PDGFRA

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Receptor faktora rasta izvedenog iz trombocita, alfa polipeptid
Dostupne strukture
1GQ5
Identifikatori
SimboliPDGFRA; CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Vanjski IDOMIM: 173490 MGI: 97530 HomoloGene: 31361 GeneCards: PDGFRA Gene
EC broj2.7.10.1
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez515618595
EnsemblENSG00000134853ENSMUSG00000029231
UniProtP16234P26618
Ref. Sekv. (iRNK)NM_006206NM_001083316
Ref. Sekv. (protein)NP_006197NP_001076785
Lokacija (UCSC)Chr 4:
55.1 - 55.16 Mb		Chr 5:
75.15 - 75.2 Mb
PubMed pretraga[1][2]

Receptor alfa-tipa iz trombocida izvedenog faktora rasta je protein koji je kod ljudi kodiran PDGFRA genom.

Ovaj gen kodira tirozinsko kinazni receptor sa ćelijske površine za članove familije faktora rasta izvedene iz trombocita. Ti faktori rasta su mitogeni za ćelije mesenhimalnog porekla. Identitet faktora rasta vezanog za receptorski monomer određuje da li je funkcionalni receptor homodimer ili heterodimer, koji se sastoji od receptora i beta polipeptida. Studije na nokaut-miševima, kod kojih je homozigotnost letalna, indiciraju da je alfa forma receptora iz trombocita izvedenog faktora rasta posebno važna za razviće bubrega.[1]

Interakcije

PDGFRA formira interakcije sa PDGFRB,[2][3] PLCG1,[4] Natrijum-vodonik antiporter 3 regulator 1,[5] Cbl gene,[6] CRK,[7][8] Kaveolin 1[9] and PDGFC.[10]

Reference

  1. ↑ „Entrez Gene: PDGFRA platelet-derived growth factor receptor, alpha polypeptide”. 
  2. ↑ Rupp, E; Siegbahn A; Rönnstrand L; Wernstedt C; Claesson-Welsh L; Heldin C H (October 1994). „A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex”. Eur. J. Biochem. (GERMANY) 225 (1): 29–41. DOI:10.1111/j.1432-1033.1994.00029.x. ISSN 0014-2956. PMID 7523122. 
  3. ↑ Seifert, R A; Hart C E; Phillips P E; Forstrom J W; Ross R; Murray M J; Bowen-Pope D F (May 1989). „Two different subunits associate to create isoform-specific platelet-derived growth factor receptors”. J. Biol. Chem. (UNITED STATES) 264 (15): 8771–8. ISSN 0021-9258. PMID 2542288. 
  4. ↑ Eriksson, A; Nånberg E; Rönnstrand L; Engström U; Hellman U; Rupp E; Carpenter G; Heldin C H i dr.. (March 1995). „Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors”. J. Biol. Chem. (UNITED STATES) 270 (13): 7773–81. DOI:10.1074/jbc.270.13.7773. ISSN 0021-9258. PMID 7535778. 
  5. ↑ Maudsley, S; Zamah A M; Rahman N; Blitzer J T; Luttrell L M; Lefkowitz R J; Hall R A (November 2000). „Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity”. Mol. Cell. Biol. (UNITED STATES) 20 (22): 8352–63. DOI:10.1128/MCB.20.22.8352-8363.2000. ISSN 0270-7306. PMC 102142. PMID 11046132. 
  6. ↑ Bonita, D P; Miyake S; Lupher M L; Langdon W Y; Band H (August 1997). „Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity”. Mol. Cell. Biol. (UNITED STATES) 17 (8): 4597–610. ISSN 0270-7306. PMC 232313. PMID 9234717. 
  7. ↑ Yokote, K; Hellman U; Ekman S; Saito Y; Rönnstrand L; Saito Y; Heldin C H; Mori S (March 1998). „Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins”. Oncogene (ENGLAND) 16 (10): 1229–39. DOI:10.1038/sj.onc.1201641. ISSN 0950-9232. PMID 9546424. 
  8. ↑ Matsumoto, T; Yokote K; Take A; Takemoto M; Asaumi S; Hashimoto Y; Matsuda M; Saito Y i dr.. (April 2000). „Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation”. Biochem. Biophys. Res. Commun. (UNITED STATES) 270 (1): 28–33. DOI:10.1006/bbrc.2000.2374. ISSN 0006-291X. PMID 10733900. 
  9. ↑ Yamamoto, M; Toya Y; Jensen R A; Ishikawa Y (March 1999). „Caveolin is an inhibitor of platelet-derived growth factor receptor signaling”. Exp. Cell Res. (UNITED STATES) 247 (2): 380–8. DOI:10.1006/excr.1998.4379. ISSN 0014-4827. PMID 10066366. 
  10. ↑ Gilbertson, D G; Duff M E, West J W, Kelly J D, Sheppard P O, Hofstrand P D, Gao Z, Shoemaker K, Bukowski T R, Moore M, Feldhaus A L, Humes J M, Palmer T E, Hart C E (July 2001). „Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor”. J. Biol. Chem. (United States) 276 (29): 27406–14. DOI:10.1074/jbc.M101056200. ISSN 0021-9258. PMID 11297552. 

Literatura

  • Hart CE, Bowen-Pope DF (1990). „Platelet-derived growth factor receptor: current views of the two-subunit model”. J. Invest. Dermatol. 94 (6 Suppl): 53S–57S. DOI:10.1111/1523-1747.ep12875065. PMID 2161888. 
  • Corless CL, Schroeder A, Griffith D, et al. (2005). „PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib”. J. Clin. Oncol. 23 (23): 5357–64. DOI:10.1200/JCO.2005.14.068. PMID 15928335. 
  • Lasota J, Miettinen M (2007). „KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)”. Semin Diagn Pathol 23 (2): 91–102. DOI:10.1053/j.semdp.2006.08.006. PMID 17193822.