CCL25

Hemokin (C-C motiv) ligand 25
Identifikatori
Simbol CCL25
Alt. simboli SCYA25, TECK, Ckb15
Entrez 6370
HUGO 10624
OMIM 602565
RefSeq NM_005624
UniProt O15444
Drugi podaci
Lokus Hromozom 19 p13.2

CCL25, hemokin (C-C motiv) ligand 25, je mali citokin iz CC hemokin familije koji je takođe poznat kao TECK (timusom izražen hemokin). Za CCL25 se veruje da učestvuje u razvoju T-ćelija.[1] On je hemotaksan za timocite, makrofage, i dendritske ćelije. CCL25 destvuje vezivanjem za hemokinski receptor CCR9.[2][3] Ljudski CCL25 nastaje kao protein prekurzor koji sadrži 151 aminokiselina. CCL25 gen (scya25) je lociran na ljudskom hromozomu 19.[4][5]

Reference

  1. ↑ Vacari et al. (1997). „TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development”. Immunity 7: 291-301. 
  2. ↑ Zaballos et al. (1999). „Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK”. J. Immunol. 162: 5671-5675. 
  3. ↑ Gosling et al. (2000). „Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK”. J Immunol 164: 2851-6. 
  4. ↑ Nomiyama et al. (1998). „The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2”. Genomics 51: 311-312. 
  5. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

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