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KLF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBT
Identifiers
Aliases	KLF5, BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5
External IDs	OMIM: 602903; MGI: 1338056; HomoloGene: 37520; GeneCards: KLF5; OMA:KLF5 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	73,077,541 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	99,552,472 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; gingival epithelium; ; human penis; ; mucosa of pharynx; ; amniotic fluid; ; mucosa of nose; ; mucosa of sigmoid colon; ; nipple; ; skin of abdomen; ; olfactory zone of nasal mucosa;
	Top expressed in
	left colon; ; crypt of lieberkuhn of small intestine; ; gastrula; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; migratory enteric neural crest cell; ; skin of external ear; ; conjunctival fornix; ; ileum; ; Paneth cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; nucleic acid binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; MRF binding;
Cellular component	Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; nucleus; transcription regulator complex;
Biological process	regulation of microvillus assembly; microvillus assembly; regulation of transcription, DNA-templated; intestinal epithelial cell development; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; angiogenesis; skeletal muscle cell differentiation; positive regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase II; cellular response to organic cyclic compound; positive regulation of cell population proliferation; cellular response to peptide; cellular response to leukemia inhibitory factor; cell-cell signaling via exosome; positive regulation of pri-miRNA transcription by RNA polymerase II; regulation of gene expression; skeletal muscle satellite cell differentiation; satellite cell activation involved in skeletal muscle regeneration; myotube differentiation involved in skeletal muscle regeneration; skeletal muscle tissue regeneration; positive regulation of transcription by transcription factor localization;
	Sources:Amigo / QuickGO
Orthologs
	688
	12224
	ENSG00000102554
	ENSMUSG00000005148
	Q13887
	Q9Z0Z7
	NM_001730; NM_001286818
	NM_009769
	NP_001273747; NP_001721
	NP_033899
	Wikidata
View/Edit Human	View/Edit Mouse

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.^[5]^[6]

Function

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.^[6]