Kardiotrofin 1

Kardiotrofin 1
Identifikatori
Simbol CTF1
Entrez 1489
HUGO 2499
OMIM 600435
RefSeq NM_001330
UniProt Q16619
Drugi podaci
Lokus Hromozom 16 p11.2-16p11.1

Kardiotrofin-1 (CT-1) je citokin. On je srčani hipertrofni faktor sa 21.5 kDa, i član IL-6 citokinske familije. CT-1 je povezan sa patofiziologijom srčanih bolesti[1], kao što su hipertenzija, miokardijalna infarkcija, valvularna srčana mana, and kongestivna srčana slabost. Ovaj protein deluje putem interakcije sa glikoproteinom 130 (gp130)/leukemijskim inhibitornim faktorom receptor beta (LIFR) heterodimera. Dodatno, CT-1 aktivira fosfatidilinozitol 3-kinazu (PI-3 kinaza) u srčanim mišićima i pojačava DNK-vezivanje transkripcionog faktora NF-κB. CT-1 je visoko izražen u srcu, skeletalnim mišićima[2], prostati i jajnicima, i u manjoj meri u plućima, bubrezima, pankreasu, timusu, testisima i tankim crevima.[3][4][5]

Reference

  1. ↑ Ronald W. Oppenheim, Stefan Wiese, David Prevette, Mark Armanini, Siwei Wang, Lucien J. Houenou, Bettina Holtmann, Rudolf Götz, Diane Pennica, and Michael Sendtner (2001). „Cardiotrophin-1, a Muscle-Derived Cytokine, Is Required for the Survival of Subpopulations of Developing Motoneurons”. The Journal of Neuroscience 2 (4): 283-29. 
  2. ↑ Tian Li, Larisa M. Wiggins, and Christopher S. von Bartheld (2010). „Insulin-like Growth Factor-1 and Cardiotrophin 1 Increase Strength and Mass of Extraocular Muscle in Juvenile Chicken”. Investigative Ophthalmology and Visual Science 51: 2479-2486. DOI:10.1167/iovs.09-4414. 
  3. ↑ „Cardiotrophin-1 (CT-1)”. 
  4. ↑ Freed DH, Moon MC, Borowiec AM, Jones SC, Zahradka P, Dixon IM. (2003). „Cardiotrophin-1: expression in experimental myocardial infarction and potential role in post-MI wound healing”. Mol Cell Biochem 254 (1-2): 247-56. PMID 14674704. 
  5. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

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