CCL13

Hemokin (C-C motiv) ligand 13
Identifikatori
Simbol CCL13
Alt. simboli SCYA13, MCP-4, NCC-1, SCYL1, CKb10
Entrez 6357
HUGO 10611
OMIM 601391
RefSeq NM_005408
UniProt Q99616
Drugi podaci
Lokus Hromozom 17 q11.2

CCL13, hemokin (C-C motiv) ligand 13, je mali citokin iz CC hemokin familije. Njegov gen se nalazi na ljudskom hromozomu 17 unutar velikog klastera CC hemokina.[1][2] CCL13 indukuje hemotaksu monocita, eozinofila, T limfocita, i bazofila putem vezivanja za G-protein spregnute hemokin receptore kao što su CCR2, CCR3 i CCR5.[3] Aktivnost ovog hemokina je bila implicirana u alergijske reakcije kao što je astma.[4] CCL13 može biti indukovan inflamatornim citokinima interleukin 1 i TNF-α.[5]

Reference

  1. ↑ Garcia-Zepeda EA, et al. (1996). „Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3”. J Immunol 157: 5613–5626. 
  2. ↑ Naruse et al. (1996). „A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2”. Genomics 34 (2): 236-40. 
  3. ↑ Blanpain et al. (1999). „CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist”. Blood 94: 1899-905. 
  4. ↑ Lamkhioued et al. (2000). „Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines”. Am J Respir Crit Care Med 162: 723-32. 
  5. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

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