863
12398
ENSG00000129993
ENSMUSG00000006362
O75081
O54972
NM_005187NM_175931
NM_001109873NM_009824NM_177289
NP_005178NP_787127
NP_001103343NP_033954NP_796263
Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded by the CBFA2T3 gene.[5][6]
The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.[6]
CBFA2T3 has been shown to interact with:
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.
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