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TLX3
Identifiers
Aliases	TLX3, HOX11L2, RNX, T-cell leukemia homeobox 3, T cell leukemia homeobox 3
External IDs	OMIM: 604640; MGI: 1351209; HomoloGene: 23181; GeneCards: TLX3; OMA:TLX3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	171,312,139 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	33,153,589 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; C1 segment; ; Pituitary Gland; ; anterior pituitary; ; olfactory zone of nasal mucosa; ; Cortex of frontal lobe; ; female reproductive system; ; oviduct; ; integument; ; zone of skin;
	Top expressed in
	lumbar spinal ganglion; ; urethra; ; female urethra; ; male urethra; ; neural tube; ; enteric nervous system; ; trigeminal ganglion; ; embryo; ; ganglion of vagus nerve; ; glossopharyngeal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nucleus; nucleoplasm;
Biological process	multicellular organism development; regulation of respiratory gaseous exchange by nervous system process; cell fate specification; neuron fate specification; central nervous system development; neuron migration; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; respiratory gaseous exchange by respiratory system; neuron differentiation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	30012
	27140
	ENSG00000164438
	ENSMUSG00000040610
	O43711
	O55144
	NM_021025
	NM_019916
	NP_066305
	NP_064300
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.^[5]^[6]^[7]

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164438 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040610 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee-Kirsch MA, Engel K, Paditz E, Rosen-Wolff A, Lee YA, Gahr M (Jul 2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping". Cytogenet Cell Genet. 92 (3–4): 358. doi:10.1159/000056933. PMID 11435718. S2CID 85323468.
^ Cinti R, Fava M, Sancandi M, Matera I, Ravazzolo R, Ceccherini I (Jul 2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization". Cytogenet Cell Genet. 92 (3–4): 354–5. doi:10.1159/000056931. PMID 11435716. S2CID 35224759.
^ ^a ^b "Entrez Gene: TLX3 T-cell leukemia homeobox 3".