CCL15

Hemokin (C-C motiv) ligand 15
Identifikatori
Simbol CCL15
Alt. simboli SCYA15, HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B
Entrez 6359
HUGO 10613
OMIM 601393
PDB 2HCC
RefSeq NM_032965
UniProt Q16663
Drugi podaci
Lokus Hromozom 17 q11.2

CCL15, hemokin (C-C motif) ligand 15, je mali citokin iz CC hemokin familiji koji je poznat kao leukotaktin-1, MIP5 i HCC-2. CCL15 je izražen u jetri, tankim crevima, kolonu, i u pojedinim tipovima leukocita i makrofaga u plućima.[1] CCL15 je hemotaksan za neutrofile, monocite, i limfocite. On dejstvuje putem vezivanja za hemokinske receptore na ćelijskoj površini poput CCR1 i CCR3.[2][3] Ljudski CCL15 gen sadrži četiri eksona i lociran je na hromozomu 17 zajedno sa ja još jednim CC hemokinom poznatim kao CCL14.[4][5]

Reference

  1. ↑ Pardigol et al. (1998). „HCC-2, a human chemokine: gene structure, expression pattern, and biological activity”. Proc. Nat. Acad. Sci. 95: 6308-6313. 
  2. ↑ Youn et al. (1997). „Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3.”. J. Immun 159: 5201-5205. 
  3. ↑ Coulin et al. (1997). „Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines”. Europ. J. Biochem 248: 507-515. 
  4. ↑ Naruse et al. (1996). „A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2”. Genomics 34: 236-240. 
  5. ↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

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