six family genes in mouse retina". FEBS Lett. 393 (2–3): 259–63. Bibcode:1996FEBSL.393..259K. doi:10.1016/0014-5793(96)00899-X. PMID 8814301. S2CID 20829948.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170577 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024134 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SIX2 sine oculis homeobox homolog 2 (Drosophila)".

[6] Oliver, Guillermo (1995). "Homeobox genes and connective tissue patterning" (PDF). Development. 121 (3): 693–705. doi:10.1242/dev.121.3.693. hdl:11858/00-001M-0000-0013-037D-E. PMID 7720577.

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SIX2

References

Further reading