Receptor insulinu sličnog faktora rasta 1

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Receptor insulinu sličnog faktora rasta 1‎‎

Prva tri domena receptora insulinu sličnog faktora rasta 1‎‎. PDB prikaz baziran na 1igr.
Dostupne strukture
1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU
Identifikatori
SimboliIGF1R; CD221; IGFIR; IGFR; JTK13
Vanjski IDOMIM: 147370 MGI: 96433 HomoloGene: 30997 GeneCards: IGF1R Gene
EC broj2.7.10.1
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez348016001
EnsemblENSG00000140443ENSMUSG00000005533
UniProtP08069Q60751
RefSeq (mRNA)NM_000875.3NM_010513.2
RefSeq (protein)NP_000866.1NP_034643.2
Lokacija (UCSC)Chr 15:
99.19 - 99.51 Mb		Chr 7:
67.95 - 68.23 Mb
PubMed pretraga[1][2]

Receptor insulinu sličnog faktora rasta 1 je protein koji je prisutan na površini ljudskih ćelija. On je transmembranski receptor koji se aktivira IGF-1 hormonom (insulinu sličan faktor rasta 1) i srodnim hormonom IGF-2. On pripada velikoj klasi tirozinsko kinaznih receptora . Ovaj receptor posreduje dejstvo IGF-1, koji je polipeptidni proteinski hormon sličan insulinu. IGF-1 utiče na razviće i nastavlja da vrši anaboličko dejstvo kod odraslih. On može da indukuje hipertroifju skeletalnih mišića i drugih ciljnih tkiva. Miševi bez IGF-1 receptora umiru u kasnijem periodu razvića, i manifestuju dramatičnu redukcu telesne mase, što potvrđuje jak uticaj ovog receptora. Miševi sa samo jednom funkcionalnom kopijom IGF1R su normalni, ali ispoljavaju ~15% umanjenje telesne mase.

Interakcije

Receptor insulinu sličnog faktora rasta 1 formira interakcije sa SOCS3,[1] PTPN11,[2][3] SOCS2,[4] GRB10,[5][6][7][8] PIK3R3,[9] C-src tirosinska kinaza,[10] EHD1,[11] Cbl genom,[12] RAS p21 proteinskim aktivatorom 1,[3] IRS1,[2][6][13] ARHGEF12,[14] YWHAE,[15] Mdm2,[12] SHC1[6][13][16] i NEDD4.[5][12]

Regulacija

Postoji evidencija da je IGF1R negativno regulisan dejstvom mikroRNK miR-7.[17]

References

  1. ↑ Dey, B R; Furlanetto R W, Nissley P (November 2000). „Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor”. Biochem. Biophys. Res. Commun. (UNITED STATES) 278 (1): 38–43. DOI:10.1006/bbrc.2000.3762. ISSN 0006-291X. PMID 11071852. 
  2. ↑ 2,0 2,1 Mañes, S; Mira E, Gómez-Mouton C, Zhao Z J, Lacalle R A, Martínez-A C (April 1999). „Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility”. Mol. Cell. Biol. (UNITED STATES) 19 (4): 3125–35. ISSN 0270-7306. PMC 84106. PMID 10082579. 
  3. ↑ 3,0 3,1 Seely, B L; Reichart D R, Staubs P A, Jhun B H, Hsu D, Maegawa H, Milarski K L, Saltiel A R, Olefsky J M (August 1995). „Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein”. J. Biol. Chem. (UNITED STATES) 270 (32): 19151–7. DOI:10.1074/jbc.270.32.19151. ISSN 0021-9258. PMID 7642582. 
  4. ↑ Dey, B R; Spence S L, Nissley P, Furlanetto R W (September 1998). „Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor”. J. Biol. Chem. (UNITED STATES) 273 (37): 24095–101. DOI:10.1074/jbc.273.37.24095. ISSN 0021-9258. PMID 9727029. 
  5. ↑ 5,0 5,1 Vecchione, Andrea; Marchese Adriano, Henry Pauline, Rotin Daniela, Morrione Andrea (May 2003). „The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor”. Mol. Cell. Biol. (United States) 23 (9): 3363–72. DOI:10.1128/MCB.23.9.3363-3372.2003. ISSN 0270-7306. PMC 153198. PMID 12697834. 
  6. ↑ 6,0 6,1 6,2 Dey, B R; Frick K, Lopaczynski W, Nissley S P, Furlanetto R W (June 1996). „Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10”. Mol. Endocrinol. (UNITED STATES) 10 (6): 631–41. DOI:10.1210/me.10.6.631. ISSN 0888-8809. PMID 8776723. 
  7. ↑ He, W; Rose D W, Olefsky J M, Gustafson T A (March 1998). „Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains”. J. Biol. Chem. (UNITED STATES) 273 (12): 6860–7. DOI:10.1074/jbc.273.12.6860. ISSN 0021-9258. PMID 9506989. 
  8. ↑ Morrione, A; Valentinis B, Li S, Ooi J Y, Margolis B, Baserga R (July 1996). „Grb10: A new substrate of the insulin-like growth factor I receptor”. Cancer Res. (UNITED STATES) 56 (14): 3165–7. ISSN 0008-5472. PMID 8764099. 
  9. ↑ Mothe, I; Delahaye L, Filloux C, Pons S, White M F, Van Obberghen E (December 1997). „Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins”. Mol. Endocrinol. (UNITED STATES) 11 (13): 1911–23. DOI:10.1210/me.11.13.1911. ISSN 0888-8809. PMID 9415396. 
  10. ↑ Arbet-Engels, C; Tartare-Deckert S, Eckhart W (February 1999). „C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor”. J. Biol. Chem. (UNITED STATES) 274 (9): 5422–8. DOI:10.1074/jbc.274.9.5422. ISSN 0021-9258. PMID 10026153. 
  11. ↑ Rotem-Yehudar, R; Galperin E, Horowitz M (August 2001). „Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29”. J. Biol. Chem. (United States) 276 (35): 33054–60. DOI:10.1074/jbc.M009913200. ISSN 0021-9258. PMID 11423532. 
  12. ↑ 12,0 12,1 12,2 Sehat, Bita; Andersson Sandra, Girnita Leonard, Larsson Olle (July 2008). „Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis”. Cancer Res. (United States) 68 (14): 5669–77. DOI:10.1158/0008-5472.CAN-07-6364. PMID 18632619. 
  13. ↑ 13,0 13,1 Tartare-Deckert, S; Sawka-Verhelle D, Murdaca J, Van Obberghen E (October 1995). „Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system”. J. Biol. Chem. (UNITED STATES) 270 (40): 23456–60. DOI:10.1074/jbc.270.40.23456. ISSN 0021-9258. PMID 7559507. 
  14. ↑ Taya, S; Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K (November 2001). „Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF”. J. Cell Biol. (United States) 155 (5): 809–20. DOI:10.1083/jcb.200106139. ISSN 0021-9525. PMC 2150867. PMID 11724822. 
  15. ↑ Craparo, A; Freund R, Gustafson T A (April 1997). „14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner”. J. Biol. Chem. (UNITED STATES) 272 (17): 11663–9. DOI:10.1074/jbc.272.17.11663. ISSN 0021-9258. PMID 9111084. 
  16. ↑ Santen, R J; Song R X, Zhang Z, Kumar R, Jeng M-H, Masamura A, Lawrence J, Berstein L, Yue W (July 2005). „Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity”. Endocr. Relat. Cancer. 12 (England) Suppl 1 (Supplement_1): S61–73. DOI:10.1677/erc.1.01018. ISSN 1351-0088. PMID 16113100. 
  17. ↑ Jiang, Lu; Liu, Xiqiang; Chen, Zujian; Jin, Yi; Heidbreder, Caroline E.; Kolokythas, Antonia; Wang, Anxun; Dai, Yang i dr.. (2010). „MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells”. Biochemical Journal 432 (1): 199–205. DOI:10.1042/BJ20100859. PMID 20819078. 

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