Nalorfin

Nalorfin
Klinički podaci
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 62-67-9
ATC kod V03AB02
PubChem[1][2] 5284595
ChemSpider[3] 4447643
UNII U59WB2WRY2 DaY
ChEMBL[4] CHEMBL415284 DaY
Hemijski podaci
Formula C19H21NO3 
Mol. masa 311,375
SMILES eMolekuli & PubHem
Sinonimi (−)−(5R,6S)-9α-allyl- 4,5-epoxymorphin- 7-en- 3,6-diol
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Nalorfin je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 311,375 Da.

Osobine

Osobina Vrednost
Broj akceptora vodonika 4
Broj donora vodonika 2
Broj rotacionih veza 2
Particioni koeficijent[5] (ALogP) 2,0
Rastvorljivost[6] (logS, log(mol/L)) -2,8
Polarna površina[7] (PSA, Å2) 52,9

Reference

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o. 
  6. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573. 
  7. Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286. 

Literatura

Spoljašnje veze

Read other articles:

Clifton Collins Jr. Información personalNombre de nacimiento Clifton Craig Collins, Jr.Nacimiento 16 de junio de 1970 (53 años) Los Ángeles, California, Estados UnidosNacionalidad EstadounidenseLengua materna Inglés FamiliaFamiliares Pedro González González (abuelo)EducaciónEducado en Estudio de actuación Stella Adler Información profesionalOcupación ActorAños activo 1990-presenteSitio web CliftonCollingsJr.comPremios artísticosPremios SAG Mejor reparto2000 Traffic[edita...

Маяк у Ріміні Сучасний вигляд маяка Розташування Віа Дестра дель Порто, Ріміні, Емілія-Романья, ІталіяКоординати 44°04′27″ пн. ш. 12°34′26″ сх. д. / 44.074056° пн. ш. 12.573944° сх. д. / 44.074056; 12.573944Координати: 44°04′27″ пн. ш. 12°34′26″ сх. д. / þ...

Este artículo o sección necesita referencias que aparezcan en una publicación acreditada.Este aviso fue puesto el 30 de diciembre de 2019. Primera División 2017-18 XXVI Primera DivisiónDatos generalesSede Macedonia del NorteAsociación UEFAFecha 12 de agosto de 2017 20 de mayo de 2018Edición 26.ªPalmarésPrimero ShkëndijaSegundo VardarTercero RabotničkiDatos estadísticosParticipantes 10 equiposPartidos 180Goles 461 (2.56 goles por partido)Goleador Ferhan Hasani (22) Besart Ibraimi (...

Wappen von Hostinné Diese Liste von Bürgermeistern der Stadt Hostinné, deutsch Arnau, teilweise aus dem historischen Stadtbuch übernommen zeigt die Schultheiße und Bürgermeister von 1396 bis 1945. Die gewählten Bürgermeister wurden hauptsächlich für ein bis zwei Jahre vom Bürgerrat gewählt. Es gab bis zu zehn Schöffen im Rat. Ein Richter gehörte zum Stadtvorstand. Obwohl mehrere Adelsfamilien im Ort wohnten, stellte nur die Bürgerschaft die Bürgermeister. Inhaltsverzeichnis 1 ...

South Korean pop singer-songwriter In this Korean name, the family name is Go. This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libelous.Find sources: Younha – news · newspapers · books · scholar · JSTOR (July 2018) (L...

Gymnasium an der Stadtmauer Schulform Gymnasium Schulnummer 50600[1] Gründung 1807 (als Collège de Creuznach), 1819 (als Königlich-preußisches Gymnasium und Realgymnasium) Adresse Hospitalgasse 6 55543 Bad Kreuznach Land Rheinland-Pfalz Staat Deutschland Koordinaten 49° 50′ 32″ N, 7° 51′ 35″ O49.8422222222227.8597222222222Koordinaten: 49° 50′ 32″ N, 7° 51′ 35″ O Schüler 701[2] Lehrkräfte ca. ...

Diomede FalconioPrefek Kongregasi RelijiusGerejaGereja KatolikPenunjukan26 Februari 1916Masa jabatan berakhir8 Februari 1917PendahuluDomenico SerafiniPenerusGiulio TontiJabatan lainKardinal-Uskup Velletri (1914–17)ImamatTahbisan imam4 Januari 1866oleh Yohanes TimonTahbisan uskup17 Juli 1892oleh Raffaele Monaco La VallettaPelantikan kardinal27 November 1911oleh Paus Pius XPeringkatKardinal-Imam (1911–14)Kardinal-Uskup (1914–17)Informasi pribadiNama lahirAngelo Raffaele Gennaro ...

Benjamin Thorpe Nascimento Benjamin Thorpe1789 Morte 19 de julho de 1870 (81 anos) Nacionalidade britânico Cidadania inglês Ocupação Filólogo e historiador Benjamin Thorpe (1789 — 19 de julho de 1870) foi um estudioso inglês da literatura anglo-saxônica. Biografia Ancient laws and institutes of England, 1840 Na década de 1820, ele trabalhou no início de sua carreira como um banqueiro na casa da família Rothschild, em Paris. Lá ele conheceu Thomas Hodgkin, que o tratou d...

KolonelMuammar Khadafiمعمر محمد أبو منيار القذافيMuammar Khadafi saat tengah menghadiri pertemuan puncak Uni Afrika ke-12 di Addis Ababa pada tanggal 2 Februari 2009Pemimpin dan Penuntun Revolusi LibyaMasa jabatan1 September 1969 – 20 Oktober 2011[a]Presiden Lihat daftar Abdul Ati al-Obeidi Muhammad az-Zaruq Rajab Mifta al-Usta Umar Abdul Razzaq as-Sawsa Muhammad al-Zanati Miftah Muhammed K'eba Imbarek Shamekh Mohamed Abu al-Qasim al-Zwai Perdana Ment...

Horace ButterworthHorace ButterworthBiographical detailsBorn(1868-12-03)December 3, 1868DiedDecember 8, 1939(1939-12-08) (aged 71)Alma materUniversity of ChicagoCoaching career (HC unless noted)Football1907TempleBasketball1895–1897ChicagoBaseball1903Northwestern Administrative career (AD unless noted)1903–1904Northwestern Head coaching recordOverall4–0–2 (football)10–4 (basketball)17 games (baseball) Horace C. Butterworth (December 3, 1868 – December 8, 1939)[1] ...

Tempestade subtropical Andrea A tempestade subtropical Andrea pouco antes de ser classificado como tempestade subtropical História meteorológica Formação 9 de maio de 2007 Dissipação 11 de maio de 2007 Tempestade tropical 1-minuto sustentado (SSHWS/NWS) Ventos mais fortes 60 mph (95 km/h) Pressão mais baixa 1001 mbar (hPa); 29.56 inHg Efeitos gerais Danos mínimo Áreas afetadas Estados Unidos (Virginia, Carolina do Norte, Carolina do Sul, Geórgia e Flórida) e Bahamas ...

Country house near Ruabon, Wales Pen-y-Lan Hall1840-1860General informationArchitectural styleRegency gothicLocationRuabon, Wrexham County BoroughCountryWalesCoordinates52°57′46″N 3°00′01″W / 52.962822°N 3.000351°W / 52.962822; -3.000351Inaugurated1690Websitehttp://www.pen-y-lan.co.uk Pen-y-Lan Hall is a Grade II-listed Tudor-Gothic Revival country house located near the village of Ruabon in Wrexham County Borough, Wales. The building may have been built in...

This article relies largely or entirely on a single source. Relevant discussion may be found on the talk page. Please help improve this article by introducing citations to additional sources.Find sources: International Order of Characters – news · newspapers · books · scholar · JSTOR (November 2009) International Order of CharactersLogo, International Order of CharactersAn internationally recognized organizationAbbreviationIOCFormation1942PurposeAviati...

Some of this article's listed sources may not be reliable. Please help this article by looking for better, more reliable sources. Unreliable citations may be challenged or deleted. (October 2023) (Learn how and when to remove this template message) 2022 single by Lu KalaPretty Girl EraSingle by Lu KalaReleasedDecember 2, 2022Length2:35LabelAmigoSongwriter(s)Lusamba Vanessa KalalaLukasz GottwaldRocco ValdesMadison LoveProducer(s)Dr. LukeLu Kala singles chronology Pretty Girl Era (2022) Lottery...

U.S. brand of hot sauce Cholula Hot SauceProduct typeHot sauceOwnerMcCormick & CompanyCountryMexicoWebsiteCholula.com[1] Cholula Hot Sauce is a brand of chili-based hot sauce, based in Stamford, Connecticut, manufactured in Chapala, Jalisco, Mexico by SANE, and licensed by McCormick. According to its manufacturers, Cholula hot sauce rates 1,000–2,000 on the Scoville scale[2] though other sources measure it as being over three times as hot, at 3,600 Scoville units.[3&...

2020 drama miniseries Defending JacobGenreCrime dramaCreated byMark BombackBased onDefending Jacobby William LandayScreenplay byMark BombackDirected byMorten TyldumStarring Chris Evans Michelle Dockery Jaeden Martell Cherry Jones Pablo Schreiber Betty Gabriel Sakina Jaffrey J.K. Simmons Theme music composerOlafur ArnaldsComposerAtli ÖrvarssonCountry of originUnited StatesOriginal languageEnglishNo. of episodes8ProductionExecutive producers Mark Bomback Chris Evans Morten Tyldum Rosalie Swedl...

2011 novel by Una McCormack This article is about the Doctor Who novel. For the Inspector Morse novel, see The Way Through the Woods. The Way Through the Woods AuthorUna McCormackSeriesDoctor Who book:New Series AdventuresRelease number44SubjectFeaturing:Eleventh DoctorAmy PondRory WilliamsSet inPeriod betweenDay of the Moon and The God ComplexPublisherBBC BooksPublication date28 April 2011Pages241ISBN978-1-849-90237-3Preceded byDead of Winter Followed byHunter's Moon ...

Leader of His Majesty's Most Loyal OppositionIncumbentMoses Barrowsince February 1, 2022The OppositionNational Assembly of BelizeStyleThe HonourableResidenceBelize City, BelizeAppointerFroyla TzalamTerm lengthWhile leader of the largest political party in the House of Representatives that is not in governmentPrecursorMoses BarrowInaugural holderTheodore ArandaFormationSeptember 21, 1981DeputyHugo PattWebsitehttps://www.udp.org.bz/ Politics of Belize Constitution Human rights LGBT rights ...

Canadian daily newspaper For the Canadian Supreme Court case, see Vancouver Sun (Re). Vancouver SunSeriously WestcoastTypeDaily newspaperFormatBroadsheetOwner(s)Postmedia Network Inc.Editor-in-chiefHarold MunroFounded12 February 1912; 111 years ago (1912-02-12)Headquarters400-2985 Virtual Way, Vancouver, B.C., V5M 4X7ISSN0832-1299Websitevancouversun.com The Vancouver Sun, also known as the Sun, is a daily broadsheet newspaper based in Vancouver, British Columbia, Canada. The...

Ante VrbanBorn(1908-01-15)15 January 1908Pejakuša near Gospić, Kingdom of Croatia-Slavonia, Austria-HungaryDied31 August 1948(1948-08-31) (aged 40)Zagreb, PR Croatia, FPR Yugoslavia Cause of deathExecution by hanging Allegiance Independent State of Croatia Nazi GermanyService/branchUstaše MilitiaCroatian Armed ForcesYears of service1941–45Commands heldDeputy commander of Stara Gradiška concentration camp Ante Vrban (15 January 1908 – 31 August 1948) was a Croa...