Nereceptorska tirozinska kinaza

Proteinska tirozinska kinaza koja ne premoštava membranu
Identifikatori
EC broj 2.7.10.2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
Ontologija gena AmiGO / EGO

Nereceptorske tirozinske kinaze (nespecifične proteinske tirozinske kinaze) su enzimi koji prenose fosfatnu grupu sa ATP-a na tirozinski ostatak proteina. Nereceptorske tirozinske kinaze su podgrupa veće klase tirozinskih kinaza. Fosforilacija proteina kinazama je važan mehanizam prenosa signala u regulaciji enzimske aktivnosti.[1][2]

Strukturne studije

Znatan broj struktura ove klase enzima je rešen: 2DM0, 2DQ7, 2E2B, 2E6I, 2EKX, 2GQG, 2H8H, 2HDA, 2HIW, 2HK5, 2HWO, 2HWP, 2HYY, 2HZ0, 2HZ4, 2HZI, 2HZN, 2IJM, 2IN6, 2IO6, 2J0J, 2J0K, 2J0L, 2J0M, 2O88, 2OF2, 2OF4, 2OFU, 2OFV, 2OG8, 2OI3, 2OIQ, 2OQ1, 2OZO, 2QOH, 2V7A, i 2Z60.

Reference

  1. ↑ Dan R Robinson, Yi-Mi Wu and Su-Fang Lin (2000). „The protein tyrosine kinase family of the human genome”. Oncogene 19: 5548-57. Arhivirano iz originala na datum 2013-01-02. Pristupljeno 2014-01-25. 
  2. ↑ Esther Zwick, Johannes Bange, Axel Ullrich (2002). Receptortyrosinekinases as targets for anticancer drugs. 8. pp. 17–23. 

Literatura

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