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SB-612,111
SB-612,111
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| (IUPAC) ime
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| (5S,7S)-7[4-(2,6-dihlorofenil)piperidin-1-il]metil1-metil-6,7,8,9-tetrahidro-5H-benzo[7]anulen-5-ol
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| Klinički podaci
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| Identifikatori
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| ATC kod
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?
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| PubChem[1][2]
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10047612
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| Hemijski podaci
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| Formula
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C24H29Cl2NO
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| Mol. masa
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418,398 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
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InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3/t17-,23-/m0/s1  Y
Key: OHRDCQFCAWLDBP-SBUREZEXSA-N Y |
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| Sinonimi
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SB-612,111
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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SB-612,111 je ligand opioidnog receptora. On je potentan i selektivan antagonist za nociceptinskog receptora (ORL-1). Ovaj ligand je nekoliko puta potentniji od starijeg leka J-113,397.[3] On ne proizvodi analgetičke efekte, nego sprečava razvoj hiperalgezije.[4] Pokazano je da ima antidepresivno dejstvo u studijama na životinjama.[5]
Povezano
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Spagnolo, B; Carrà, G; Fantin, M; Fischetti, C; Hebbes, C; McDonald, J; Barnes, TA; Rizzi, A i dr.. (2007). „Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-ylmethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol: in vitro studies”. The Journal of pharmacology and experimental therapeutics 321 (3): 961–7. DOI:10.1124/jpet.106.116764. PMID 17329552.
- ↑ Zaratin, PF; Petrone, G; Sbacchi, M; Garnier, M; Fossati, C; Petrillo, P; Ronzoni, S; Giardina, GA i dr.. (2004). „Modification of nociception and morphine tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-ylmethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)”. The Journal of pharmacology and experimental therapeutics 308 (2): 454–61. DOI:10.1124/jpet.103.055848. PMID 14593080.
- ↑ Rizzi, A; Gavioli, EC; Marzola, G; Spagnolo, B; Zucchini, S; Ciccocioppo, R; Trapella, C; Regoli, D i dr.. (2007). „Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-ylmethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol: in vivo studies”. The Journal of pharmacology and experimental therapeutics 321 (3): 968–74. DOI:10.1124/jpet.106.116780. PMID 17329551.
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