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HOXD11
Identifiers
Aliases	HOXD11, HOX4, HOX4F, homeobox D11
External IDs	OMIM: 142986; MGI: 96203; HomoloGene: 7368; GeneCards: HOXD11; OMA:HOXD11 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	176,109,754 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	74,517,360 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; stromal cell of endometrium; ; Achilles tendon; ; urethra; ; myometrium; ; muscle layer of sigmoid colon; ; gonad; ; vagina; ; ectocervix; ; decidua;
	Top expressed in
	tail of embryo; ; uterus; ; basal cell layer of epidermis; ; genital tubercle; ; granular layer of epidermis; ; urethra; ; male urethra; ; stroma of kidney; ; free upper limb; ; sclerotome;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	multicellular organism development; branching involved in ureteric bud morphogenesis; regulation of transcription, DNA-templated; dorsal/ventral pattern formation; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3237
	15431
	ENSG00000128713
	ENSMUSG00000042499
	P31277
	P23813
	NM_021192
	NM_008273
	NP_067015
	NP_032299
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.^[5]^[6]^[7]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.^[7]^[8]^[9]^[10]