YY1

YY1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UBD, 1ZNM, 4C5I
Identifiers
Aliases	YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS
External IDs	OMIM: 600013; MGI: 99150; HomoloGene: 2556; GeneCards: YY1; OMA:YY1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	100,282,788 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	108,786,074 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; rectum; ; monocyte; ; tonsil; ; sural nerve; ; skin of thigh;
	Top expressed in
	medullary collecting duct; ; primitive streak; ; ureter; ; renal corpuscle; ; Gonadal ridge; ; abdominal wall; ; left lung lobe; ; cumulus cell; ; human fetus; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; transcription coactivator activity; zinc ion binding; metal ion binding; protein binding; four-way junction DNA binding; cis-regulatory region sequence-specific DNA binding; RNA binding; nucleic acid binding; SMAD binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding;
Cellular component	Ino80 complex; nuclear matrix; nucleus; nucleoplasm; transcription regulator complex; cytoplasm; PcG protein complex;
Biological process	cell differentiation; DNA recombination; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; cellular response to UV; negative regulation of gene expression; transcription, DNA-templated; cellular response to DNA damage stimulus; double-strand break repair via homologous recombination; spermatogenesis; DNA repair; protein deubiquitination; negative regulation of interferon-beta production; negative regulation of transcription by RNA polymerase II; RNA localization; anterior/posterior pattern specification; response to UV-C; positive regulation of gene expression; response to prostaglandin F; positive regulation of transcription by RNA polymerase II; camera-type eye morphogenesis; chromosome organization; cellular response to interleukin-1; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of cell growth involved in cardiac muscle cell development;
	Sources:Amigo / QuickGO
Orthologs
	7528
	22632
	ENSG00000100811
	ENSMUSG00000021264
	P25490
	Q00899
	NM_003403
	NM_009537
	NP_003394
	NP_033563
	Wikidata
View/Edit Human	View/Edit Mouse

YY1 (Yin Yang 1)^[5] is a transcriptional repressor protein in humans that is encoded by the YY1 gene.^[6]^[7]

Function

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.^[8] YY1 promotes enhancer-promoter chromatin loops by forming dimers and promoting DNA interactions. Its dysregulation disrupts enhancer-promoter loops and gene expression.^[9]^[10]

Clinical significance

YY1 heterozygous deletions, missense, and nonsense mutations cause Gabriele-DeVries syndrome (GADEVS),^[11]^[12] an autosomal dominant neurodevelopmental disorder characterized by intellectual disability, dysmorphic facial features, feeding problems, intrauterine growth restriction, variable cognitive impairment, behavioral problems and other congenital malformations.^[10] A website is available in order to collect and share clinical information between clinicians and the families of affected individuals.^[13]

Interactions

YY1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100811 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021264 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.
^ Shi Y, Seto E, Chang LS, Shenk T (October 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. S2CID 19399858.
^ Zhu W, Lossie AC, Camper SA, Gumucio DL (April 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. hdl:2027.42/47010. PMID 7912122. S2CID 27296553.
^ "Entrez Gene: YY1 YY1 transcription factor".
^ Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, et al. (December 2017). "YY1 Is a Structural Regulator of Enhancer-Promoter Loops". Cell. 171 (7): 1573–1588.e28. doi:10.1016/j.cell.2017.11.008. PMC 5785279. PMID 29224777.
^ ^a ^b Gabriele M, Vulto-van Silfhout AT, Germain PL, Vitriolo A, Kumar R, Douglas E, et al. (June 2017). "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction". American Journal of Human Genetics. 100 (6): 907–925. doi:10.1016/j.ajhg.2017.05.006. PMC 5473733. PMID 28575647.
^ "Gabriele-de Vries Syndrome". OMIM.
^ Nabais Sá MJ, Gabriele M, Testa G, de Vries BB (1993). "Gabriele-de Vries Syndrome". In Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJ, Gripp KW, Amemiya A (eds.). GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle. PMID 31145572.
^ "YY1 – Collect information about clinic management and research projects". YY1.
^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, et al. (July 2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Molecular and Cellular Biology. 20 (14): 5096–106. doi:10.1128/mcb.20.14.5096-5106.2000. PMC 85959. PMID 10866666.
^ ^a ^b ^c Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Molecular and Cellular Biology. 21 (17): 5979–91. doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316. PMID 11486036.
^ Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, et al. (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.
^ Yang WM, Yao YL, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
^ ^a ^b Yang WM, Yao YL, Sun JM, Davie JR, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.
^ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
^ Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (December 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. Bibcode:1993Sci...262.1889S. doi:10.1126/science.8266081. PMID 8266081.
^ Yeh TS, Lin YM, Hsieh RH, Tseng MJ (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". The Journal of Biological Chemistry. 278 (43): 41963–9. doi:10.1074/jbc.M304353200. PMID 12913000.
^ García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
^ Huang NE, Lin CH, Lin YS, Yu WC (June 2003). "Modulation of YY1 activity by SAP30". Biochemical and Biophysical Research Communications. 306 (1): 267–75. doi:10.1016/s0006-291x(03)00966-5. PMID 12788099.
^ Fu CY, Wang P, Tsai HJ (November 2017). "Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis". Nucleic Acids Research. 45 (5): 2423–2437. doi:10.1093/nar/gkw1187. PMC 5389716. PMID 27913726.

External links

FactorBook YY1
Overview of all the structural information available in the PDB for UniProt: P25490 (Transcriptional repressor protein YY1) at the PDBe-KB.