CXCL13

Hemokin (C-X-C motiv) ligand 13 (B-ćelijski hemoatraktant)
Identifikatori
Simbol	CXCL13
Alt. simboli	SCYB13, BLC, BCA-1, BLR1L, ANGIE, ANGIE2
Entrez	10563
HUGO	10639
OMIM	605149
RefSeq	NM_006419
UniProt	O43927
Drugi podaci
Lokus	Hromozom 4 q21

CXCL13, hemokin (C-X-C motiv) ligand 13, je mali citokin iz CXC hemokin familije koji je takođe poznat kao B limfocit hemoatraktant (BLC). Ovaj hemokin je selektivno hemotaksan za B ćelije iz B-1 i B-2 grupe. On dejstvuje putem interakcije sa hemokin receptorom CXCR5.^[1]^[2] CXCL13 i njegov receptor CXCR5 kontrolišu organizaciju B ćelija unutar folikula limfoidnih tkiva.^[3] Ovaj hemokin izlučuju dendritske ćelije,^[4] i on je visoko izražen u jetri, slezini, limfnim čvorovima, i stomaku ljudi.^[5] Gen za CXCL13 je lociran na ljudskom hromozomu 4 u klasteru sa drugim CXC hemokinima.^[6]^[7]

U T-limfocitima, CXCL13 ekspresija se smatra odrazom germinalnog centra porekla T-ćelija. Otuda, CXCL13 izražavanje u T-ćelijskim limfomima, kao što su angioimunoblastni T-ćelijski limfomi, se smatra da ukazuje na germinalno poreklo neoplastičnih T-ćelija.^[8]

Reference

↑ Ansel, K. M.; Harris, R. B. S.; Cyster, J. G. (2002). „CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity.”. Immunity 16: 67-76. PMID 11825566.
↑ Legler, D. F.; Loetscher, M.; Roos, R. S.; Clark-Lewis, I.; Baggiolini, M.; Moser, B. (1998). „B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.”. J. Exp. Med. 187: 655-660. PMID 9463416.
↑ Ansel, K. M.; Ngo, V. N.; Hyman, P. L.; Luther, S. A.; Forster, R.; Sedgwick, J. D.; Browning, J. L.; Lipp, M.; Cyster, J. G.. „A chemokine-driven positive feedback loop organizes lymphoid follicles”. Nature 2000: 309-314. PMID 10917533.
↑ Vissers JL, Hartgers FC, Lindhout E, Figdor CG, Adema GJ. (2001). „BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo”. Eur J Immunol 31 (5): 1544-9. PMID 11465112.
↑ Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B. (1998). „B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.”. J. Exp. Med. 187: 655-660. PMID 9463416.
↑ Gunn, M. D.; Ngo, V. N.; Ansel, K. M.; Ekland, E. H.; Cyster, J. G.; Williams, L. T. A (1998). „B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1”. Nature 391: 799-803. PMID 9486651.
↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
↑ de Leval et al. (2007). „The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T cells (TFH)”. Blood.

[1] Ansel, K. M.; Harris, R. B. S.; Cyster, J. G. (2002). „CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity.”. Immunity 16: 67-76. PMID 11825566.

[2] Legler, D. F.; Loetscher, M.; Roos, R. S.; Clark-Lewis, I.; Baggiolini, M.; Moser, B. (1998). „B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.”. J. Exp. Med. 187: 655-660. PMID 9463416.

[3] Ansel, K. M.; Ngo, V. N.; Hyman, P. L.; Luther, S. A.; Forster, R.; Sedgwick, J. D.; Browning, J. L.; Lipp, M.; Cyster, J. G.. „A chemokine-driven positive feedback loop organizes lymphoid follicles”. Nature 2000: 309-314. PMID 10917533.

[4] Vissers JL, Hartgers FC, Lindhout E, Figdor CG, Adema GJ. (2001). „BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo”. Eur J Immunol 31 (5): 1544-9. PMID 11465112.

[5] Legler D.F., Loetscher M., Stuber Roos R., Clark-Lewis I., Baggiolini M., Moser B. (1998). „B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.”. J. Exp. Med. 187: 655-660. PMID 9463416.

[6] Gunn, M. D.; Ngo, V. N.; Ansel, K. M.; Ekland, E. H.; Cyster, J. G.; Williams, L. T. A (1998). „B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1”. Nature 391: 799-803. PMID 9486651.

[7] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[8] Leval et al. (2007). „The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T cells (TFH)”. Blood.

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CXCL13

Reference

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