1N4M
1870
242705
ENSG00000007968ENSG00000282899
ENSMUSG00000018983
Q14209
P56931
NM_004091
NM_177733NM_183301NM_001305399
NP_004082
NP_001292328NP_808401
Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[5][6]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[7]
E2F2 has been shown to interact with:
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
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