CXCL9

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Hemokin (C-X-C motiv) ligand 9
Identifikatori
SimboliCXCL9; CMK; Humig; MIG; SCYB9; crg-10
Vanjski IDOMIM601704 MGI1352449 HomoloGene1813 GeneCards: CXCL9 Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez428317329
EnsemblENSG00000138755ENSMUSG00000029417
UniProtQ07325n/a
RefSeq (mRNA)NM_002416NM_008599
RefSeq (protein)NP_002407NP_032625
Lokacija (UCSC)Chr 4:
77.14 - 77.15 Mb
Chr 5:
93.4 - 93.4 Mb
PubMed pretraga[1][2]

CXCL9, hemokine (C-X-C motif) ligand 9, je mali citokin iz CXC hemokin familije. On je takođe poznat kao monokin indukovan gama interferonom (MIG). CXCL9 je T-ćelijski hemoatraktant. On je blisko srodan sa dva druga CXC hemokina: CXCL10 i CXCL11, čiji geni su locirani u blizini CXCL9 gena na ljudskom hromozomu 4.[1][2] CXCL9, CXCL10 i CXCL11 invršavaju svoje hemotaksne funkcije putem interakcija sa hemokin receptorom CXCR3.[3][4]

Interakcije

Za CXCL9 je bilo pokazano da ostvaruje interakcije sa CXCR3.[5][6]

Reference

  1. Lee HH, Farber JM (1996). „Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster"”. Cytogenet. Cell Genet. 74 (4): 255–8. DOI:10.1159/000134428. PMID 8976378. 
  2. O'Donovan N, Galvin M, Morgan JG (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet. 84 (1-2): 39–42. DOI:10.1159/000015209. PMID 10343098. 
  3. Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999). „Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)”. J. Invest. Dermatol. 112 (5): 716–22. DOI:10.1046/j.1523-1747.1999.00581.x. PMID 10233762. 
  4. Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  5. Lasagni, Laura; Francalanci Michela, Annunziato Francesco, Lazzeri Elena, Giannini Stefano, Cosmi Lorenzo, Sagrinati Costanza, Mazzinghi Benedetta, Orlando Claudio, Maggi Enrico, Marra Fabio, Romagnani Sergio, Serio Mario, Romagnani Paola (June 2003). „An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4”. J. Exp. Med. (United States) 197 (11): 1537–49. DOI:10.1084/jem.20021897. ISSN 0022-1007. PMC 2193908. PMID 12782716. 
  6. Weng, Y; Siciliano S J, Waldburger K E, Sirotina-Meisher A, Staruch M J, Daugherty B L, Gould S L, Springer M S, DeMartino J A (July 1998). „Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors”. J. Biol. Chem. (UNITED STATES) 273 (29): 18288–91. DOI:10.1074/jbc.273.29.18288. ISSN 0021-9258. PMID 9660793. 

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