Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal...

with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha...

CD49b gene. The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane...

Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103...

Integrin α4β7 (Lymphocyte Peyer’s patch adhesion molecule-1) is an integrin heterodimer composed of CD49d (alpha-4) subunit and beta-7 subunit noncovalently...

to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7), blocking the α4β7 integrin results...

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a...

antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2). The...

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain...

also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain...

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes. The...

Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta...

In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one...

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are...

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alpha integrin. Integrins are heterodimeric integral...

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin...

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins...

targets (i.e., binds to) the cell surface receptor αvβ6-integrin and accumulates in αvβ6-integrin-abundant tissues after intravenous (i.v.) application...

Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)...

contain integrin α6β4 and plectin without the BP antigens. Hemidesmosomes have two membrane-spanning components: Integrin α6β4 and BPAG2. Integrin α6β4 operates...

adhesion molecules of the immune system, the first relationships among integrins—between LFA-1 and Mac-1—and the three-step model for leukocyte emigration...

In cell biology, CD11 is the α (alpha) component of various integrins, especially ones in which the β (beta) component is CD18 (β2) and mediate leukocyte...

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans...

Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 subunit is 155 kDa, and the...

Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are...

facilitated through the binding of multiple β1 chain integrins. The interplay between invasin and β1 integrins initiates a reconfiguration of the cytoskeleton...

codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, although with...

encodes a subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5...

Integrin-like receptors (ILRs) are found in plants and carry unique functional properties similar to true integrin proteins. True homologs of integrins...

matrix such as fibronectin and hyaluronan can also bind to such receptors (integrins and CD44, respectively). In addition, some molecules such as steroid hormones...

Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7...

Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene. GRCh38: Ensembl release 89: ENSG00000156886 – Ensembl, May 2017 GRCm38: Ensembl...

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are...

Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene. This gene encodes a beta integrin-related protein that is a member...

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins...

groups of CAMs: the immunoglobulin superfamily (IgSF CAMs), cadherins, integrins, and the superfamily of C-type of lectin-like domains proteins (CTLDs)...

species ranging from Drosophila to humans. Cell adhesion proteins called integrins recognize and bind to this sequence, which is found within many matrix...

αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed...

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes...

known as integrins. Integrins are cell-surface proteins that bind cells to ECM structures, such as fibronectin and laminin, and also to integrin proteins...

activity based on physical pressures. Extracellular matrix linked proteins - integrins and focal adhesions can transmit forces from the linked extracellular...

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene...

to membranes where integrins are found. This provides a mechanism by which Rap1 can act directly on integrins and modulate integrin affinity and/or clustering...

major contributions in the field of adhesion molecules, focusing on the integrins expressed by leukocytes. Hogg was elected to the Academy of Medical Sciences...

medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a transmembrane receptor...

integrins to participate in latent TGF-β1 activation, arose from studies that examined mutations/knockouts of β6 integrin, αV integrin, β8 integrin and...

switching by means of overlapping motifs (e.g. the C-terminal tails of integrin beta subunits), or they can allow high avidity interactions by multiple...

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane...

of integrins participating in latent TGF-β1 activation arose from studies that examined mutations/knockouts of β6 integrin, αV integrin, β8 integrin and...

adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid...

antibody, which binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7) on T lymphocytes...

extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as...

mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered expression of talin-1 has been...

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017 GRCm38: Ensembl...

migration. Alpha-7 integrin pericytes (AIPs) express several types of integrin chains which generate heterodimers. Integrin chains allow integrin pericytes to...

the binding site for von Willebrand factor (vWF), α-thrombin, leukocyte integrin αMβ2 and P-selectin. The binding between GPIbα and vWF mediates the capture...

Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins...

immune response. This process relies on the key interaction between the integrin α4β7 and the addressin MadCAM-1 on the surfaces of the appropriate cells...

developed by Gilead Sciences for the treatment of ulcerative colitis. It is an integrin alpha4/beta7 antagonist. "Emvistagrast - Gilead Sciences - AdisInsight"...

noncovalently bound. Collagen binding is primarily provided by integrins α1β1, α2β1, α10β1 and α11β1. Integrin α1β1 binds to collagen via the MIDAS motif in the α...

the Power Rangers franchise Integrin alpha-5, a protein encoded by the ITGA5 gen in humans Alpha-5 beta-1 (α5β1), an integrin that binds to matrix macromolecules...

increased stiffness substrates. Growth cones utilize integrin migratory machinery such as integrins, but are not a class of cell migration. Thy-1 (or CD90...

called integrins and her findings support that epidermal α3β1 integrin is required for the prevention of blistering diseases and that αvβ3-integrin is required...

Vitaxin (MEDI-523) is a humanized monoclonal antibody against the vascular integrin alpha-v beta-3. It is shown to be a promising angiogenesis inhibitor used...

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene. The protein encoded by this...

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene and is located in chromosome 15. The protein encoded by...

carotegrast, by the enzyme carboxylesterase 1 in the liver. Carotegrast is an α4-integrin antagonist which prevents the chronic inflammation affecting the gastrointestinal...

a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. It is given by intravenous infusion. The drug is believed to work by reducing...

are responsible for cell to cell crosstalk via cell-cell contacts and integrin mediated cell adhesion through focal adhesion proteins and as specialised...

direct numerous signaling proteins at sites of integrin binding and clustering. Focal adhesions are integrin-containing, multi-protein structures that form...

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain family and encodes a single-pass...

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. Integrins are integral membrane proteins composed of...

Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene. The cytoplasmic domains of integrins are essential for...

Cell Biology at Yale University. His research focuses on cell adhesion, integrin signaling, mechanotransduction, and vascular biology, particularly the...

used to silence the genes integrin α2 and integrin β1, reducing the expression of the integrin subunits. Blocking integrin α2/β1 stopped S. moorei's cancer-promoting...

differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development...

exhibit impaired "outside-in" signalling through αIIbβ3, the major platelet integrin. It is hypothesized that tetraspanins interact with and regulate other...

Cell adhesion molecules (CAMs) are classified into four major families: integrins, immunoglobulin superfamily, cadherins, and selectins. Cadherins and IgSF...

juxtacrine activation of integrins by chemokines and soluble factors released by endothelial cells. In the activated state, integrins bind tightly to complementary...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which...

of the protein-protein interaction between fibrinogen and the platelet integrin receptor GP IIb/IIIa and is the first drug candidate whose origins can...

Intetumumab is a human monoclonal antibody targeting integrins that was being studied for the treatment of solid tumors. Intetumumab was developed by...

fibronectin, and perlecan. The proteins also bind to cell membranes through integrins and other plasma membrane molecules, such as the dystroglycan glycoprotein...

sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced...

bind to cell surface receptor proteins called integrins that are built into the plasma membrane. Integrins span the membrane and bind on the cytoplasmic...

protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of...

nephrologist best known for seminal discoveries in the biology and structure of integrin receptors. He is Professor of Medicine at Harvard Medical School and Physician...

aims to find novel regulators for integrin activity, understanding the integrin traffic, and link between integrin activity regulation and mechanosensing...

to detect substrate stiffness and modulate behavior through the calpain-integrin-E-cadherin pathway. Beginning with the activation of calpain, a protease...

cytoplasm, but in contrast to desmosomes, their transmembrane anchors are integrins rather than cadherins. Adherens junctions share the characteristic of...

ulcerative colitis. The other main categories of biologics that treat IBD are integrin receptor antagonists such as vedolizumab and natalizumab and interleukin...

have an inherited molecular defect that causes a deficiency of the β-2 integrin subunit, also called CD18, which is encoded by the ITGB2 gene found on...

important activator of TGF-β is αvβ6-integrin, which releases TGF-β from its latent form. Hence, αvβ6-integrin has been recognized earlier as a potential...

Cdc42 with rapid involvement of integrins of the β1 family; 2) occurrence of focal adhesion with the involvement of integrins β1 and β3 at the contact site...

Moperone Luvatren butyrophenone N05AD04 Oxypertine Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil phenylpiperazine N05AE01 Oxyprothepine Meclopin...

solid tumors. It binds to and inhibits the functional activity of α5β1 integrin. It is thought to reduce metastases. Early results show potential in renal...

the F protein has been proven by its ability to bind to host cells via integrin αvβ1 using an Arginine-Glycine-Aspartate (RGD) motif, which is speculated...

"Flatshark reste sig ur ruinerna av Grin" [Fatshark rose from the ruin of Integrin] (in Swedish). IDG.se. Retrieved 10 September 2012. "Exclusive Interview...

thrombin-cleaved OPN (OPN-R) exposes an epitope for integrin receptors of α4β1, α9β1, and α9β4. These integrin receptors are present on a number of immune cells...

Increased levels of laminin-111 triggered an increase in the expression of α7-integrin receptor and this prevented onset of the disease. Additionally, the presence...

shape change. A major task of kindlins is to regulate the activation of integrins. FERMT2 has been shown to interact with FBLIM1. Loss of kindlin-2 in mice...

structures of 4-disulfide EGF-domains have been solved from the laminin and integrin proteins.[citation needed] The main structure of EGF-like domains is a...

thicker, with strong adhesion to epithelial cells via binding to integrin and non-integrin receptors. When side branches develop, it is a much more "pushing-forward"...

cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3. CD154 acts as a costimulatory molecule and is particularly...

American biologist, focusing in cardiac gap junction membrane channels, integrin water channels, rotavirus, reovirus and retrovirus. Yeager is a professor...

expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus...

is associated with abnormal integrin αIIbβ3, formerly known as glycoprotein IIb/IIIa (GpIIb/IIIa), which is an integrin aggregation receptor on platelets...

phosphorylated in response to integrin engagement, growth factor stimulation, and the action of mitogenic neuropeptides. Integrin receptors are heterodimeric...

Abituzumab is a humanized IgG2 monoclonal antibody (mAb) targeted at CD51 (an integrin) currently in development by Merck KGaA Darmstadt, Germany in an attempt...

with an integrin molecule. It is the co-receptor interaction that stimulates entry of the adenovirus. This co-receptor molecule is αV integrin. Binding...

It consists of two components, integrin alpha V and integrin beta 5. Sheppard D (October 2002). "Endothelial integrins and angiogenesis: not so simple...

venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion. Disintegrins work by countering the blood clotting...

can be detected in supernatant or blood plasma. ISG15 binds the LFA-1 integrin receptor on NK- and T-cells to potentiate their production of IFN-II, which...

I and III. The C4 domain: Contains an RGD motif that binds to platelet integrin αIIbβ3. The CK (cystine knot) domain at the protein's C-terminal end: Involved...

an American scientist, focusing in molecular structure and function of integrins in immune responses and rheumatology. He is a Distinguished Professor...

β1 integrins. Collagen XXIII interacts in an ion-and conformation-dependent manner with integrin α2β1. Integrin α2β1 is a collagen-binding integrin present...

called bone sialoprotein 2 also known as cell-binding sialoprotein or integrin-binding sialoprotein and is encoded by the IBSP gene. Native BSP has an...

immunoglobulin superfamily (IgSF), the members of which are ligands for integrins. The crystal structure of this domain has been reported; it adopts an...

binding to integrins. MFGE8 binds PS, which is exposed on the surface of apoptotic cells. Opsonization of the apoptotic cells and binding to integrins on the...

expression data BioGPS n/a Gene ontology Molecular function calcium ion binding integrin binding extracellular matrix structural constituent Cellular component...

on the central nervous system. Safrole oxide inhibits the expression of integrin β4/SOD, leading to apoptosis of the nerve cells. Safrole is listed as a...

outside the cell to inside the cell by integrin. FYB can also bind to SKAP1, which allows SKAP1 to upregulate integrin activity through interactions with...

endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of integrins. VCAM-1 expression has also been observed in other...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

and bone. In humans it is encoded by the VTN gene. Vitronectin binds to integrin alpha-V beta-3 and thus promotes cell adhesion and spreading. It also inhibits...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

dystrophin-glycoprotein complex (DGC) and the integrin-vinculin-talin complex. The sarcoglycans of the DGC and the integrins of the integrin-vinculin-talin complex attach...

Bahamas (1989) Integrin heterodimer and receptor complexity in avian and mammalian cells (1989) Analysis and distribution of integrins in chicken embryos...

Other extracellular matrix components such as matrix metalloproteins and integrins are also frequently co-expressed with TN-C. In the developing central...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

the production of specific proteins. Additionally, the hormone binds to integrin αvβ3 on the cell membrane, thereby stimulating the sodium–hydrogen antiporter...

cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. Integrins are a family of receptor proteins that integrate the...

gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000...

respectively. JAMs adhere to adjacent cells through interactions with integrins LFA-1 and Mac-1, which are contained in leukocyte β2 and α4β1, which is...

based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and...

saliva of ticks also contains anticoagulant and antiplatelet proteins (integrin inhibitors), to stop the blood from coagulating while they suck. Most ticks...

"Canine Chondrodysplasia Caused by a Truncating Mutation in Collagen-Binding Integrin Alpha Subunit 10". PLoS ONE. 8 (9) e75621. Public Library of Science (PLoS)...

(2001). "Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1"...

trophoblast have binding fiber connections, laminin, collagen type IV, and integrins that assist in this adhesion process. Mucin-16 is a transmembrane mucin...

compounds with potential antiplatelet activity directed at the platelet integrin αIIbβ3 protein complex (also known as glycoprotein IIb/IIIa). Among more...

Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains". J. Biol. Chem...

regulates the reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and secondary messengers. At least...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

of cell adhesion positive regulation of cell-cell adhesion mediated by integrin glomerular visceral epithelial cell development negative regulation of...

of plasma membrane called integrin-mediated focal adhesions (which are formed around a transmembrane core of an αβ integrin heterodimer). Genome sequencing...

matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin". EMBO J. 17 (6): 1606–13. doi:10.1093/emboj/17...

not listed on hcdm Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human CD51 Antibody...

demethylation involves the DNA base excision repair pathway. Trophoblasts express integrin on their cell surfaces which allow for adhesion to the extracellular matrix...

to specific cell-surface receptors such as C-type lectins, DC-SIGN, or integrins, which is followed by fusion of the viral envelope with cellular membranes...

"Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer". Neoplasia. 10 (11): 1259–67. doi:10.1593/neo.08740...

Vatelizumab is an immunomodulator. It binds to integrin alpha 2. It was withdrawn from Phase II trials for inflammatory bowel disease due to a lack of...

Annexin A5 has been shown to interact with Kinase insert domain receptor and Integrin, beta 5. GRCh38: Ensembl release 89: ENSG00000164111 – Ensembl, May 2017...

also necessary. Primary receptors include DC-SIGN, DC-SIGN-R, and the integrin αvβ3. By binding to these primary receptors, WNV enters the cell through...

assembly negative regulation of GTPase activity regulation of ruffle assembly integrin-mediated signaling pathway positive regulation of G2/M transition of mitotic...

process platelet activation negative regulation of signal transduction integrin-mediated signaling pathway blood coagulation erythrocyte differentiation...

interact) on the target cell surface. Gp120 binds to integrin α4β7 activating LFA-1, the central integrin involved in the establishment of virological synapses...

"Canine Chondrodysplasia Caused by a Truncating Mutation in Collagen-Binding Integrin Alpha Subunit 10". PLoS ONE. 8 (9) e75621. Public Library of Science (PLoS)...

Jones, Robert E.; Lahr, Daniel J. G.; Brown, Matthew W. (2021-07-26). "The integrin-mediated adhesive complex in the ancestor of animals, fungi, and amoebae"...

domain Malfunctions : tumor – oncogene – tumor suppressor gene Receptors : Integrin – transmembrane receptor – ion channel Techniques : electrophoresis – chromatography...

presumed through a direct association with the cytoplasmic tail of beta-integrin. The N-terminal region of paxillin is rich in protein–protein interaction...

Dendritic cell-specific intracellular adhesion molecule-3-grabbing non-integrin) have been identified as viral entry components in some orthobunyaviruses...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

various cell surface receptors in a context-dependent manner, including integrin receptors, cell surface heparan sulfate proteoglycans (HSPGs), LRPs, and...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

viral glycoprotein spikes to host cell receptors, particularly β1 and β3 integrins. Decay acceleration factors, complement receptors, and, for New World...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

disease. In particular, circulating cells which are CD11b (also known as integrin alpha) expressive are reduced in susceptible individuals. CD11b has a vital...

PMID 10591208. Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage...

pioneering discoveries of cell adhesion molecules, Hynes and Ruoslahti for integrins and Takeichi for cadherins." Massachusetts Institute of Technology Howard...

immune system. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through...

in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular...

hemorrhagins; (iii) angioneurin growth factors; and (iv) different types of integrin inhibitors. The copulation of this snake takes place around May. Unlike...

fibronectin binding receptor ligand activity endopeptidase activator activity integrin binding enzyme activator activity G protein-coupled receptor activity Wnt-protein...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

Molecular function insulin-like growth factor binding growth factor activity integrin binding heparin binding Cellular component extracellular region extracellular...

membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal...

domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This...

microbiologist and immunologist, focusing in structure and biology of integrin adhesive receptors for extracellular matrix proteins, currently the Dorothy...

CA-125 (imitation) ovarian cancer Abciximab ReoPro Fab chimeric CD41 (integrin alpha-IIb) Y platelet aggregation inhibitor Abituzumab mab humanized CD51...

mitochondrion protein-containing complex Biological process vasculogenesis integrin-mediated signaling pathway inner ear development endothelial tube morphogenesis...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

to enhance integrin binding and signaling and stem cell differentiation. Increasing the density of ligand clustering also increased integrin binding. A...

BMRF-2 interacts with cellular β1 integrins. Then, viral protein gH/gL interacts with cellular αvβ6/αvβ8 integrins. This triggers fusion of the viral...

monoclonal antibody that acts on the cardiovascular system. It binds to integrin αIIbβ3, a fibrinogen and fibronectin receptor found on platelets. The drug...

Santoro (M.D./Ph.D. 1979) – pioneering researcher in the structure of integrin adhesive receptors for extracellular matrix proteins, chair of the department...

cells. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results...

and likely to inhibit adhesion. It binds to adhesion proteins such as integrins and blocks further binding to other cells or the extracellular matrix...

to other cells and to the ECM. Transmembrane receptor proteins called integrins, which are made of glycoproteins and normally anchor the cell to the basement...

cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved...

function Cellular component integral component of membrane cell surface integrin alphaIIb-beta3 complex integral component of plasma membrane intracellular...

receptors that activates integrins on the leukocyte surface for firm adhesion. Such activation increases the affinity of bound integrin receptors for ICAM-1...

kills granulocytes, monocytes, and other white blood cells expressing integrin beta-2 (CD18) Cytolethal distending toxin Immunosuppression factors that...

pseudopodium can then adhere to a surface via its adhesion proteins (e.g. integrins), and then pull the cell's body forward via contraction of an actin-myosin...

to the ECM. They consist of three functional layers: an ECM-associated integrin layer, a membrane associated force transduction layer, and an actin layer...

SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM (Nov 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction"...

transendothelial migration, superoxide generation, and degranulation via beta2 integrin". Annals of Allergy, Asthma & Immunology. 93 (6): 594–600. doi:10...

polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J Cell Biol. 131 (3): 807–16. doi:10.1083/jcb.131.3.807...

system of a human immunodeficiency virus (HIV), it is shown to block the integrin-dependent processes. Ajoene has broad-spectrum antimicrobial (antibacterial...

due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact...

Koretzky GA, Peterson EJ (Dec 2004). "PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function". Mol Cell Biol. 24 (24): 10923–32. doi:10...

taste). Lifitegrast is supplied as an eye drop. Lifitegrast inhibits an integrin, lymphocyte function-associated antigen 1 (LFA-1), from binding to intercellular...

adhesion to tenascin-X mapping of cell adhesion sites and identification of integrin receptors". European Journal of Biochemistry. 263 (3): 840–848. doi:10...

2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". Journal...

bind to other receptors on the macrophage such as CD36 and alpha-v beta-3 integrin. Defects in apoptotic cell clearance is usually associated with impaired...

peptidase inhibitor activity enzyme inhibitor activity metal ion binding integrin binding protein binding protease binding metalloendopeptidase inhibitor...

patches is often mediated by L-selectin and limited expression of α4 integrins and other homing receptors prevents these lymphocytes from accessing mucosal...

plasma membrane membrane secretory granule membrane Biological process integrin-mediated signaling pathway macrophage activation involved in immune response...

assembly, as well as assembly of integrin adhesion complexes, which was attributed to disrupted interactions between integrins and the actin cytoskeleton....

called EV protein 1, EVER1), TMC8 (also called EVER2), or calcium- and integrin-binding protein 1 (CIB1). The EVER1 or EVER2 genes are located adjacent...

RGD motif is found in this protein, and this is potentially involved in integrin recognition. GRCh38: Ensembl release 89: ENSG00000152595 – Ensembl, May...

Strominger JL, Hemler ME (May 2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". The Journal...

"Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells". Immunity. 33 (5): 723–35. doi:10.1016/j...

from a diverse range of extracellular stimuli, including growth factors, integrin activation, vasoactive hormones and peptides ligands for G-protein coupled...

S2CID 40872647. Wang J, Brown EJ (August 1999). "Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A". The...

neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript...

epithelial cell proliferation positive regulation of cell adhesion mediated by integrin positive regulation of transcription by RNA polymerase II intraciliary...

molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1". J. Exp. Med. 196 (5): 679–91. doi:10.1084/jem.20020267. PMC 2194005...

by reversing of epithelial-mesenchymal transition via downregulation of integrin β3". Biomedical Journal. 44 (6 Suppl 1): S84–S92. doi:10.1016/j.bj.2020...

active molecule of MT1-MMP and auto catalytic cleavage. Clustering of integrin chains promotes activation of MMP-2. Another factor that will support the...

function hormone activity insulin receptor binding growth factor activity integrin binding protein binding insulin-like growth factor receptor binding Cellular...

may function as an integrin ligand in the brain. ADAM23 This gene is highly expressed in the brain and may function as an integrin ligand in the brain...

Glucose Transporters in Articular Chondrocytes (2008) Diverse Roles of Integrin Receptors in Articular Cartilage (2008) Potassium ion channels in articular...

the B. anthracis exosporium, which promotes inside-out activation of the integrin Mac-1, enhancing spore internalization by macrophages. This cascade results...

activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton". Carcinogenesis. 23 (10): 1593–1601. doi:10.1093/carcin/23...

Iyengar, Ravi; Geiger, Benjamin (August 2007). "Functional atlas of the integrin adhesome". Nature Cell Biology. 9 (8): 858–867. doi:10.1038/ncb0807-858...

by p53 class mediator negative regulation of cell adhesion mediated by integrin DNA damage response, signal transduction by p53 class mediator resulting...

PMID 13653007.; Hertzler, PL; McClay, DR (1999). "alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo". Developmental Biology. 207...

scar in bullous pemphigoid. Antibodies to the beta-4 integrin subunit of alpha-6-beta-4 integrin is shown to be associated with ocular disease while oral...

transmitted by focal adhesion sites, integrins, and cell-cell junctions. Changes in the actin cytoskeleton can activate integrins, which mediate "outside-in" and...

for anti-fibrotic therapy. CCN4 activates human cardiac fibroblasts via integrin β1-Akt signaling pathway to induce collagen deposition and promote fibrosis...

Fc-epsilon receptor signaling pathway positive regulation of apoptotic process integrin-mediated signaling pathway cellular response to DNA damage stimulus regulation...

DNA-templated cell adhesion nucleoside triphosphate biosynthetic process integrin-mediated signaling pathway GTP biosynthetic process regulation of epidermis...

picornaviruses, additional host factors may contribute to internalization; integrins have been identified as entry receptors for some enteroviruses. Enterovirus...

infection. Hands and fingers may be affected, as well as various joints. α6β4 integrin is a transmembrane protein found in hemidesmosomes. As a heterodimer molecule...

whereby the virion associates with putative receptors such as alpha integrins, laminins, and annexin A2 leading to the entry of the virions into basal...

subendothelium. Platelet GP1b-IX-V receptor binds with VWF; and GPVI receptor and integrin α2β1 bind with collagen. Factors from the lining of vessels stop platelets...

shows that plexins can also influence R-Ras, which, in turn, can regulate integrins. Such regulation is probably a common feature of semaphorin signalling...

"Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease". Nature Genetics. 49 (2): 256–261...

permeability by down-regulation of tight junction but not dependent on integrins induced focal adhesions". International Journal of Biological Sciences...

apolipoprotein(a): Roles of urokinase plasminogen activator receptor and integrins αMβ2 and αVβ3". Atherosclerosis. 275: 11–21. doi:10.1016/j.atherosclerosis...

David D.; Hanks, Steven K.; Hunter, Tony; Geer, Peter van der (1994). "Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal...

The calx-beta motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the...

contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras". J. Biol. Chem. 275 (7): 5222–7. doi:10.1074/jbc.275...

desmosomes but mediate cellular attachment to extracellular matrix. They use integrins instead of cadherins. Gap junctions connect the cytoplasm of adjacent...

"Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3)". Clin. Exp. Metastasis. 19 (2): 127–34. doi:10.1023/A:1014573204062...

example, integrin-mediated cytoskeleton assembly and even cell motility are affected by the physical state of the ECM. Binding of the α5β1 integrin to its...

Chung, Jun (2004). "Autocrine signaling in carcinoma: VEGF and the α6β4 integrin". Seminars in Cancer Biology. 14 (2): 115–22. doi:10.1016/j.semcancer.2003...

function calcium ion binding endopeptidase activity metal ion binding integrin binding peptidase activity protein binding metalloendopeptidase activity...

disease. It is a humanized monoclonal antibody against the β7 subunit of integrins α4β7 and αEβ7. Etrolizumab was developed by Genentech by engineering the...

alveolar epithelial cells, thus inducing the expression of the αvβ6 integrin. Integrins are dimeric cell-surface receptors composed of alpha and beta subunits...

a variety of cell surface receptors including CD74, Fc receptor, and integrins. Mice that lack Syk completely (Syk−/−, Syk-knockout) die during embryonic...

new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking". J. Biol. Chem. 270 (52): 30919–26. doi:10.1074/jbc.270...

on the activation of the cell membrane receptors TGR5, S1PR2 and α5β1-Integrin. Tauroursodeoxycholic acid also acts as a chemical chaperone to help maintain...

chemical bonds with endogenous proteins such as mucus glycoproteins, integrins or keratins via disulfide bridges. Because of their comparatively high...

MAC-1 may refer to: Macrophage-1 antigen Integrin alpha M Macintosh This disambiguation page lists articles associated with the same title formed as a...

reference expression data Gene ontology Molecular function heparin binding integrin binding protein binding growth factor activity calcium ion binding Cellular...

Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells. Periostin is a...

stress fiber assembly cell adhesion regulation of inflammatory response integrin-mediated signaling pathway cell-matrix adhesion viral process transforming...

Galbraith J. A. (February 2007). "Polymerizing actin fibers position integrins primed to probe for adhesion sites". Science. 315 (5814): 992–5. Bibcode:2007Sci...

Uemura N, Law SF, et al. (May 1997). "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)"...

and in interaction with AKT1), GSTP1, estrogen receptor beta, CBR1, and integrin αVβ. It was unclear at that time if any or all of these were responsible...

melanocytes attach to that protein instead of the normal laminin-211 (via an integrin receptor instead of dystroglycan). Rather than disappearing, melanocytes...

2010). "Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38...

BioGPS More reference expression data Gene ontology Molecular function integrin binding protein binding heparin binding chemoattractant activity syndecan...

factor in blood vessels. Specifically, erlizumab targets CD18 and an LFA-1 integrin. Erlizumab was meant to stop lymphocyte movement into inflamed tissue,...

JM (October 1999). "Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine...

intracellular domain of approximately 70 kDa, which interacts with beta4-integrin, plectin, and BP230 and is necessary for the stable attachment of hemidesmosomes...

by coupling T-cell antigen receptor stimulation to the activation of integrins. The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral...

decreased adhesion and disruption of integrin function. Accordingly, Bves disruption results in impaired integrin recycling, phenocopying the result seen...

68Ga-Trivehexin, a tracer targeting the tumor cell surface protein αvβ6-integrin. 68Ga-Trivehexin demonstrated high uptake in a brain metastasis of tonsil...

differentiation neuron remodeling actin cytoskeleton reorganization regulation of integrin activation podosome assembly cell adhesion Rac protein signal transduction...

plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins. GRCh38: Ensembl release 89: ENSG00000177076...

metric cellular matrix is bound by transmembrane proteins, including the β1-integrin, to the cytoskeleton via the membrane skeleton. The axolemma is a phospholipid...

bundle assembly negative regulation of cell-cell adhesion mediated by integrin Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry Species...

adhesion. This process will then be mediated by integrins, such as β1 (α2β1, α5β1) and β3 (αIIbβ3) integrins. In addition, platelets are activated, they will...

m-band protein skelemin and beta-integrin subunits. Colocalization of a skelemin-like protein with beta1- and beta3-integrins in non-muscle cells". The Journal...

biology. While there he completed a research thesis in a genetics lab on integrin-mediated cell-cell adhesion pathways in the Drosophila melanogaster model...

data Gene ontology Molecular function insulin-like growth factor binding integrin binding heparin binding Cellular component extracellular region extracellular...

disease. Recent evidence suggests that some forms of HIV also use the large integrin a4b7 receptor to facilitate increased binding efficiency in mucosal tissues...

to lipopolysaccharide negative regulation of cell adhesion mediated by integrin negative regulation of endopeptidase activity positive regulation of transcription...

Burridge K (1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". J. Cell Biol. 111 (2): 721–9. doi:10.1083/jcb.111.2...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

endocytosis and exocytosis. They are composed of specific proteins, such as integrins and cadherins. They can be visualized by electron microscopy or fluorescence...

several types of protein, including fibronectin, laminin, fibulin, and integrin. A single collagen molecule, tropocollagen, is used to make up larger collagen...

2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative...

regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism". American Journal of Physiology. Cell Physiology....

namely integrin-α7β1 and α-dystroglycan. In LAMA2-CMD the laminin alpha2 deficiency results in malfunctioning or down regulation of integrin-α7β1 and...

downstream signalling cascade enhances the expression of RANKL-dependent integrin αvβ3, DC-STAMP, calcitonin receptors, and NFATc1 (which is part of the...

vedolizumab Entyvio ulcerative colitis, Crohn's disease monoclonal antibody α4β7 integrin blocker ixekizumab Taltz plaque psoriasis, psoriatic arthritis, ankylosing...

Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene. Hemidesmosomes are structures...

negative regulation of peptidyl-serine phosphorylation positive regulation of integrin-mediated signaling pathway protein secretion by platelet negative regulation...

leadership 2022 Basic Richard O. Hynes For discoveries concerning the integrins – key mediators of cell–matrix and cell–cell adhesion in physiology and...

expression or changes the function of certain adhesion molecules (α4/β7 integrin) in lymphocytes, so they accumulate in the lymphatic tissue (lymphatic...

of animals. The genome of the strain "Amastigomonas sp." presents the integrin-mediated adhesion machinery, the primary cell-matrix adhesion mechanism...

which is an orally active and selective antagonist of the α4β1 and α4β7 integrin receptors. It reduces trafficking of lymphocytes into the central nervous...

CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection". J. Virol. 82 (1):...

protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion". J. Biol. Chem. 279 (8): 6824–33. doi:10.1074/jbc.M307978200...

epidermotropic Langerhans cell histiocytosis that expresses CD1 and specific beta 2-integrin molecules". Am. J. Pathol. 148 (5): 1699–708. PMC 1861573. PMID 8623937...

(telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18". European Journal of Immunology. 30 (3): 810–818. doi:10...

make up the costamere in striated muscle cells. The other complex is the integrin-vinculin-talin complex. The dystrophin-associated protein complex includes...

gels. Multisubunit transmembrane receptors called integrins are used to bind to the ECM. Integrins bind extracellularly to fibronectin, laminin, or other...

structures called podosomes. Attachment to the bone matrix is facilitated by integrin receptors, such as αvβ3, via the specific amino acid motif Arg-Gly-Asp...

the viral glycoprotein spikes to host cell receptors, particularly β3 integrins. Decay acceleration factors, complement receptors, and, for New World...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

Zhang Y, et al. (2001). "A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading". J. Cell Biol...

various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular...

members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation...

both casein and other highly acidic proteins and members of the small integrin-binding ligand, the N-linked glycoproteins (SIBLING) family at the target...

2001). "Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation"...

beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter". J. Biol. Chem. 279 (26): 26948–58. doi:10.1074/jbc.M310634200...

bind PI3K directly. In addition, the Gα subunit activates Src-dependent integrin signaling which can activate PI3K. Activated PI3K catalyses the addition...

Afsaneh; Rostamizadeh, Kobra; Fathi, Mojtaba (March 2025). "Dual silencing of integrin αvβ3 receptor and insulin-like growth factor 1 receptor using mPEG-PCL/DDAB...

cysteine-rich domains are implicated in cell adhesion and interaction with integrins, while the transmembrane domain anchors the protein in the membrane. The...

Gene ontology Molecular function signal transducer activity lipid binding integrin binding sphingosine-1-phosphate receptor activity G protein-coupled receptor...

platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling". The Journal of Biological Chemistry. 272...

it also drives cancer and fibrosis. In particular, Parsons focuses on integrins, and their behaviour in the extracellular matrix. By comparing "normal"...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

binding extracellular matrix structural constituent fibrinogen binding integrin binding protein C-terminus binding protein binding identical protein binding...

(July 2005). "L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas". International Journal of Cancer. 115...

head-and-neck and pancreatic cancer in humans by targeting the "Cancer Integrin" αvβ6 with Ga-68-Trivehexin". European Journal of Nuclear Medicine and...

transmembrane receptor protein tyrosine phosphatase activity hydrolase activity integrin binding Cellular component integral component of membrane membrane integral...

CM, White MM, Wilkinson DA, Jennings LK (1999). "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets...

gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding...

epithelial cell migration by binding to avB3-integrins. However studies have shown that avB3-integrins are not critically essential for angiogenesis...

a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil...

(Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which...

D-isomer feG are known to alter leukocyte adhesion involving actions on αMβ2 integrin, and inhibit the binding of CD16b (FCyRIII) antibody to human neutrophils...

the surrounding tissue matrix. ANGPTL4 secreted from tumors can bind to integrins, activating downstream signaling and leading to the production of superoxide...

involved in cell-cell adhesion and cell-matrix adhesion (e.g. cadherin and integrin, respectively). Other genes, however, seem to be exclusively found in animals...

homeostasis MAPK cascade Fc-epsilon receptor signaling pathway immune response integrin-mediated signaling pathway mast cell degranulation inflammatory response...

as "hardware sensor errors" derived from membrane friction— caveolae, integrins, cadherins, growth factor receptors, myosin motors, cytoskeletal filaments...

Khanim FL, Jeanes A, Talma S, Hughes S, et al. (July 2006). "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes". The...

extracellular matrix (ECM). ECM remodeling initiates signaling impulses through integrin and leads to the release of local growth factors. The cascade starts with...

S2CID 19892941. Yonekawa K, Harlan JM (February 2005). "Targeting leukocyte integrins in human diseases". Journal of Leukocyte Biology. 77 (2): 129–40. doi:10...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

2001). "Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine...

region membrane plasma membrane Biological process negative regulation of integrin biosynthetic process negative regulation of cell migration negative regulation...

adhesion fibrillar center cell junction Biological process regulation of integrin activation cell adhesion cell junction assembly regulation of cell shape...

KeeSoo; Son, Seog-ho; et al. (March 15, 2017). "Binding of galectin-1 to integrin β1 potentiates drug resistance by promoting survivin expression in breast...

Map Smith JW. Allostery and proteolysis: two novel modes of regulating integrin function. Matrix Biol. 1997 Oct;16(4):173-8. Review. Burnham Institute...

Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides". Journal of Nuclear Medicine. 51 (3): 433–40...

important regulator of lymphocyte adhesion, acting upstream of Rap1 in the integrin activation pathway. GRCh38: Ensembl release 89: ENSG00000095370 – Ensembl...

roles of integrin, Notch, Wnt and receptor tyrosine kinase signalling in regulating their behavior. She identified the first marker, integrin extracellular...

System, Ubiquitin-like Proteins (Brenda Schulman) Molecular Medicine: Integrin, Adhesion Signalling, Mouse Genetics (Reinhard Fässler) Molecular Structural...

pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin"...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

factor binding vascular endothelial growth factor binding kinase activity integrin binding protein binding ATP binding transmembrane receptor protein tyrosine...

Vestweber D (Apr 1994). "The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly". The Journal of Biological...

cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. Also, syndecans bind to FGFs and bring them to...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

has been found to bind to ICAP1alpha (integrin cytoplasmic domain associated protein alpha), a beta1 integrin associated protein. A particular mutation...

In the ocular form, the antigen identified is the β4 subuniti of α6β4 integrin. One other notable form is the anti-epillegrin form of MMP, where the target...

fibrils in vitro, while fibronectin, fibronectin-binding, collagen-binding integrins and collagen V are essential for collagen I forming and collagen XI for...

Insulin Insulin-like growth factor Integral membrane protein Integrase Integrin Intein Interferon Interleukin Inulin Ionomycin Ionone Iron–sulfur cluster...

calcification: Possible role of Gaucher cells, bone matrix proteins and integrins." Canadian Journal of Cardiology (1999; 15(2): 211-216). D. Hanania and...

desmosomes have been noted as have abnormal distribution of alpha2beta1 integrin adhesion molecules. Congenital chloride diarrhoea Congenital sodium diarrhoea...

enables it to utilize the normal cell biology of integrin and FAK for cancer growth. Normal integrin is a cell surface receptor that interacts with the...

transporter activity negative regulation of cell-cell adhesion mediated by integrin negative regulation of heterotypic cell-cell adhesion negative regulation...

anions, and changes in the avidity of cell adhesion molecules called integrins. Chemokines and their receptors play a crucial role in cancer metastasis...

encoding protein Integrator complex subunit 6 ITGBL1: encoding protein Integrin subunit beta like 1 GPALPP1: encoding protein KIAA1704 L1TD1P1: encoding...

Campbell AM, Nannizzi L, Charo IF (1991). "Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri ". The Journal of Biological...

types of cell adhesion proteins or cell adhesion molecules (CAMs) such as integrins, cadherins, NCAMs, or selectins Some types of receptor proteins Glycophorin...

it to integrin signaling. Separately, Minegishi et al. cloned the gene encoding a protein hyperphosphorylated following ligation of β1-integrins in T cells...

Green, CD; Koteliansky, V; Giancotti, FG (August 2002). "Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important...

"The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid...

non-collagenous proteins known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, are components of the extracellular...

PMID 16203771. Peng L, Jin G, Wang L, et al. (2006). "Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3"...

rare reports of cardiac failure.[citation needed] Natalizumab is an anti-integrin monoclonal antibody that has shown utility as induction and maintenance...

to mean: a part of the T-cell receptor, the fibrinogen alpha chain, the integrin alpha chain, Hemoglobin, alpha 1 It should be distinguished from the term...

RMS. The study of this one particular integrin was conducted in mice. By using antibodies to bind to α6β1 integrin subunits, found on the neuroblasts, the...

role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric...

a signaling cascade that results in activation of platelet integrins. Activated integrins mediate tight binding of platelets to the extracellular matrix...

is a receptor for Ljungan virus on the outer membrane of a cell called integrin αvβ6. The viral Protein RGD is what binds the virus to the cell it is trying...

isolated the cellular receptors that bind that sequence, now known as integrins. The RGD discovery has led to the development of drugs for vascular thrombosis...

induces the chemotactic migration of T cells and the cell adhesion caused by integrin activation. In contrast, the soluble CCL21 is not involved in the induction...

Medicine. Li J, Mayne R, Wu C (Feb 2000). "A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation". J Cell...

Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration". Dev. Cell. 5 (2): 257–71...

2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. doi:10.1074/jbc.M402084200...

enzymes in the gut, is an enterotoxin, which acts on uninfected cells via integrin receptors, which in turn cause and increase in intracellular calcium ion...

family member 5". Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs...

Service (irs.gov). 2014. "EU financial services – digital perspectives". Integrin. 8 July 2024. Retrieved 4 December 2025. "NY DFS Releases Proposed Bitlicense...

suggested to be integrins. Thy1 is one of the known ligands of beta 3 integrins. Interaction of thy1 expressed on maturing axons with beta 3 integrins expressed...

linked to the basement membrane via specialised glycoproteins called integrins. Humans are born with a set number of heart muscle cells, or cardiomyocytes...

multifunctional protein. TSP-1 has multiple receptors, among which CD36, CD47 and integrins are of particular note. TSP-1 is antiangiogenic, inhibiting the proliferation...

cytoskeleton cytosol Flemming body Biological process negative regulation of integrin activation cerebral cortex development negative regulation of apoptotic...

dissociate into amoeboid single cells following the down-regulation of integrins. CMTs contrast with epithelial–mesenchymal transitions (EMT) which occur...

phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation". Mol. Biol...

Weitzman S, Jones JC (1999). "A Cell Signal Pathway Involving Laminin-5, α3β1 Integrin, and Mitogen-activated Protein Kinase Can Regulate Epithelial Cell Proliferation"...

peptides oftentimes mimic natural ligand sequences (e.g RGD peptides binding integrins). These biosensors, which provide great selectivity while preserving structural...

least 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts...

(November 2003). "Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration"...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

(luteinizing hormone and follicle-stimulating hormone) glycoprotein IIb/IIIa, an integrin found on platelets that is required for normal platelet aggregation and...

"Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium". Dev Biol. 287 (2): 336–45. doi:10.1016/j.ydbio.2005...

1997). "Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to...

(Nitric oxide receptor) cGMP Regulation of cGMP Gated channels, Kinases Integrins Fibronectins, other extracellular matrix proteins Nonreceptor tyrosine...

University of Ghent. His research interest was about Drosophila melanogaster integrins and a Caenorhabditis elegans UNC gene (uncoordinated phenotype). In 1997...

cells. The Janda laboratory has also identified a scFv specific for the integrin α3β1 that is internalized by human pancreatic cancer cells; subsequent...

regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11211–11216. Bibcode:1998PNAS...

Varner JA (Feb 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis". The Journal of...

negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein–Barr virus results...

angiogenesis, and disease by orchestrating changes in matrix degradation, integrins, and components of the ECM. HoxA5 is implicated in atherosclerosis. HoxD3...

fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion...

cell types, such as activated platelets and melanomas, is a result of integrin binding mediated through the RYD sequence in streptavidin. Monovalent vs...

which is necessary for Tr1 cells antigen specificity. CD49b belongs to the integrin family and is a receptor for many (extracellular) matrix and non-matrix...

protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate...

activity, MMP14 interacts with cell surface molecules (such as CD44 and integrins) to modulate cell signaling and behavior. Studies in knockout mice have...

This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin β7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase...

cerebral cortex. Next to GPR56, the α3β1 integrin is also involved in pial BM maintenance. Study from Itga3 (α3 integrin)/Gpr56 double knockout mice showed...

protein-containing receptors, typically G-protein coupled receptors, or an integrin on the host cell's surface. The S subunit then recruits a second, "F" subunit...

plasma membrane Biological process regulation of cell adhesion mediated by integrin ephrin receptor signaling pathway aortic valve morphogenesis cell-cell...

Haslett C, Sethi T (September 2007). "Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras". The Journal of Biological Chemistry. 282...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

epithelial tube angiogenesis signal transduction positive regulation of integrin activation negative regulation of Rho protein signal transduction negative...

which is in turn regulated by cooperative signalling by β3-containing integrin complexes and the membrane-bound protein uPAR. DOCK180 is a Rac-specific...

differentiation of NIH3T3, MC3T3-E1, and human mesenchymal stem cells via the integrin/MAPK signaling pathway". J. Biol. Chem. 279 (51): 53323–30. doi:10.1074/jbc...

lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions...

adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3". The Journal of Biological Chemistry. 284 (42): 28616–28623...

contains a canonical papain-like domain, and mSpeB2 has an additional human integrin binding domain. All superantigenic streptococcal pyrogenic exotoxins contain...

manners. Through interactions with specific cellular receptors such as integrins, the basement membrane collagen IV networks not only provide structural...

small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3". Blood. 107 (7): 2728–35. doi:10.1182/blood-2005-07-3023...

cotransporter; Gardos Channel. Cell adhesion ICAM-4 – interacts with integrins; BCAM – a glycoprotein that defines the Lutheran blood group and also...

crest cells to escape. Additionally, neural crest cells begin expressing integrins that associate with extracellular matrix proteins, including collagen...

circulating tumor cells leave the bloodstream and invade new tissues. Integrins help the cells attach to their new environment. Cancer cells then form...

implicated in cancer development. For example, concurrent targeting of Integrin β3 and IGF-1R genes in breast cancer has demonstrated significant downregulation...

Whittaker CA, Hynes RO (2003). "Distribution and Evolution of von Willebrand/Integrin A Domains: Widely Dispersed Domains with Roles in Cell Adhesion and Elsewhere"...

endothelial cells migrate in tandem, using adhesion molecules called integrins. These sprouts then form loops to become a full-fledged vessel lumen as...

IL-17 Signaling Pathway Map TAB2TAB3 (Zhang et al., 2024) Integrin Signaling Pathway KEGG Integrin Signaling Pathway Map MTORPXN (Zhang et al., 2024) JAK-STAT...

of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein". PLOS Pathogens. 11...

Modulation of CD151 Lateral Interactions, Subcellular Distribution, and Integrin-dependent Cell Morphology". Molecular Biology of the cell. "$45M in private...

(2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling"...

Mennati A, Rostamizadeh K, Fathi M (1 March 2025). "Dual silencing of integrin αvβ3 receptor and insulin-like growth factor 1 receptor using mPEG-PCL/DDAB...

pathway via JAK-STAT negative regulation of cell adhesion mediated by integrin xenobiotic metabolic process cellular response to hydrogen peroxide membrane...

cell invasion of the central nervous system, via proteins called beta 2 integrins, and reduced overall survival. As described above on the example of dendritic...

Billard M, Boucheix C, Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry...

proliferation, differentiation, and survival. It functions by direct binding to integrin receptors, as well as other receptors such as NOTCH1 and fibulin 1c (FBLN1)...

lipid rafts in non-coated vesicles. EV1 uses α2β1-integrin as cellular receptor. Multiple integrin heterodimers can bind to the adjacent sites of the...

oxide synthase Prostacyclin Endothelium-derived relaxing factor Endothelin Integrin network Endothelial shear stress Marchio P, Guerra-Ojeda S, Mauricio MD...

Manganese-containing polypeptides are the diphtheria toxin, lectins, and integrins. The oxygen-evolving complex (OEC), containing four atoms of manganese...

sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling...

Alwin A.; Adolfs, Youri (2011-12-15). "Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development...

the role of ECM components in gene expression by their interaction with integrin-based focal adhesion pathways was reported. In 1998 scientists first isolated...

PMID 6407756. Eliceiri, B. P.; Klemke, R.; Stromblad, S.; Cheresh, D. A. (1998). "Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity...

MS, Kiesel L, Ibrahim SA, Götte M (May 2013). "Syndecan-1 modulates β-integrin-dependent and interleukin-6-dependent functions in breast cancer cell adhesion...

vessel endothelium) and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into tissues...

viral glycoprotein spikes to host cell receptors, particularly β1 and β3 integrins. Decay acceleration factors and complement receptors have also been proposed...

interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains". FEBS Lett. 445 (2–3): 351–5. doi:10.1016/S0014-5793(99)00151-9...

Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63–Integrin β1 Interaction". Hypertension. 69 (6). Dallas, Tex.: 1092–1103. doi:10...

1993). "Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal...

fibrinogen, and other adhesive proteins, alongside the discovery of integrins, which are the cell surface receptors that recognize the RGD sequence...

Cellular component cytoplasm integral component of membrane alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex membrane tertiary granule integral...

filaments. In hemidesmosomes plectin has been shown to interact with the integrin β4 subunits of the hemidesmosome plaque and function in a clamp-like manner...

adhesions, cell-cell adhesions, and cytoskeletal reorganization. By binding integrin α5β1 on endothelia cells it inhibits the signaling pathways of Ras and...

Chen Z, Sulaiman K, Feinberg MW, Ballantyne CM, et al. (August 2004). "Integrin engagement regulates monocyte differentiation through the forkhead transcription...

Claudia Fischbach (7 August 2023). "Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer...

Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C (2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly...

through CXCR4 (CD184) the receptor for CXC Chemokines (e.g., SDF1) and α4β1 integrins. Hematopoietic stem cells (HSC) cannot be easily observed directly, and...

higher ECM stiffness phenotype commonly seen in tumors due to enhanced integrin signaling could flatten the cell and nucleus, once again causing higher...

including mechanobiology, cytoskeletal biology, extracellular matrix biology, integrin signaling, tumor angiogenesis, tissue engineering, nanobiotechnology, systems...

grabbing non-integrin). Coronaviruses bind to macrophages via the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN)...

"Adhesion of cultured human kidney mesangial cells to native entactin: role of integrin receptors". Cell Adhesion and Communication. 5 (3): 237–248. doi:10...

encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor...

(2004). "Binding of anthrax toxin to its receptor is similar to alpha integrin-ligand interactions". J. Biol. Chem. 278 (49): 49342–7. doi:10.1074/jbc...

with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in...

podosomes. In the ring complex, integrins and integrin-associated proteins serve to connect the cytoskeleton to cell surface integrins forming the outward protrusion...

reference expression data BioGPS n/a Gene ontology Molecular function integrin binding zinc ion binding peptidase activity metalloendopeptidase activity...

receptors on the extracellular matrix, which stimulate adhesion through integrins (heterodimer α2β1), and downstream signalling. GPVI is present as a complex...

by p53 class mediator negative regulation of cell adhesion mediated by integrin DNA damage response, signal transduction by p53 class mediator resulting...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. The RPSA gene encodes a multifunctional...

Woodside DG, et al. (2000). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676–81....

Chen M, Sinha M, Luxon BA, Bresnick AR, O'Connor KL (January 2009). "Integrin alpha6beta4 controls the expression of genes associated with cell motility...

PMID 10885563. Moresco EM, Donaldson S, Williamson A, Koleske AJ (June 2005). "Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases"...

help the APC and the Th cell adhere during Th cell activation, but the integrin protein LFA-1 on the T cell and ICAM on the APC are the primary molecules...

neural crest cells stop making N-CAM and N-cadherin, and start displaying integrin receptors, cells separate and migrate. During hematopoiesis, CD56 is the...

reference expression data Gene ontology Molecular function isomerase activity integrin binding protein binding procollagen-proline 4-dioxygenase activity protein...

he investigated how a platelet integrin disengages from its ligand and described an allosteric disulfide in the integrin that when cleaved by a vascular...

Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, et al. (June 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

Molecular function vinculin binding zinc ion binding metal ion binding integrin binding actin filament binding protein binding actin binding protein kinase...

"The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity"...

MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones...

intracellular contraction and concomitant alignment of the collagen fibers by integrin-mediated pulling on to the collagen bundles. Pericytes and renal mesangial...

1007/s11892-004-0055-z. PMID 15539010. S2CID 45122439. Sheppard D (September 2005). "Integrin-mediated activation of latent transforming growth factor beta". Cancer...

(2010). "Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38...

"Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation". PLOS ONE. 7 (12) e52209. Bibcode:2012PLoSO...

village in Tartus Governorate Talin (protein), the protein that connects integrin to the cytoskeleton Thaumatin, a flavoring Facundo Talín (born 1985), Argentine...

downstream signals have been shown to possibly interact with integrin signals, such as FAK. Integrin signaling will phosphorylate FAK, which can then decrease...

extracellular matrix disassembly regulation of cell-cell adhesion mediated by integrin locomotory exploration behavior endothelial cell migration positive regulation...

infects endothelial cells and macrophages. It enters cells by using β3-integrins as receptors. Virions are taken into a cell via an endosome. Once pH is...

adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading". J. Cell Biol. 149 (5): 1143–56. doi:10.1083/jcb...

mRNA binding iron ion binding unfolded protein binding zinc ion binding integrin binding DNA binding chaperone binding peptide binding androgen receptor...

develop anoikis resistance by several mechanisms, including changes in integrin and matrix signaling, metabolic deregulation, and stress responses of cancer...

and is likely involved in leukocyte transmigration, angiogenesis, and integrin activation. CD31 on endothelial cells binds to the CD38 receptor on natural...

growth factor expression, and subtype B which is associated with increased integrin expression. There is an increased expression of the gene C2orf27A shown...

system corresponds to a specific platelet glycoprotein. HPA‑1 resides on integrin β3 (GPIIb/IIIa). The HPA‑1a/1b polymorphism involves a leucine-to-proline...

infects endothelial cells and macrophages. It enters cells by using β3-integrins as receptors. Virions are taken into a cell via an endosome. Once pH is...

(November 2001). "Coexpressed nitric oxide synthase and apical beta(1) integrins influence tubule cell adhesion after cytokine-induced injury". Journal...