Proto-onkogen tirozinske proteinske kinaze MER je enzim koji je kod ljudi kodiran MERTKgenom.[1][2][3]
Ovaj gen je član familije MER/AXL/TYRO3 receptorskih kinaza. On kodira transmembranksi protein sa dva domena fibronektinskog tipa III, dva Ig slična C2-tip (imunoglobulinu slična) domena, i jednim tirozinskim kinaznim domenom. Mutacije ovog gena su uzrokuju poremećaje fagocitnog puta retinalnog pigmentnog epitela (RPE) i nastup autosomalne recesivne retinitisne pigmentoze (RP).[3]
Reference
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