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TAL2
Identifiers
Aliases	TAL2, TAL bHLH transcription factor 2
External IDs	OMIM: 186855; MGI: 99540; HomoloGene: 3954; GeneCards: TAL2; OMA:TAL2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	105,663,124 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	53,788,712 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; vastus lateralis muscle; ; buccal mucosa cell; ; muscle of thigh; ; deltoid muscle; ; renal medulla; ; ganglionic eminence; ; ventricular zone; ; gastrocnemius muscle;
	Top expressed in
	pineal gland; ; embryo; ; granulocyte; ; temporal muscle; ; spermatid; ; hair follicle; ; seminiferous tubule; ; muscle of thigh; ; skeletal muscle tissue; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; post-embryonic development; transcription, DNA-templated; midbrain development; multicellular organism growth; thalamus development; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6887
	21350
	ENSG00000186051
	ENSMUSG00000028417
	Q16559
	Q62282
	NM_005421
	NM_009317
	NP_005412
	NP_033343
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.^[5]^[6]

Function

Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).^[6]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186051 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028417 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2".
^ ^a ^b Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
^ Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol. 4 (6): 341–7. PMID 8142619.
^ Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187. S2CID 20213008.