CCL5

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Hemokin (C-C motiv) ligand 5

PDB prikaz baziran na 1pmi.
Dostupne strukture
1b3a, 1eqt, 1hrj, 1rtn, 1rto, 1u4l, 1u4m, 1u4p, 1u4r
Identifikatori
SimboliCCL5; D17S136E; MGC17164; RANTES; SCYA5; SISd; TCP228
Vanjski IDOMIM: 187011 MGI: 98262 HomoloGene: 2244 GeneCards: CCL5 Gene
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez635220304
EnsemblENSG00000161570ENSMUSG00000035042
UniProtP13501Q5XZF2
RefSeq (mRNA)NM_002985NM_013653
RefSeq (protein)NP_002976NP_038681
Lokacija (UCSC)Chr 17:
31.22 - 31.23 Mb		Chr 11:
83.34 - 83.35 Mb
PubMed pretraga[1][2]

CCL5, hemokin (C-C motiv) ligand 5, takođe poznat kao RANTES (engl. Regulated upon Activation, Normal T-cell Expressed, and Secreted) je protein koji je kod ljudi kodiran CCL5 genom.[1][2]

Funkcija

CCL5 je 8 kDa protein koji je klasifikovan kao hemotaksni citokin ili hemokin. CCL5 je hemoatraktant T ćelija, eozinofila, i bazofila. On učestvuje u regrutovanju leukocita na mesta zapaljenja. Uz pomoć određenih citokina (npr., IL-2 i IFN-γ) koji se oslobađaju iz T ćelija, CCL5 takođe stimuliše proliferaciju i aktivaciju pojedinih tipova (NK) ćelija da formiraju CHAK (CC-hemokin-aktivirane ubice) ćelije.[3] CCL5 je takođe HIV-supresivni faktor koji izlučuju CD8+ T ćelije. Gen ovog hemokina je lociran na hromozomu 17 kod ljudi.[4]

RANTES je prvobitno bio identifikovan u toku potrage za "kasno" izraženim genima (3–5 dana) nakon T ćelijske aktivacije. Naknadno je bilo utvrđeno da je on CC hemokin i da je izražen u više od 100 ljudskih bolesti. RANTES izražavanje je regulisano u T limfocitima Krupel sličnim faktorom 13 (KLF13).[5][6][7][8]

Interakcije

Za CCL5 se zna da formira interakcije sa CCR3,[9][10] CCR5[10][11][12] and CCR1.[10][12]

CCL5 takođe aktivira G-protein spregnuti receptor GPR75.[13]

Povezano

Reference

  1. ↑ Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C (March 1990). „Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12”. Genomics 6 (3): 548–53. DOI:10.1016/0888-7543(90)90485-D. PMID 1691736. 
  2. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 
  3. ↑ Maghazachi et al. (1996). „CC chemokines induce the generation of killer cells from CD56+ cells”. Eur J Immunol 26: 315-9. PMID 8617297. 
  4. ↑ Donlon et al. (1990). „Localization of a human T-cell-specific gene, CCL5 (D17S136E), to chromosome 17q11.2-q12.”. Genomics 5: 548-553. PMID 1691736. 
  5. ↑ Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM, Krensky AM (August 1988). „A human T cell-specific molecule is a member of a new gene family”. J. Immunol. 141 (3): 1018–25. PMID 2456327. 
  6. ↑ Krensky, Alan M. (1995). Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). R G Landes Co. ISBN 1-57059-253-5. 
  7. ↑ Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (January 1999). „RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes”. Immunity 10 (1): 93–103. DOI:10.1016/S1074-7613(00)80010-2. PMID 10023774. 
  8. ↑ Song A, Nikolcheva T, Krensky AM (October 2000). „Transcriptional regulation of RANTES expression in T lymphocytes”. Immunol. Rev. 177: 236–45. DOI:10.1034/j.1600-065X.2000.17610.x. PMID 11138780. 
  9. ↑ Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (May 1996). „Cloning, expression, and characterization of the human eosinophil eotaxin receptor”. J. Exp. Med. 183 (5): 2349–54. PMC 2192548. PMID 8642344. 
  10. ↑ 10,0 10,1 10,2 Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). „Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils”. Eur. J. Immunol. 31 (7): 2170–8. DOI:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. PMID 11449371. 
  11. ↑ Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L (October 2003). „Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages”. Biochim. Biophys. Acta 1617 (1-2): 80–8. PMID 14637022. 
  12. ↑ 12,0 12,1 Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (April 2001). „The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity”. J. Biol. Chem. 276 (14): 10620–6. DOI:10.1074/jbc.M010867200. PMID 11116158. 
  13. ↑ Ignatov A, Robert J, Gregory-Evans C, Schaller HC (November 2006). „RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75”. Br. J. Pharmacol. 149 (5): 490–7. DOI:10.1038/sj.bjp.0706909. PMC 2014681. PMID 17001303. 

Literatura

  • Muthumani K, Desai BM, Hwang DS, et al. (2004). „HIV-1 Vpr and anti-inflammatory activity.”. DNA Cell Biol. 23 (4): 239–47. DOI:10.1089/104454904773819824. PMID 15142381. 
  • Zhao RY, Elder RT (2005). „Viral infections and cell cycle G2/M regulation.”. Cell Res. 15 (3): 143–9. DOI:10.1038/sj.cr.7290279. PMID 15780175. 
  • Zhao RY, Bukrinsky M, Elder RT (2005). „HIV-1 viral protein R (Vpr) & host cellular responses.”. Indian J. Med. Res. 121 (4): 270–86. PMID 15817944. 
  • Li L, Li HS, Pauza CD, et al. (2006). „Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.”. Cell Res. 15 (11-12): 923–34. DOI:10.1038/sj.cr.7290370. PMID 16354571. 
  • Krensky, Alan M. (1995). Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). R G Landes Co. 

Vanjske veze