KMT2A

KMT2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS, MLL-AF9, lysine methyltransferase 2A, Histone-lysine N-methyltransferase HRX, ALL1, HTRX
External IDsMGI: 96995; HomoloGene: 4338; GeneCards: KMT2A; OMA:KMT2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

4297

214162

Ensembl

ENSG00000118058

ENSMUSG00000002028

UniProt

Q03164

P55200

RefSeq (mRNA)

NM_001197104
NM_005933
NM_024891

NM_001081049
NM_001357549

RefSeq (protein)

NP_001184033
NP_005924

NP_001344478

Location (UCSC)Chr 11: 118.44 – 118.53 MbChr 9: 44.71 – 44.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone-lysine N-methyltransferase 2A, also known as acute lymphoblastic leukemia 1 (ALL-1), myeloid/lymphoid or mixed-lineage leukemia 1 (MLL1), or zinc finger protein HRX (HRX), is an enzyme that in humans is encoded by the KMT2A gene.[5]

MLL1 is a histone methyltransferase deemed a positive global regulator of gene transcription. This protein belongs to the group of histone-modifying enzymes comprising transactivation domain 9aaTAD[6] and is involved in the epigenetic maintenance of transcriptional memory. Its role as an epigenetic regulator of neuronal function is an ongoing area of research.

Function

Transcriptional regulation

KMT2A gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. Enriched in the nucleus, the MLL1 enzyme trimethylates H3K4 (H3K4me3). It also upregulates mono- and dimethylation of H3K4.[7] This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C (~180 kDa) and MLL-N (~320 kDa).[8][9] These fragments then assemble into different multi-protein complexes that regulate the transcription of specific target genes, including many of the HOX genes.

Transcriptome profiling after deletion of MLL1 in cortical neurons revealed decreased promoter-bound H3K4me3 peaks at 318 genes, with 31 of these having significantly decreased expression and promoter binding.[10] Among them were Meis2, a homeobox transcription factor critical for development of forebrain neurons[11][12] and Satb2, a protein involved in neuronal differentiation.[13]

Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[14]

Cognition and emotion

MLL1 has been shown to be an important epigenetic regulator of complex behaviors. Rodent models of MLL1 dysfunction in forebrain neurons showed that conditional deletion results in elevated anxiety and defective cognition. Prefrontal cortex-specific knockout of MLL1 results in the same phenotypes, as well as working memory deficits.[10]

Stem cells

MLL1 has been found to be an important regulator of epiblast-derived stem cells, post-implantation epiblast derived stem cells which display pluripotency yet many recognizable differences from the traditional embryonic stem cells derived from inner cell mass prior to implantation. Suppression of MLL1 expression was shown to be adequate for inducing ESC-like morphology and behavior within 72 hours of treatment. It has been proposed that the small molecule inhibitor MM-401, which was used to inhibit MLL1, changes the distribution of H3K4me1, the single methylation of the histone H3 lysine 4, to be significantly downregulated at MLL1 targets thus leading to decreased expression of MLL1 targets, rather than a direct regulation of pluripotency core markers.[15]

Structure

Gene

KMT2A gene has 37 exons and resides on chromosome 11 at q23.[14]

Protein

KMT2A has over a dozen binding partners and is cleaved into two pieces, a larger N-terminal fragment, involved in gene repression, and a smaller C-terminal fragment, which is a transcriptional activator.[16] The cleavage, followed by the association of the two fragments, is necessary for KMT2A to be fully active. Like many other methyltransferases, the KMT2 family members exist in multisubunit nuclear complexes (human COMPASS), where other subunits also mediate the enzymatic activity.[17]

9aaTADs in the E protein family E2A and MLL binding to the KIX domain of CBP

Clinical significance

Abnormal H3K4 trimethylation has been implicated in several neurological disorders such as autism.[18] Humans with cognitive and neurodevelopmental disease often have dysregulation of H3K4 methylation in prefrontal cortex (PFC) neurons.[18][19][20] It also may participate in the process of GAD67 downregulation in schizophrenia.[19]

MLL1 is required for the expression of senescence-associated secretory phenotype (SASP)-related genes and promotes increased inflammation.[21]

Rearrangements of the MLL1 gene are associated with aggressive acute leukemias, both lymphoblastic and myeloid.[22] Despite being an aggressive leukemia, the MLL1 rearranged sub-type had the lowest mutation rates reported for any cancer.[23]

Mutations in MLL1 cause Wiedemann-Steiner syndrome and acute lymphoblastic leukemia.[24] The leukemia cells of up to 80 percent of infants with ALL-1 have a chromosomal rearrangement that fuses the MLL1 gene to a gene on a different chromosome.[23]

Interactions

MLL (gene) has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118058 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002028 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ziemin-van der Poel S, McCabe NR, Gill HJ, Espinosa R, Patel Y, Harden A, et al. (December 1991). "Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias". Proceedings of the National Academy of Sciences of the United States of America. 88 (23): 10735–9. doi:10.1073/pnas.88.23.10735. PMC 53005. PMID 1720549.
  6. ^ Goto NK, Zor T, Martinez-Yamout M, Dyson HJ, Wright PE (November 2002). "Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain" (PDF). The Journal of Biological Chemistry. 277 (45): 43168–74. doi:10.1074/jbc.M207660200. PMID 12205094. S2CID 30354764.; Prasad R, Yano T, Sorio C, Nakamura T, Rallapalli R, Gu Y, et al. (December 1995). "Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia". Proceedings of the National Academy of Sciences of the United States of America. 92 (26): 12160–4. Bibcode:1995PNAS...9212160P. doi:10.1073/pnas.92.26.12160. PMC 40316. PMID 8618864.; Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ (April 2001). "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology. 21 (7): 2249–58. doi:10.1128/MCB.21.7.2249-2258.2001. PMC 86859. PMID 11259575.
  7. ^ Del Rizzo PA, Trievel RC (September 2011). "Substrate and product specificities of SET domain methyltransferases". Epigenetics. 6 (9): 1059–67. doi:10.4161/epi.6.9.16069. PMC 3225744. PMID 21847010.
  8. ^ Takeda S, Chen DY, Westergard TD, Fisher JK, Rubens JA, Sasagawa S, et al. (September 2006). "Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression". Genes & Development. 20 (17): 2397–409. doi:10.1101/gad.1449406. PMC 1560414. PMID 16951254.
  9. ^ Hsieh JJ, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ (January 2003). "Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization". Molecular and Cellular Biology. 23 (1): 186–94. doi:10.1128/MCB.23.1.186-194.2003. PMC 140678. PMID 12482972.
  10. ^ a b Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q, et al. (April 2015). "Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory". The Journal of Neuroscience. 35 (13): 5097–108. doi:10.1523/JNEUROSCI.3004-14.2015. PMC 4380991. PMID 25834037.
  11. ^ Takahashi K, Liu FC, Oishi T, Mori T, Higo N, Hayashi M, et al. (July 2008). "Expression of FOXP2 in the developing monkey forebrain: comparison with the expression of the genes FOXP1, PBX3, and MEIS2". The Journal of Comparative Neurology. 509 (2): 180–9. doi:10.1002/cne.21740. PMID 18461604. S2CID 5166430.
  12. ^ Larsen KB, Lutterodt MC, Laursen H, Graem N, Pakkenberg B, Møllgård K, et al. (July 2010). "Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain". Developmental Neuroscience. 32 (2): 149–62. doi:10.1159/000297602. PMID 20523026. S2CID 21973035.
  13. ^ Britanova O, de Juan Romero C, Cheung A, Kwan KY, Schwark M, Gyorgy A, et al. (February 2008). "Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex". Neuron. 57 (3): 378–92. doi:10.1016/j.neuron.2007.12.028. PMID 18255031. S2CID 9248058.
  14. ^ a b "Entrez Gene: KMT2A lysine (K)-specific methyltransferase 2A".
  15. ^ Zhang H, Gayen S, Xiong J, Zhou B, Shanmugam AK, Sun Y, et al. (2016). "MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency". Cell Stem Cell. 18 (4): 481–94. doi:10.1016/j.stem.2016.02.004. PMC 4826731. PMID 26996599.
  16. ^ Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M (November 2002). "Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties". Blood. 100 (10): 3710–8. doi:10.1182/blood-2002-04-1015. PMID 12393701.
  17. ^ Mohan M, Herz HM, Shilatifard A (April 2012). "SnapShot: Histone lysine methylase complexes". Cell. 149 (2): 498–498.e1. doi:10.1016/j.cell.2012.03.025. PMC 3711870. PMID 22500810.
  18. ^ a b Shulha HP, Cheung I, Whittle C, Wang J, Virgil D, Lin CL, et al. (March 2012). "Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons". Archives of General Psychiatry. 69 (3): 314–24. doi:10.1001/archgenpsychiatry.2011.151. PMID 22065254.
  19. ^ a b Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, et al. (October 2007). "Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters". The Journal of Neuroscience. 27 (42): 11254–62. doi:10.1523/JNEUROSCI.3272-07.2007. PMC 6673022. PMID 17942719.
  20. ^ Shen E, Shulha H, Weng Z, Akbarian S (September 2014). "Regulation of histone H3K4 methylation in brain development and disease". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369 (1652): 20130514. doi:10.1098/rstb.2013.0514. PMC 4142035. PMID 25135975.
  21. ^ Booth LN, Brunet A (2016). "The Aging Epigenome". Molecular Cell. 62 (5): 728–744. doi:10.1016/j.molcel.2016.05.013. PMC 4917370. PMID 27259204.
  22. ^ Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, et al. (June 2005). "Global and Hox-specific roles for the MLL1 methyltransferase". Proceedings of the National Academy of Sciences of the United States of America. 102 (24): 8603–8. Bibcode:2005PNAS..102.8603G. doi:10.1073/pnas.0503072102. PMC 1150839. PMID 15941828.
  23. ^ a b Andersson AK, Ma J, Wang J, Chen X, Gedman AL, Dang J, et al. (April 2015). "The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias". Nature Genetics. 47 (4): 330–7. doi:10.1038/ng.3230. PMC 4553269. PMID 25730765.
  24. ^ Mendelsohn BA, Pronold M, Long R, Smaoui N, Slavotinek AM (August 2014). "Advanced bone age in a girl with Wiedemann-Steiner syndrome and an exonic deletion in KMT2A (MLL)". American Journal of Medical Genetics. Part A. 164A (8): 2079–83. doi:10.1002/ajmg.a.36590. PMID 24818805. S2CID 20957397.
  25. ^ a b c d e Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, et al. (July 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Molecular and Cellular Biology. 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. PMC 480881. PMID 15199122.
  26. ^ Goto NK, Zor T, Martinez-Yamout M, Dyson HJ, Wright PE (November 2002). "Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain". The Journal of Biological Chemistry. 277 (45): 43168–74. doi:10.1074/jbc.M207660200. PMID 12205094.
  27. ^ Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ (April 2001). "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology. 21 (7): 2249–58. doi:10.1128/MCB.21.7.2249-2258.2001. PMC 86859. PMID 11259575.
  28. ^ a b Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ (July 2003). "MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8342–7. Bibcode:2003PNAS..100.8342X. doi:10.1073/pnas.1436338100. PMC 166231. PMID 12829790.
  29. ^ Fair K, Anderson M, Bulanova E, Mi H, Tropschug M, Diaz MO (May 2001). "Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells". Molecular and Cellular Biology. 21 (10): 3589–97. doi:10.1128/MCB.21.10.3589-3597.2001. PMC 100280. PMID 11313484.
  30. ^ Adler HT, Chinery R, Wu DY, Kussick SJ, Payne JM, Fornace AJ, et al. (October 1999). "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins". Molecular and Cellular Biology. 19 (10): 7050–60. doi:10.1128/mcb.19.10.7050. PMC 84700. PMID 10490642.

Further reading

Read other articles:

Alex Ross

Alex RossAlex Ross pada tahun 2003.NegaraAmerikaAreaPelukis dan IlustratorKarya terkenalJLA Liberty and JusticeJLA Secret OriginsKingdom ComeMarvelsPenghargaanWill Eisner Award (1997)National Cartoonists Society Comic Book Award (1998)http://www.alexrossart.com Nelson Alexander Alex Ross (lahir 22 Januari 1970)[1] adalah seorang pelukis komik, ilustrator dan penulis cerita, karyanya yang bergaya photorealisme selalu di kagumi orang. Ross terkenal karena kecintaannya terhadap penampila...

 

Thomas and Friends

Thomas & FriendsNama alternatif Thomas the Tank Engine & Friends (judul asli; seri 1–6) Thomas & Friends (seri 7–21) Thomas & Friends: Big World! Big Adventures! (seri 22–24)[1] GenreSerial televisi anak-anakPembuatRev. W. AwdryBerdasarkanThe Railway Seriesoleh Rev. W. Awdry Christopher Awdry PengembangBritt AllcroftSutradara David Mitton (Seri 1–7) Steve Asquith (Seri 8–12) Greg Tiernan (Seri 13–16) David Baas (Seri 17) Don Spencer (Seri 18) Dianna Basso ...

 

FC Monmouth

This article uses bare URLs, which are uninformative and vulnerable to link rot. Please consider converting them to full citations to ensure the article remains verifiable and maintains a consistent citation style. Several templates and tools are available to assist in formatting, such as reFill (documentation) and Citation bot (documentation). (September 2022) (Learn how and when to remove this template message) Soccer clubFC MonmouthFull nameFC MonmouthFounded2017; 7 years ago&...

U.S. Lecce

LecceNama lengkapUnione Sportiva Lecce SpAJulukanGiallorossi (Kuning-Merah), Salentini (Salentians); Lupi (Si Serigala)Berdiri15 Maret 1908; 116 tahun lalu (1908-03-15)StadionStadion Via del Mare,Lecce, Puglia, Italia(Kapasitas: 36,285[1])Presiden Savario Sticchi DamianiPelatih Roberto D'AversaLigaSerie A2022–2023Serie A, ke-16 dari 20Situs webSitus web resmi klub Kostum kandang Kostum tandang Kostum ketiga Musim ini Unione Sportiva Lecce adalah tim sepak bola Italia yang ...

 

Romery (Marne)

Pour les articles homonymes, voir Romery. Cet article est une ébauche concernant une commune de la Marne. Vous pouvez partager vos connaissances en l’améliorant (comment ?). Le bandeau {{ébauche}} peut être enlevé et l’article évalué comme étant au stade « Bon début » quand il comporte assez de renseignements encyclopédiques concernant la commune. Si vous avez un doute, l’atelier de lecture du projet Communes de France est à votre disposition pour vous aider...

 

Cagliari Calcio 1986-1987

Voce principale: Cagliari Calcio. Cagliari CalcioStagione 1986-1987 Sport calcio Squadra Cagliari Allenatore Gustavo Giagnoni Presidente Gigi Riva, poi Lucio Cordeddu Serie B20º (retrocesso in Serie C1) Coppa ItaliaSemifinale Maggiori presenzeCampionato: Marchi (35) Miglior marcatoreCampionato: Montesano, Piras (7) StadioSant'Elia 1985-1986 1987-1988 Si invita a seguire il modello di voce Questa voce raccoglie le informazioni riguardanti il Cagliari Calcio nelle competizioni ufficiali ...

Sportvereniging Roda Juliana Combinatie

Roda JCCalcio De Trots van het zuiden (Orgoglio del sud) Segni distintivi Uniformi di gara Casa Trasferta Colori sociali Giallo, nero Dati societari Città Kerkrade Nazione  Paesi Bassi Confederazione UEFA Federazione KNVB Campionato Eerste Divisie Fondazione 1962 Presidente Herman Huirne Allenatore Bas Sibum Stadio Parkstad Limburg Stadion(19.979 posti) Sito web www.rodajc.nl Palmarès Eredivisie 1 Coppe dei Paesi Bassi 2 Si invita a seguire il modello di voce Lo Sportvereniging Roda J...

 

Edward S. Lacey

American politician Edward Lacey7th Comptroller of the CurrencyIn officeMay 1, 1889 – June 30, 1892Preceded byWilliam L. TrenholmSucceeded byA. Barton HepburnMember of the U.S. House of Representativesfrom Michigan's 3rd districtIn officeMarch 4, 1881 – March 3, 1885Preceded byJonas H. McGowanSucceeded byJames O'Donnell Personal detailsBorn(1835-11-26)November 26, 1835Chili, New York, U.S.DiedOctober 2, 1916(1916-10-02) (aged 80)Evanston, Illinois, U.S.P...

 

Saprophagy

Feeding on dead plant or animal biomass by sessile organisms Fungi are the primary decomposers in most environments, illustrated here Mycena interrupta. Saprophages are organisms that obtain nutrients by consuming decomposing dead plant or animal biomass.[1] They are distinguished from detritivores in that saprophages are sessile consumers while detritivores are mobile.[citation needed] Typical saprophagic animals include sedentary polychaetes such as amphitrites (Amphitritina...

Image stabilization

Techniques used to reduce blurring of images This article is about the photography technique. For the optical phenomena, see Stabilized images. Comparison of simplified image stabilisation systems: unstabilisedlens-based optical stabilisationsensor-shift optical stabilisationdigital or electronic stabilisation Image stabilization (IS) is a family of techniques that reduce blurring associated with the motion of a camera or other imaging device during exposure. Generally, it compensates for pan...

 

Sophia Loren

Disambiguazione – Loren rimanda qui. Se stai cercando altri significati, vedi Loren (disambigua). Sophia Loren nel 1960 Oscar alla miglior attrice 1962 Oscar alla carriera 1991 Premio Imperiale 2010 Sophia Loren, pseudonimo di Sofia Costanza Brigida Villani Scicolone (Roma, 20 settembre 1934), è un'attrice italiana con cittadinanza francese[1][2]. Entra a far parte della settima arte molto giovane e s'impone agli inizi degli anni cinquanta, grazie ai suoi ruoli in ...

 

Johan Halvorsen

Norwegian composer, conductor and violinist (1864 - 1935) Not to be confused with John Halvorsen or Johan Magnus Halvorsen. Johan HalvorsenBackground informationBorn15 March 1864Drammen, NorwayDied4 December 1935 (age 71)Oslo, NorwayGenresClassicalOccupation(s)Conductor, pedagogue, violinistInstrument(s)ViolinMusical artist Johan Halvorsen (15 March 1864 – 4 December 1935) was a Norwegian composer, conductor and violinist. Life Born in Drammen, he was an accomplished violinist from a v...

Jalan Jaksa (seri televisi)

Jalan JaksaGenre Drama Komedi PembuatTripar Multivision PlusPengembang Kishur Ken Abimael Ditulis oleh Ery Setyawan Cuk FK SkenarioZulki ZakariaCeritaRenaldiSutradara Cuk FK Ery Setyawan Pengarah kreatifRaakhee PunjabiPemeran Nova Eliza Indra L Bruggman Rheina Maryana Cici Tegal Stefanie Hariadi Risdo Alaro Gracia Indri Five Vi Fanny Syam Opie Kumis Agus Kuncoro Gisela Cindy Shandy Sjariff Lagu pembukaJalan Jaksa, Didi AGPLagu penutupJalan Jaksa, Didi AGPPenata musikDidi AGPNegara asal...

 

Ski jumping at the 1994 Winter Olympics

Ski jumpingat the XVII Olympic Winter GamesVenueLysgårdsbakkenDates20–25 FebruaryNo. of events3Competitors68 from 19 nations← 19921998 → Ski jumping at the1994 Winter OlympicsNormal hillmenLarge hillmenTeammenvte Ski jumping at the 1994 Winter Olympics consisted of three events held from 20 February to 25 February, taking place at Lysgårdsbakken.[1][2] Medal summary Medal table [1] RankNationGoldSilverBronzeTotal1 Germany ...

 

Deep Creek (Washington)

River in Washington, United StatesDeep CreekDeep Creek CanyonLocation of the mouth of Deep Creek in WashingtonShow map of Washington (state)Deep Creek (Washington) (the United States)Show map of the United StatesLocationCountryUnited StatesStateWashingtonCountySpokanePhysical characteristicsSourceConfluence of North and South Forks • locationNear Espanola, Washington • coordinates47°37′14″N 117°45′33″W / 47.62056°N 117.75917°W&#...

The Masked Singer (American TV series) season 7

Season of television series The Masked Singer: The Good, The Bad, and The CuddlySeason 7Promotional poster for season seven, featuring Prince, Ram, and Space BunnyStarring Robin Thicke Jenny McCarthy Wahlberg Ken Jeong Nicole Scherzinger Hosted byNick CannonNo. of contestants15WinnerTeyana Taylor as FireflyRunner-upHayley Orrantia as Ringmaster No. of episodes12ReleaseOriginal networkFoxOriginal releaseMarch 9 (2022-03-09) –May 18, 2022 (2022-05-18)Season chronology← ...

 

Swallow the Sun (seri televisi)

Swallow the SunPoster promosi unutk Swallow the SunGenreLaga, Romansa, DramaBerdasarkanSwallow the Sunoleh Kang Chul-hwaDitulis olehChoi Wan-kyuSutradaraYoo Chul-yongPemeranJi Sung Sung Yu-ri Lee Wan Jun Kwang-ryulNegara asalKorea SelatanBahasa asliKoreaJmlh. episode25ProduksiLokasi produksiPulau Jeju Las Vegas JohannesburgDurasi60 menit Rabu dan Kamis pukul 21:55 (WSK)Rilis asliFormat audioStereoRilis9 Juli (2009-07-09) –1 Oktober 2009 (2009-10-1) Swallow the Sun (Hangul...

 

Terramare

Disambiguazione – Se stai cercando il mondo immaginario creato dalla scrittrice Ursula K. Le Guin, vedi Earthsea (mondo immaginario). Disambiguazione – Se stai cercando il film d'animazione giapponese creato dallo Studio Ghibli, vedi I racconti di Terramare. TerramareTerramara di Montale (Modena), le due abitazioni ricostruiteRegioneItalia settentrionale PeriodoEtà del bronzo media e recente Dateca. 1650-1150 a.C. Sito tipoTerramara di Montale Altri sitiTerramara di Pilastri Età del br...

2009

This article is about the year 2009. For the Glee episode, see 2009 (Glee). 2009 January February March April May June July August September October November December Clockwise from top-left: Air France Flight 447 crashes in the Atlantic Ocean leaving no survivors; Barack Obama becomes the first African American to become President of the United States; protests erupt over the 2009 Iranian presidential election; US Airways Flight 1549 crash-lands in the Hudson River with no fatalities, with ...

 

Jack Heinz

American business executive (1908–1987) Jack HeinzBornHenry John Heinz II(1908-07-10)July 10, 1908Pittsburgh, Pennsylvania, U.S.DiedFebruary 23, 1987(1987-02-23) (aged 78)Hobe Sound, Florida, U.S.Occupation(s)Business executive, former CEO of the H. J. Heinz CompanyChildrenJohn HeinzRelativesHenry J. Heinz (grandfather) Donald Trump (fourth cousin) Henry John Heinz II (July 10, 1908 – February 23, 1987) was an American business executive and CEO of the H. J. Heinz Company based i...