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AXL receptorska tirozinska kinaza
	; PDB prikaz baziran na 2c5d.
Dostupne strukture
	2C5D
Identifikatori
Simboli	AXL; JTK11; UFO
Vanjski ID	OMIM: 109135 MGI: 1347244 HomoloGene: 7583 GeneCards: AXL Gene
EC broj	2.7.10.1
Ontologija gena
Molekulska funkcija	• fosfatidilserinsko vezivanje; • aktivnost transmembranske receptorske proteinske tirozinske kinaze; • proteinsko vezivanje;
Ćelijska komponenta	• ekstracelularni prostor; • integralna komponenta ćelijske membrane; • ćelijska površina;
Biološki proces	• neuronska migracija; • diferencijacija prirodni ćeija ubica; • pozitivna regulacija citokinom posredovanog signalnog puta;
Pregled RNK izražavanja
	podaci
Ortolozi

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Tirozinski proteinski kinazni receptor UFO je enzim koji je kod ljudi kodiran AXL genom.^[1]^[2]

Funkcija

Protein kodiran ovim genom je član familije receptorskih tirozinskih kinaza. Mada je sličan drugim receptorskim tirozinskim kinazama, Axl protein ima jedinstvenu strukturu ekstracelularnog regiona koja postavlja jedno uz drugo IgL i FNIII ponavljanja. Ovaj receptor prenosi signale iz ekstracelularnog matriksa u citoplazmu u responsu na vezivanje faktora rasta. On učestvuje u stimulaciji ćelijske proliferacije. Ovaj receptor takođe može da posreduje ćelijsku agregaciju putem homofilnog vezivanja. Axl je onkogen asociran sa hroničnom mijelogenom leukemijom, kao i rakom debelog creva i melanomom. Njegov gen je lociran u blizini bcl3 onkogena, koje je u 19q13.1-q13.2. Axl gen je evoluciono konzerviran među kičmenjačkim vrstama. Poznate su dve različite alternativno splajsovane transkriptne varijante.^[2]

Interakcije

AXL receptorska tirozinska kinaza formira interakcije sa TENC1.^[3] Axl je regulator indukovanja esencijalni epitelijalno mesenhimalne tranzicije kod matastaze raka dojke.^[4]

Reference

↑ O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R 3rd, Le Beau MM, Earp HS, Liu ET (Oct 1991). „axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase”. Mol Cell Biol 11 (10): 5016–31. PMC 361494. PMID 1656220.
↑ ^2,0 ^2,1 „Entrez Gene: AXL AXL receptor tyrosine kinase”.
↑ Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2002). „Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin”. Biochem. Biophys. Res. Commun. 299 (5): 793–800. DOI:10.1016/S0006-291X(02)02718-3. PMID 12470648.
↑ Vajkoczy P, Knyazev P, Kunkel A, Capelle HH, Behrndt S, von Tengg-Kobligk H, Kiessling F, Eichelsbacher U, Essig M, Read TA, Erber R, Ullrich A (2006). „Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival”. Proc. Natl. Acad. Sci. U.S.A. 103 (15): 5799–804. DOI:10.1073/pnas.0510923103. PMC 1458653. PMID 16585512.

Literatura

Neubauer A, Burchert A, Maiwald C, et al. (1997). „Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias.”. Leuk. Lymphoma 25 (1–2): 91–6. DOI:10.3109/10428199709042499. PMID 9130617.
Bergsagel PL, Victor-Kobrin C, Timblin CR, et al. (1992). „A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells”. J. Immunol. 148 (2): 590–6. PMID 1729376.
Janssen JW, Schulz AS, Steenvoorden AC, et al. (1991). „A novel putative tyrosine kinase receptor with oncogenic potential”. Oncogene 6 (11): 2113–20. PMID 1834974.
Partanen J, Mäkelä TP, Alitalo R, et al. (1991). „Putative tyrosine kinases expressed in K-562 human leukemia cells”. Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8913–7. DOI:10.1073/pnas.87.22.8913. PMC 55070. PMID 2247464.
Neubauer A, Fiebeler A, Graham DK, et al. (1994). „Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis”. Blood 84 (6): 1931–41. PMID 7521695.
O'Bryan JP, Fridell YW, Koski R, et al. (1995). „The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage”. J. Biol. Chem. 270 (2): 551–7. DOI:10.1074/jbc.270.2.551. PMID 7822279.
Lee ST, Strunk KM, Spritz RA (1993). „A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes”. Oncogene 8 (12): 3403–10. PMID 8247543.
Schulz AS, Schleithoff L, Faust M, et al. (1993). „The genomic structure of the human UFO receptor”. Oncogene 8 (2): 509–13. PMID 8381225.
O'Bryan JP, Songyang Z, Cantley L, et al. (1996). „A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain”. Proc. Natl. Acad. Sci. U.S.A. 93 (7): 2729–34. DOI:10.1073/pnas.93.7.2729. PMC 39699. PMID 8610109.
Mark MR, Chen J, Hammonds RG, et al. (1996). „Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl”. J. Biol. Chem. 271 (16): 9785–9. DOI:10.1074/jbc.271.16.9785. PMID 8621659.
Braunger J, Schleithoff L, Schulz AS, et al. (1997). „Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site”. Oncogene 14 (22): 2619–31. DOI:10.1038/sj.onc.1201123. PMID 9178760.
Tanaka K, Nagayama Y, Nakano T, et al. (1998). „Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid”. Endocrinology 139 (3): 852–8. DOI:10.1210/en.139.3.852. PMID 9492013.
Yanagita M, Arai H, Ishii K, et al. (2001). „Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis”. Am. J. Pathol. 158 (4): 1423–32. DOI:10.1016/S0002-9440(10)64093-X. PMC 1891897. PMID 11290560.
Sun WS, Misao R, Iwagaki S, et al. (2003). „Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases, Axl and Sky, in human uterine endometrium and ovarian endometriosis”. Mol. Hum. Reprod. 8 (6): 552–8. DOI:10.1093/molehr/8.6.552. PMID 12029073.
D'Arcangelo D, Gaetano C, Capogrossi MC (2002). „Acidification prevents endothelial cell apoptosis by Axl activation”. Circ. Res. 91 (7): e4–12. DOI:10.1161/01.RES.0000036753.50601.E9. PMID 12364394.
Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). „Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin”. Biochem. Biophys. Res. Commun. 299 (5): 793–800. DOI:10.1016/S0006-291X(02)02718-3. PMID 12470648.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ito M, Nakashima M, Nakayama T, et al. (2003). „Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around chernobyl”. Thyroid 12 (11): 971–5. DOI:10.1089/105072502320908303. PMID 12490074.

[pmid1656220-1] O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R 3rd, Le Beau MM, Earp HS, Liu ET (Oct 1991). „axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase”. Mol Cell Biol 11 (10): 5016–31. PMC 361494. PMID 1656220.

[entrez-2] 2,0 ^2,1 „Entrez Gene: AXL AXL receptor tyrosine kinase”.

[pmid12470648-3] Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2002). „Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin”. Biochem. Biophys. Res. Commun. 299 (5): 793–800. DOI:10.1016/S0006-291X(02)02718-3. PMID 12470648.

[pmid16585512-4] Vajkoczy P, Knyazev P, Kunkel A, Capelle HH, Behrndt S, von Tengg-Kobligk H, Kiessling F, Eichelsbacher U, Essig M, Read TA, Erber R, Ullrich A (2006). „Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival”. Proc. Natl. Acad. Sci. U.S.A. 103 (15): 5799–804. DOI:10.1073/pnas.0510923103. PMC 1458653. PMID 16585512.

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