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V-erb-b2 ptičiji eritroblastni leukemijski viralni onkogeni homolog 4
	; PDB prolaz baziran na 2ahx.
Dostupne strukture
	2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U
Identifikatori
Simboli	ERBB4; ALS19; HER4; p180erbB4
Vanjski ID	OMIM: 600543 MGI: 104771 HomoloGene: 21084 GeneCards: ERBB4 Gene
EC broj	2.7.10.1
Ontologija gena
Molekulska funkcija	• aktivnost proteinske tirozinske kinaze; • aktivnost transmembranske receptorske proteinske tirozinske kinaze; • vezivanje receptora epidermalnog faktora rasta;
Ćelijska komponenta	• ekstracelularni region; • nukleus; • nukleoplazma;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • transkripcija na DNK šablonu; • prenos signala;
Pregled RNK izražavanja
	podaci
Ortolozi

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Receptorska tirozinska proteinska kinaza erbB-4 je enzim koji je kod ljudi kodiran ERBB4 genom.^[1]^[2] Alternativno splajsovane varijante koje kodiraju različite proteinske izoforme su poznate; mada sve nisu izučene.^[3]

Interakcije

ERBB4 formira interakcije sa:

Reference

↑ Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (May 1995). „Localization of the human HER4/erbB-4 gene to chromosome 2”. Oncogene 10 (6): 1235–7. PMID 7700649.
↑ Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G (October 2006). „Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain”. Cell 127 (1): 185–97. DOI:10.1016/j.cell.2006.07.037. PMID 17018285.
↑ „Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)”.
↑ Garcia, R A; Vasudevan K; Buonanno A (March 2000). „The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (7): 3596–601. DOI:10.1073/pnas.070042497. ISSN 0027-8424. PMC 16285. PMID 10725395.
↑ Huang, Y Z; Won S, Ali D W, Wang Q, Tanowitz M, Du Q S, Pelkey K A, Yang D J, Xiong W C, Salter M W, Mei L (May 2000). „Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses”. Neuron (UNITED STATES) 26 (2): 443–55. DOI:10.1016/S0896-6273(00)81176-9. ISSN 0896-6273. PMID 10839362.
↑ Williams, Christopher C; Allison June G; Vidal Gregory A; Burow Matthew E; Beckman Barbara S; Marrero Luis; Jones Frank E (November 2004). „The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone”. J. Cell Biol. (United States) 167 (3): 469–78. DOI:10.1083/jcb.200403155. ISSN 0021-9525. PMC 2172499. PMID 15534001.
↑ Schulze, Waltraud X; Deng Lei; Mann Matthias (2005). „Phosphotyrosine interactome of the ErbB-receptor kinase family”. Mol. Syst. Biol. (England) 1 (1): 2005.0008. DOI:10.1038/msb4100012. PMC 1681463. PMID 16729043.
↑ Omerovic, Jasminka; Puggioni Eleonora M R; Napoletano Silvia; Visco Vincenzo; Fraioli Rocco; Frati Luigi; Gulino Alberto; Alimandi Maurizio (April 2004). „Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level”. Exp. Cell Res. (United States) 294 (2): 469–79. DOI:10.1016/j.yexcr.2003.12.002. ISSN 0014-4827. PMID 15023535.

Literatura

Carpenter G (2003). „ErbB-4: mechanism of action and biology”. Exp. Cell Res. 284 (1): 66–77. DOI:10.1016/S0014-4827(02)00100-3. PMID 12648466.
Culouscou JM, Plowman GD, Carlton GW i dr.. (1993). „Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor”. J. Biol. Chem. 268 (25): 18407–10. PMID 7689552.
Barbacci EG, Guarino BC, Stroh JG i dr.. (1995). „The structural basis for the specificity of epidermal growth factor and heregulin binding”. J. Biol. Chem. 270 (16): 9585–9. DOI:10.1074/jbc.270.16.9585. PMID 7721889.
Nagata K, Kohda D, Hatanaka H i dr.. (1994). „Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4”. EMBO J. 13 (15): 3517–23. PMC 395255. PMID 8062828.
Plowman GD, Culouscou JM, Whitney GS i dr.. (1993). „Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family”. Proc. Natl. Acad. Sci. U.S.A. 90 (5): 1746–50. DOI:10.1073/pnas.90.5.1746. PMC 45956. PMID 8383326.
Cohen BD, Green JM, Foy L, Fell HP (1996). „HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers”. J. Biol. Chem. 271 (9): 4813–8. DOI:10.1074/jbc.271.9.4813. PMID 8617750.
Andersson B, Wentland MA, Ricafrente JY i dr.. (1996). „A "double adaptor" method for improved shotgun library construction”. Anal. Biochem. 236 (1): 107–13. DOI:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC i dr.. (1997). „Large-Scale Concatenation cDNA Sequencing”. Genome Res. 7 (4): 353–8. DOI:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Elenius K, Paul S, Allison G i dr.. (1997). „Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation”. EMBO J. 16 (6): 1268–78. DOI:10.1093/emboj/16.6.1268. PMC 1169725. PMID 9135143.
Chang H, Riese DJ, Gilbert W i dr.. (1997). „Ligands for ErbB-family receptors encoded by a neuregulin-like gene”. Nature 387 (6632): 509–12. DOI:10.1038/387509a0. PMID 9168114.
Carraway KL, Weber JL, Unger MJ i dr.. (1997). „Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases”. Nature 387 (6632): 512–6. DOI:10.1038/387512a0. PMID 9168115.
Chow NH, Liu HS, Yang HB i dr.. (1997). „Expression patterns of erbB receptor family in normal urothelium and transitional cell carcinoma. An immunohistochemical study”. Virchows Arch. 430 (6): 461–6. DOI:10.1007/s004280050056. PMID 9230911.
Zhang D, Sliwkowski MX, Mark M i dr.. (1997). „Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4”. Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9562–7. DOI:10.1073/pnas.94.18.9562. PMC 23218. PMID 9275162.
Elenius K, Corfas G, Paul S i dr.. (1997). „A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester”. J. Biol. Chem. 272 (42): 26761–8. DOI:10.1074/jbc.272.42.26761. PMID 9334263.
Komurasaki T, Toyoda H, Uchida D, Morimoto S (1998). „Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4”. Oncogene 15 (23): 2841–8. DOI:10.1038/sj.onc.1201458. PMID 9419975.
Fiddes RJ, Campbell DH, Janes PW i dr.. (1998). „Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3”. J. Biol. Chem. 273 (13): 7717–24. DOI:10.1074/jbc.273.13.7717. PMID 9516479.
Jones JT, Ballinger MD, Pisacane PI i dr.. (1998). „Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis”. J. Biol. Chem. 273 (19): 11667–74. DOI:10.1074/jbc.273.19.11667. PMID 9565587.
Srinivasan R, Poulsom R, Hurst HC, Gullick WJ (1998). „Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types”. J. Pathol. 185 (3): 236–45. DOI:10.1002/(SICI)1096-9896(199807)185:3<236::AID-PATH118>3.0.CO;2-7. PMID 9771476.
Harari D, Tzahar E, Romano J i dr.. (1999). „Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase”. Oncogene 18 (17): 2681–9. DOI:10.1038/sj.onc.1202631. PMID 10348342.

[pmid7700649-1] Zimonjic DB, Alimandi M, Miki T, Popescu NC, Kraus MH (May 1995). „Localization of the human HER4/erbB-4 gene to chromosome 2”. Oncogene 10 (6): 1235–7. PMID 7700649.

[pmid17018285-2] Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G (October 2006). „Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain”. Cell 127 (1): 185–97. DOI:10.1016/j.cell.2006.07.037. PMID 17018285.

[entrez-3] „Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)”.

[pmid10725395-4] Garcia, R A; Vasudevan K; Buonanno A (March 2000). „The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (7): 3596–601. DOI:10.1073/pnas.070042497. ISSN 0027-8424. PMC 16285. PMID 10725395.

[pmid10839362-5] Huang, Y Z; Won S, Ali D W, Wang Q, Tanowitz M, Du Q S, Pelkey K A, Yang D J, Xiong W C, Salter M W, Mei L (May 2000). „Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses”. Neuron (UNITED STATES) 26 (2): 443–55. DOI:10.1016/S0896-6273(00)81176-9. ISSN 0896-6273. PMID 10839362.

[pmid15534001-6] Williams, Christopher C; Allison June G; Vidal Gregory A; Burow Matthew E; Beckman Barbara S; Marrero Luis; Jones Frank E (November 2004). „The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone”. J. Cell Biol. (United States) 167 (3): 469–78. DOI:10.1083/jcb.200403155. ISSN 0021-9525. PMC 2172499. PMID 15534001.

[pmid16729043-7] Schulze, Waltraud X; Deng Lei; Mann Matthias (2005). „Phosphotyrosine interactome of the ErbB-receptor kinase family”. Mol. Syst. Biol. (England) 1 (1): 2005.0008. DOI:10.1038/msb4100012. PMC 1681463. PMID 16729043.

[pmid15023535-8] Omerovic, Jasminka; Puggioni Eleonora M R; Napoletano Silvia; Visco Vincenzo; Fraioli Rocco; Frati Luigi; Gulino Alberto; Alimandi Maurizio (April 2004). „Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level”. Exp. Cell Res. (United States) 294 (2): 469–79. DOI:10.1016/j.yexcr.2003.12.002. ISSN 0014-4827. PMID 15023535.

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