Ceftarolina

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Ceftarolina
Caratteristiche generali
Formula bruta o molecolareC22H21N8O8PS4
Numero CAS229016-73-3
PubChem9852981 e 57514685
DrugBankDBDB06590
SMILES
CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]
Dati farmacologici
Modalità di
somministrazione		parenterale
Dati farmacocinetici
Metabolismorenale
Emivita2,6 ora
Escrezionerenale
Indicazioni di sicurezza
Simboli di rischio chimico
Infiammabile Irritante
attenzione
Modifica dati su Wikidata · Manuale

La ceftarolina fosamil è una cefalosporina di quinta generazione attiva nei confronti dello stafilococco aureo resistente alla meticillina, con indicazione nel trattamento delle infezioni complicate dei tessuti molli.

Il suo nome commerciale è Zinforo.

Farmacodinamica

L'efficacia del farmaco è data dalla inibizione della parete cellulare batterica. Il farmaco studiato contro le infezioni da stafilococco multiresistenti ha anche però un ampio spettro d'azione che comprende streptococchi, pneumococchi, enterococchi e praticamente ogni enterobacteriacea; non è inibito da penicillasi e altre betalattamasi. A differenza del ceftobiprolo la sua attività su Pseudomonas aeruginosa, Providencia, Enterobacter cloacae e Proteus vulgaris non è apprezzabile.

Farmacocinetica

La ceftarolina ha un basso legame plasmatico (1-19%). Il farmaco è eliminato per via renale e ha un'emivita di 2,6 ore. Il farmaco ha ottime concentrazioni nei polmoni. Si somministra unicamente per via parenterale.

Collegamenti esterni

  Portale Chimica

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