Name |
Brand name |
Type |
Source |
Target |
Approved |
Use
|
3F8 |
|
mab |
mouse |
GD2 ganglioside |
|
neuroblastoma
|
Abagovomab[1] |
|
mab |
mouse |
CA-125 (imitation) |
|
ovarian cancer
|
Abciximab[2] |
ReoPro |
Fab |
chimeric |
CD41 (integrin alpha-IIb) |
Y[3] |
platelet aggregation inhibitor
|
Abituzumab[4] |
|
mab |
humanized |
CD51 |
|
cancer
|
Abrezekimab[5] |
|
Fab |
humanized |
IL-13 |
|
|
Abrilumab[6] |
|
mab |
human |
integrin α4 β7 |
|
inflammatory bowel disease, ulcerative colitis, Crohn's disease
|
Actoxumab[6] |
|
mab |
human |
Clostridioides difficile |
|
Clostridioides difficile colitis
|
Adalimumab[7] |
Humira |
mab |
human |
TNF-α |
Y[8] |
rheumatoid arthritis, Crohn's disease, plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, hemolytic disease of the newborn
|
Adecatumumab[9] |
|
mab |
human |
EpCAM |
|
prostate and breast cancer
|
Aducanumab[10] |
Aduhelm |
mab |
human |
Amyloid beta |
Y[11] |
Alzheimer's disease
|
Afasevikumab[12] |
|
mab |
human |
IL-17A, IL-17F |
|
multiple sclerosis
|
Afelimomab[2] |
|
F(ab')2 |
mouse |
TNF-α |
|
sepsis
|
Alacizumab pegol[13] |
|
F(ab')2 |
humanized |
VEGFR2 |
|
cancer
|
Alemtuzumab[14] |
Lemtrada, Campath |
mab |
humanized |
CD52 |
Y |
multiple sclerosis
|
Alirocumab[15] |
Praluent |
mab |
human |
PCSK9 |
Y |
hypercholesterolemia
|
Altumomab pentetate |
Hybri-ceaker |
mab |
mouse |
Carcinoembryonic antigen (CEA) |
|
colorectal cancer (diagnosis)
|
Amatuximab[16] |
|
mab |
chimeric |
mesothelin |
|
cancer
|
Amivantamab |
Rybrevant |
BsAb |
human |
Epidermal growth factor receptor (EGFR), cMet |
Y |
non-small cell lung cancer
|
Anatumomab mafenatox[17] |
|
Fab |
mouse |
Tumor-associated glycoprotein 72 (TAG-72) |
|
non-small cell lung cancer
|
Andecaliximab[18] |
|
mab |
chimeric |
gelatinase B |
|
gastric cancer or gastroesophageal junction adenocarcinoma
|
Anetumab ravtansine[4] |
|
mab |
human |
mesothelin (MSLN) |
|
cancer
|
Anifrolumab[4] |
Saphnelo |
mab |
human |
IFN-α/β receptor |
Y[19] |
systemic lupus erythematosus
|
Ansuvimab |
Ebanga |
mab |
human |
Ebola virus glycoprotein |
Y |
treatment of Zaire ebolavirus (Ebola virus)
|
Anrukinzumab[13] (= IMA-638)[20] |
|
mab |
humanized |
IL-13 |
|
asthma
|
Apolizumab[21] |
|
mab |
humanized |
HLA-DR |
|
hematological cancers
|
Aprutumab ixadotin[22] |
|
mab |
human |
FGFR2 |
|
|
Arcitumomab[23] |
CEA-Scan |
Fab' |
mouse |
Carcinoembryonic antigen (CEA) |
|
gastrointestinal cancers (diagnosis)
|
Ascrinvacumab[12] |
|
mab |
human |
activin receptor-like kinase 1 |
|
cancer
|
Aselizumab[24] |
|
mab |
humanized |
L-selectin (CD62L) |
|
severely injured patients
|
Atezolizumab[25] |
Tecentriq |
mab |
humanized |
PD-L1 |
Y |
cancer
|
Atidortoxumab[26] |
|
mab |
human |
Staphylococcus aureus alpha toxin |
|
|
Atinumab[16] |
|
mab |
human |
RTN4 |
|
|
Atoltivimab |
|
mab |
human |
Ebola virus glycoprotein |
|
part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus)
|
Atoltivimab/maftivimab/odesivimab |
Inmazeb |
mab |
human |
|
Y |
treatment of Zaire ebolavirus (Ebola virus)
|
Atorolimumab[2] |
|
mab |
human |
Rhesus factor |
|
hemolytic disease of the newborn[citation needed]
|
Avelumab[12] |
Bavencio |
mab |
human |
PD-L1 |
Y |
cancer
|
Axatilimab[27] |
Niktimvo |
mab |
humanized |
CSF1R |
Y |
chronic graft-versus-host disease
|
Azintuxizumab vedotin[28] |
|
mab |
chimeric/ humanized |
CD319 |
|
cancer
|
Bamlanivimab[29] |
|
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Emergency Use Authorization (EUA) when used with etesevimab[30] |
COVID-19
|
Bapineuzumab[31] |
|
mab |
humanized |
β-amyloid |
|
Alzheimer's disease
|
Basiliximab[32] |
Simulect |
mab |
chimeric |
CD25 (α chain of IL-2 receptor) |
Y |
prevention of organ transplant rejections
|
Bavituximab[1] |
|
mab |
chimeric |
phosphatidylserine |
|
cancer, viral infections
|
BCD-100 |
|
|
human |
PD-1 |
|
melanoma
|
Bebtelovimab[33] |
|
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Emergency Use Authorization (EUA)[34] |
COVID-19
|
Bectumomab[32] |
LymphoScan |
Fab' |
mouse |
CD22 |
|
non-Hodgkin's lymphoma (detection)
|
Bedinvetmab[35] |
Librela[36] |
mab |
veterinary |
nerve growth factor (NGF)[36] |
Y |
pain associated with osteoarthritis in dogs[36]
|
Begelomab[6] |
|
mab |
mouse |
DPP4 |
|
|
Belantamab mafodotin[5] |
Blenrep |
mab |
humanized |
B-cell maturation antigen (BCMA) |
Y (Withdrawn) |
relapsed or refractory multiple myeloma
|
Belimumab[37] |
Benlysta |
mab |
human |
B-cell activating factor (BAFF) |
Y |
systemic lupus erythematosus without renal or CNS involvement
|
Bemarituzumab[26] |
|
mab |
humanized |
FGFR2 |
|
gastric cancer or gastroesophageal junction adenocarcinoma
|
Benralizumab[38] |
Fasenra |
mab |
humanized |
CD125 |
Y |
asthma
|
Berlimatoxumab[26] |
|
mab |
human |
Staphylococcus aureus bi-component leukocidin |
|
|
Bermekimab[32] |
Xilonix |
mab |
human |
IL-1α |
|
colorectal cancer
|
Bersanlimab[5] |
|
mab |
human |
ICAM-1 |
|
|
Bertilimumab[24] |
|
mab |
human |
CCL11 (eotaxin-1) |
|
severe allergic disorders
|
Besilesomab[39] |
Scintimun |
mab |
mouse |
Carcinoembryonic antigen (CEA)-related antigen |
|
inflammatory lesions and metastases (detection)
|
Bevacizumab[14] |
Avastin |
mab |
humanized |
VEGF-A |
Y |
metastatic cancer, retinopathy of prematurity
|
Bezlotoxumab[32] |
Zinplava |
mab |
human |
Clostridioides difficile |
Y |
Clostridioides difficile colitis
|
Biciromab[32] |
FibriScint |
Fab' |
mouse |
fibrin II, beta chain |
|
thromboembolism (diagnosis)
|
Bimagrumab[40] |
|
mab |
human |
ACVR2B |
|
myostatin inhibitor
|
Bimekizumab[10] |
Bimzelx |
mab |
humanized |
IL-17A, IL-17F, IL-17AF |
Y |
psoriasis
|
Birtamimab |
|
mab |
chimeric |
serum amyloid A protein |
|
amyloidosis
|
Bivatuzumab[32] |
|
mab |
humanized |
CD44 v6 |
|
squamous cell carcinoma
|
Bleselumab[12] |
|
mab |
human |
CD40 |
|
organ transplant rejection
|
Blinatumomab[32] |
Blincyto |
BiTE |
mouse |
CD19 |
Y |
pre-B Acute lymphoblastic leukemia (ALL) (CD19+)
|
Blontuvetmab[41] |
Blontress |
mab |
veterinary |
CD20 |
|
|
Blosozumab[42] |
|
mab |
humanized |
SOST |
|
osteoporosis
|
Bococizumab[32] |
|
mab |
humanized |
PCSK9 |
|
dyslipidemia
|
Brazikumab[18] |
|
mab |
human |
IL-23 |
|
Crohn's disease
|
Brentuximab vedotin[32] |
Adcentris |
mab |
chimeric |
CD30 (TNFRSF8) |
Y |
Hodgkin's lymphoma, anaplastic large-cell lymphoma
|
Briakinumab[32] |
|
mab |
human |
IL-12, IL-23 |
|
psoriasis, rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis
|
Brodalumab[42] |
Siliq |
mab |
human |
IL-17 |
Y |
Plaque psoriasis
|
Brolucizumab[25] |
Beovu |
scFv |
humanized |
vascular endothelial growth factor A (VEGFA) |
Y |
wet age-related macular degeneration
|
Brontictuzumab[6] |
|
mab |
humanized |
Notch 1 |
|
cancer
|
Burosumab[18] |
Crysvita |
mab |
human |
FGF 23 |
Y |
X-linked hypophosphatemia
|
Cabiralizumab[41] |
|
mab |
humanized |
CSF1R |
|
metastatic pancreatic cancer
|
Camidanlumab tesirine[26] |
|
mab |
human |
CD25 (α chain of IL-2 receptor) |
|
B-cell Hodgkin's lymphoma, non-Hodgkin lymphoma, acute lymphoblastic leukemia, acute myeloid leukemia
|
Camrelizumab[22] |
|
mab |
humanized |
PD-1 |
|
hepatocellular carcinoma
|
Canakinumab[43] |
Ilaris |
mab |
human |
IL-1 |
Y |
cryopyrin-associated periodic syndrome, Yao's Syndrome, Adult Onset Still's Disease
|
Cantuzumab mertansine[42] |
|
mab |
humanized |
CanAg (a glycoform of MUC1) |
|
colorectal cancer etc.
|
Cantuzumab ravtansine[42] |
|
mab |
humanized |
CanAg (a glycoform of MUC1) |
|
cancers
|
Caplacizumab[44] |
Cablivi |
sdAb |
humanized |
VWF |
Y |
thrombotic thrombocytopenic purpura, thrombosis
|
Casirivimab[29] |
|
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Yes when used with imdevimab[45][46] |
COVID-19
|
Capromab[32] |
Prostascint |
mab |
mouse |
Glutamate carboxypeptidase II |
Y |
prostate cancer (detection)
|
Carlumab[16] |
|
mab |
human |
MCP-1 |
|
oncology/immune indications
|
Carotuximab[41] |
|
mab |
chimeric |
endoglin |
|
angiosarcoma
|
Catumaxomab[31] |
Removab |
3funct |
rat/mouse hybrid |
EpCAM, CD3 |
Y |
ovarian cancer, malignant ascites, gastric cancer
|
cBR96-doxorubicin immunoconjugate |
|
mab |
humanized |
Lewis-Y antigen |
|
cancer
|
Cedelizumab[47] |
|
mab |
humanized |
CD4 |
|
prevention of organ transplant rejections, treatment of autoimmune diseases
|
Cemiplimab[32] |
Libtayo |
mab |
human |
PD-1 |
Y |
cutaneous squamous cell carcinoma
|
Cergutuzumab amunaleukin[12] |
|
mab |
humanized |
IL-2 |
|
cancer
|
Certolizumab pegol[43] |
Cimzia |
Fab' |
humanized |
TNF-α |
Y |
Crohn's disease, rheumatoid arthritis, axial spondyloarthritis, psoriasis arthritis
|
Cetrelimab[5] |
|
mab |
human |
PD-1 |
|
cancer
|
Cetuximab[32] |
Erbitux |
mab |
chimeric |
Epidermal growth factor receptor (EGFR) |
Y |
metastatic colorectal cancer and head and neck cancer
|
Cibisatamab[5] |
|
mab |
humanized |
CEACAM5 |
|
cancer
|
Cilgavimab[29] |
|
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Emergency Use Authorization (EUA) when used with tixagevimab[48] |
COVID-19
|
Cirmtuzumab[32] |
|
|
humanized |
ROR1 |
|
chronic lymphocytic leukemia
|
Citatuzumab bogatox[49] |
|
Fab |
humanized |
EpCAM |
|
ovarian cancer and other solid tumors
|
Cixutumumab[32] |
|
mab |
human |
IGF-1 receptor (CD221) |
|
solid tumors
|
Clazakizumab[50] |
|
mab |
humanized |
IL-6 |
|
rheumatoid arthritis
|
Clenoliximab[32] |
|
mab |
chimeric |
CD4 |
|
rheumatoid arthritis
|
Clivatuzumab tetraxetan[32] |
hPAM4-Cide |
mab |
humanized |
MUC1 |
|
pancreatic cancer
|
Codrituzumab[4] |
|
mab |
humanized |
glypican 3 |
|
cancer
|
Cofetuzumab pelidotin[26] |
|
mab |
humanized |
PTK7 |
|
cancer
|
Coltuximab ravtansine[4] |
|
mab |
chimeric |
CD19 |
|
cancer
|
Conatumumab[49] |
|
mab |
human |
TRAIL-R2 |
|
cancer
|
Concizumab[51] |
Alhemo |
mab |
humanized |
tissue factor pathway inhibitor (TFPI) |
Y |
bleeding with hemophilia
|
Cosfroviximab[28] |
ZMapp |
mab |
chimeric |
ebolavirus glycoprotein |
|
Ebola virus
|
Cosibelimab[27] |
Unloxcyt[52] |
mab |
human |
Programmed death ligand-1 (PD-L1) |
Y |
cutaneous squamous cell carcinoma
|
Crenezumab[32] |
|
mab |
humanized |
β-amyloid (1-40 and 1-42) |
|
Alzheimer's disease
|
Crizanlizumab[22] |
Adakveo |
mab |
humanized |
selectin P |
Y |
sickle-cell disease
|
Crotedumab[41] |
|
mab |
human |
glucagon receptor (GCGR) |
|
diabetes
|
Crovalimab[53] |
Piasky |
mab |
humanized |
C5 |
Y |
paroxysmal nocturnal hemoglobinuria
|
CR6261 |
|
mab |
human |
Hemagglutinin (influenza) |
|
infectious disease/influenza A
|
Cusatuzumab[5] |
|
mab |
humanized |
CD70 |
|
cancer
|
Dacetuzumab[13] |
|
mab |
humanized |
CD40 |
|
hematologic cancers
|
Daclizumab[54] |
Zenapax |
mab |
humanized |
CD25 (α chain of IL-2 receptor) |
Y |
prevention of organ transplant rejections, multiple sclerosis
|
Dalotuzumab |
|
mab |
humanized |
IGF-1 receptor (CD221) |
|
cancer etc.
|
Dapirolizumab pegol[55] |
|
mab |
humanized |
CD154 (CD40L) |
|
|
Daratumumab[56] |
Darzalex |
mab |
human |
CD38 |
Y[57] |
multiple myeloma
|
Dectrekumab[25] |
|
mab |
human |
IL-13 |
|
|
Demcizumab |
|
mab |
humanized |
DLL4 |
|
cancer
|
Denintuzumab mafodotin[6] |
|
mab |
humanized |
CD19 |
|
cancer
|
Denosumab[58] |
Prolia |
mab |
human |
RANKL |
Y |
osteoporosis, bone metastases etc.
|
Depatuxizumab mafodotin[22] |
|
mab |
chimeric/ humanized |
EGFR |
|
glioblastoma
|
Derlotuximab biotin |
|
mab |
chimeric |
histone complex |
|
recurrent glioblastoma multiforme
|
Detumomab |
|
mab |
mouse |
B-lymphoma cell |
|
lymphoma
|
Dezamizumab[22] |
|
mab |
humanized |
serum amyloid P component |
|
|
Dinutuximab |
Unituxin |
mab |
chimeric |
GD2 ganglioside |
Y |
neuroblastoma
|
Dinutuximab beta |
Qarziba |
mab |
chimeric |
GD2 ganglioside |
Y |
neuroblastoma
|
Diridavumab |
|
mab |
human |
Hemagglutinin (influenza) |
|
influenza A
|
Divozilimab[29] |
Ivlizi |
mab |
humanized |
CD20 |
Y (Russia)[59] |
multiple sclerosis
|
Domagrozumab[41] |
|
mab |
humanized |
GDF-8 |
|
Duchenne muscular dystrophy
|
Donanemab[35] |
Kisunla[60] |
mab |
humanized |
Amyloid beta |
Y[60] |
Alzheimer's disease
|
Dorlimomab aritox[61] |
|
F(ab')2 |
mouse |
|
|
|
Dostarlimab[62] |
Jemperli |
mab |
humanized |
PCDP1 |
Y |
endometrial cancer
|
Drozitumab |
|
mab |
human |
DR5 |
|
cancer etc.
|
DS-8201 |
|
|
humanized |
HER2 |
|
gastric or gastroesophageal junction adenocarcinoma
|
Duligotuzumab[15] |
|
mab |
humanized |
ERBB3 (HER3) |
|
testicular cancer
|
Dupilumab[40] |
Dupixent |
mab |
human |
IL-4Rα |
Y |
atopic dermatitis, asthma, nasal polyps
|
Durvalumab[25] |
Imfinzi |
mab |
human |
PD-L1 |
Y |
cancer
|
Dusigitumab |
|
mab |
human |
IGF-2 |
|
B-cell malignancies
|
Duvortuxizumab[28] |
|
scFv |
chimeric/ humanized |
CD19, CD3E |
|
cancer
|
Ecromeximab[21] |
|
mab |
chimeric |
GD3 ganglioside |
|
malignant melanoma
|
Eculizumab[21] |
Soliris |
mab |
humanized |
C5 |
Y |
paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome
|
Edobacomab |
|
mab |
mouse |
endotoxin |
|
sepsis caused by Gram-negative bacteria
|
Edrecolomab |
Panorex |
mab |
mouse |
EpCAM |
|
colorectal carcinoma
|
Efalizumab[7] |
Raptiva |
mab |
humanized |
LFA-1 (CD11a) |
|
psoriasis (blocks T-cell migration)
|
Efungumab[1] |
Mycograb |
scFv |
human |
Hsp90 |
|
invasive Candida infection
|
Eldelumab[4] |
|
mab |
human |
CXCL10 (IP-10) |
|
Crohn's disease, ulcerative colitis
|
Elezanumab[22] |
|
mab |
human |
repulsive guidance molecule A (RGMA) |
|
spinal cord injury and multiple sclerosis
|
Elgemtumab[25] |
|
mab |
human |
ERBB3 (HER3) |
|
cancer
|
Elotuzumab |
Empliciti |
mab |
humanized |
SLAMF7 |
Y |
multiple myeloma
|
Elsilimomab |
|
mab |
mouse |
IL-6 |
|
|
Emactuzumab[6] |
|
mab |
humanized |
CSF1R |
|
cancer
|
Emapalumab[22] |
Gamifant |
mab |
human |
IFN-γ |
Y |
hemophagocytic lymphohistiocytosis
|
Emibetuzumab |
|
mab |
humanized |
HGFR |
|
cancer
|
Emicizumab[12] |
Hemlibra |
BsAb |
humanized |
activated F9, F10 |
Y |
haemophilia A
|
Enapotamab vedotin[5] |
|
mab |
human |
AXL |
|
cancer
|
Enavatuzumab |
|
mab |
humanized |
TWEAK receptor |
|
cancer etc.
|
Enfortumab vedotin[4] |
Padcev |
mab |
human |
nectin-4 |
Y[63] |
urothelial cancer
|
Enlimomab pegol[64] |
|
mab |
mouse |
ICAM-1 (CD54) |
|
|
Enoblituzumab[22] |
|
mab |
humanized |
CD276 |
|
cancer
|
Enokizumab |
|
mab |
humanized |
IL-9 |
|
asthma
|
Enoticumab[15] |
|
mab |
human |
DLL4 |
|
|
Ensituximab |
|
mab |
chimeric |
MUC5AC |
|
cancer
|
Epcoritamab |
Epkinly[27][65] |
BiTE |
humanized |
CD3, CD20 |
Y |
diffuse large B-cell lymphoma
|
Epitumomab cituxetan[66] |
|
mab |
mouse |
episialin |
|
|
Epratuzumab |
|
mab |
humanized |
CD22 |
|
cancer, systemic lupus erythematosus (SLE)
|
Eptinezumab[22] |
Vyepti |
mab |
humanized |
calcitonin gene-related peptide |
Y[67] |
migraine
|
Erenumab[22] |
Aimovig |
mab |
human |
calcitonin gene-related peptide receptor (CGRP) |
Y |
migraine
|
Erlizumab[68] |
|
F(ab')2 |
humanized |
ITGB2 (CD18) |
|
heart attack, stroke, traumatic shock
|
Ertumaxomab[31] |
Rexomun |
3funct |
rat/mouse hybrid |
HER2/neu, CD3 |
Y |
breast cancer etc.
|
Etaracizumab |
Abegrin |
mab |
humanized |
integrin αvβ3 |
Y |
melanoma, prostate cancer, ovarian cancer etc.
|
Etesevimab[29] |
|
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Emergency Use Authorization (EUA) when used with bamlanivimab[30] |
COVID-19
|
Etigilimab[5] |
|
mab |
humanized |
TIGIT |
|
|
Etrolizumab[16] |
|
mab |
humanized |
integrin β7 |
|
inflammatory bowel disease
|
Evinacumab |
Evkeeza |
mab |
human |
angiopoietin 3 |
Y |
dyslipidemia
|
Evolocumab[40] |
Repatha |
mab |
human |
PCSK9 |
Y |
hypercholesterolemia
|
Exbivirumab[69] |
|
mab |
human |
hepatitis B surface antigen |
|
hepatitis B
|
Fanolesomab[17] |
NeutroSpec |
mab |
mouse |
CD15 |
|
appendicitis (diagnosis)
|
Faralimomab |
|
mab |
mouse |
IFN receptor |
|
|
Faricimab[5] |
Vabysmo |
mab |
humanized |
VEGF-A and Ang-2 |
Y |
angiogenesis, ocular vascular diseases
|
Farletuzumab |
|
mab |
humanized |
folate receptor 1 |
|
ovarian cancer
|
Fasinumab |
|
mab |
human |
nerve growth factor (NGF) |
|
acute sciatic pain
|
FBTA05[70][71] |
Lymphomun |
3funct |
rat/mouse hybrid |
CD20 |
|
chronic lymphocytic leukaemia
|
Felvizumab |
|
mab |
humanized |
respiratory syncytial virus |
|
respiratory syncytial virus infection
|
Fezakinumab[72][73] |
|
mab |
human |
IL-22 |
|
rheumatoid arthritis, psoriasis
|
Fibatuzumab[74] |
|
mab |
humanized |
ephrin receptor A3 |
|
|
Ficlatuzumab |
|
mab |
humanized |
Hepatocyte growth factor (HGF) |
|
cancer etc.
|
Figitumumab |
|
mab |
human |
IGF-1 receptor (CD221) |
|
adrenocortical carcinoma, non-small cell lung carcinoma etc.
|
Firivumab[6] |
|
mab |
human |
Hemagglutinin (influenza) |
|
|
Flanvotumab[44] |
|
mab |
human |
TYRP1 (glycoprotein 75) |
|
melanoma
|
Fletikumab |
|
mab |
human |
IL-20 |
|
rheumatoid arthritis
|
Flotetuzumab[5] |
|
di-scFv |
humanized |
IL-3 receptor |
|
hematological malignancies
|
Fontolizumab[21] |
HuZAF |
mab |
humanized |
IFN-γ |
|
Crohn's disease etc.
|
Foralumab[75] |
|
mab |
human |
CD3E |
|
|
Foravirumab[49] |
|
mab |
human |
rabies virus glycoprotein |
|
rabies (prophylaxis)
|
Fremanezumab[22] |
Ajovy |
mab |
humanized |
calcitonin gene-related peptide alpha and beta |
Y |
migraine
|
Fresolimumab[56] |
|
mab |
human |
TGF-β |
|
idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, cancer
|
Frovocimab[62] |
|
mab |
humanized |
PCSK9 |
|
hypercholesterolemia
|
Frunevetmab[76] |
Solensia[77] |
mab |
veterinary |
nerve growth factor (NGF)[77] |
Y |
pain associated with osteoarthritis in cats[77]
|
Fulranumab |
|
mab |
human |
nerve growth factor (NGF) |
|
pain
|
Futuximab[15] |
|
mab |
chimeric |
Epidermal growth factor receptor (EGFR) |
|
cancer
|
Galcanezumab[41] |
Emgality |
mab |
humanized |
calcitonin |
Y |
migraine
|
Galiximab |
|
mab |
chimeric |
CD80 |
|
B-cell lymphoma
|
Gancotamab |
|
scFv |
human |
HER2/neu |
|
cancer
|
Ganitumab |
|
mab |
human |
IGF-1 receptor (CD221) |
|
cancer
|
Gantenerumab[43] |
|
mab |
human |
β-amyloid (1-40 and 1-42) |
|
Alzheimer's disease
|
Garadacimab[35] |
|
mab |
human |
Coagulation factor XIIa |
|
hereditary angioedema
|
Gatipotuzumab[28] |
|
mab |
humanized |
MUC1 |
|
cancer
|
Gavilimomab[68] |
|
mab |
mouse |
CD147 (basigin) |
|
graft versus host disease
|
Gedivumab[28] |
|
mab |
human |
Hemagglutinin (influenza) |
|
|
Gemtuzumab ozogamicin[22] |
Mylotarg |
mab |
humanized |
CD33 |
Y |
acute myelogenous leukemia
|
Gevokizumab |
|
mab |
humanized |
IL-1β |
|
diabetes etc.
|
Gilvetmab[28] |
|
mab |
veterinary |
PCDC1 |
|
|
Gimsilumab[26] |
|
mab |
human |
CSF2 |
|
rheumatoid arthritis
|
Girentuximab[56] |
Rencarex |
mab |
chimeric |
carbonic anhydrase 9 (CA-IX) |
|
clear cell renal cell carcinoma[78]
|
Glembatumumab vedotin[38][79] |
|
mab |
human |
GPNMB |
|
melanoma, breast cancer
|
Glofitamab[27] |
Columvi[80] |
BsAb |
humanized |
CD20, CD3 |
Y[80] |
diffuse large B-cell lymphoma[80]
|
Golimumab[69] |
Simponi |
mab |
human |
TNF-α |
Y |
rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis
|
Gomiliximab |
|
mab |
chimeric |
CD23 (IgE receptor) |
|
allergic asthma
|
Gosuranemab |
|
mab |
humanized |
tau protein |
|
progressive supranuclear palsy
|
Guselkumab |
Tremfya |
mab |
human |
IL-23 |
Y |
psoriasis
|
Ianalumab[26] |
|
mab |
human |
BAFF-R |
|
autoimmune hepatitis
|
Ibalizumab[43] |
Trogarzo |
mab |
humanized |
CD4 |
Y |
HIV infection
|
Sintilimab |
|
|
human |
PD-1 |
|
squamous cell non-small cell lung cancer
|
Ibritumomab tiuxetan |
Zevalin |
mab |
mouse |
CD20 |
Y |
non-Hodgkin's lymphoma
|
Icrucumab |
|
mab |
human |
VEGFR-1 |
|
cancer etc.
|
Idarucizumab[4] |
Praxbind |
mab |
humanized |
dabigatran |
Y |
reversal of anticoagulant effects of dabigatran
|
Ifabotuzumab[22] |
|
mab |
humanized |
EPHA3 |
|
glioblastoma multiforme[81]
|
Igovomab |
Indimacis-125 |
F(ab')2 |
mouse |
CA-125 |
|
ovarian cancer (diagnosis)
|
Iladatuzumab vedotin[26] |
|
mab |
humanized |
CD79B |
|
cancer
|
Imalumab[6] |
|
mab |
human |
macrophage migration inhibitory factor (MIF) |
|
cancer
|
Imaprelimab[5] |
|
mab |
humanized |
melanoma cell adhesion molecule (MCAM) |
|
|
Imciromab |
Myoscint |
mab |
mouse |
cardiac myosin |
Y |
cardiac imaging
|
Imdevimab[29] |
|
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Yes when used with casirivimab[45][46] |
COVID-19
|
Imgatuzumab[15] |
|
mab |
humanized |
Epidermal growth factor receptor (EGFR) |
|
cancer
|
Inclacumab[44] |
|
mab |
human |
selectin P |
|
cardiovascular disease
|
Indatuximab ravtansine[42] |
|
mab |
chimeric |
SDC1 |
|
cancer
|
Indusatumab vedotin[25] |
|
mab |
human |
GUCY2C |
|
cancer
|
Inebilizumab[12] |
Uplizna |
mab |
humanized |
CD19 |
Y[82] |
cancer, systemic sclerosis, multiple sclerosis
|
Infliximab |
Remicade |
mab |
chimeric |
TNF-α |
Y |
rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis, Crohn's disease, ulcerative colitis
|
Intetumumab[83][84] |
|
mab |
human |
CD51 |
|
solid tumors (prostate cancer, melanoma)
|
Inolimomab |
|
mab |
mouse |
CD25 (α chain of IL-2 receptor) |
|
graft versus host disease
|
Inotuzumab ozogamicin[39] |
Besponsa |
mab |
humanized |
CD22 |
Y |
Acute lymphoblastic leukemia (ALL)
|
Ipilimumab[58] |
Yervoy |
mab |
human |
CD152 |
Y |
melanoma
|
Iomab-B |
|
|
mouse |
CD45 |
|
ablation of bone marrow
|
Iratumumab[58] |
|
mab |
human |
CD30 (TNFRSF8) |
|
Hodgkin's lymphoma
|
Isatuximab |
Sarclisa |
mab |
chimeric |
CD38 |
Y |
multiple myeloma
|
Iscalimab[5] |
|
mab |
human |
CD40 |
|
|
Istiratumab[26] |
|
mab |
human |
IGF-1 receptor (CD221) |
|
advanced solid tumors
|
Itolizumab[75] |
Alzumab |
mab |
humanized |
CD6 |
Y |
psoriasis
|
Ixekizumab |
Taltz |
mab |
humanized |
IL-17A |
Y |
autoimmune diseases
|
KappaMAB |
|
mab |
mouse |
Kappa Myeloma Antigen (KMA) |
|
multiple myeloma
|
Keliximab |
|
mab |
chimeric |
CD4 |
|
chronic asthma
|
Labetuzumab[7] |
CEA-Cide |
mab |
humanized |
Carcinoembryonic antigen (CEA) |
|
colorectal cancer
|
Lacnotuzumab[28] |
|
mab |
humanized |
CSF1, macrophage colony stimulating factor (MCSF) |
|
cancer
|
Ladiratuzumab vedotin[26] |
|
mab |
humanized |
LIV-1 |
|
cancer
|
Lampalizumab[15] |
|
Fab |
humanized |
Complement factor D (CFD) |
|
geographic atrophy secondary to age-related macular degeneration
|
Lanadelumab[41] |
Takhzyro |
mab |
human |
kallikrein |
Y |
angioedema
|
Landogrozumab[12] |
|
mab |
humanized |
GDF-8 |
|
muscle wasting disorders
|
Laprituximab emtansine[41] |
|
mab |
chimeric |
epidermal growth factor receptor (EGFR) |
|
|
Larcaviximab[28] |
|
mab |
chimeric |
ebolavirus glycoprotein |
|
Ebola virus
|
Lebrikizumab |
|
mab |
humanized |
IL-13 |
|
asthma
|
Lecanemab[85] |
Leqembi |
mab |
humanized |
β-amyloid |
Y[86] |
Alzheimer's disease
|
Lemalesomab[68] |
|
mab |
mouse |
NCA-90 (granulocyte antigen) |
|
diagnostic agent
|
Lendalizumab[41] |
|
mab |
humanized |
C5 |
|
|
Lenvervimab[5] |
|
mab |
humanized |
hepatitis B surfage antigen |
|
hepatitis B
|
Lenzilumab[6] |
|
mab |
human |
CSF2 |
|
chronic myelomonocytic leukemia and juvenile myelomonocytic leukemia
|
Lerdelimumab[17] |
|
mab |
human |
TGF-β2 |
|
reduction of scarring after glaucoma surgery
|
Leronlimab[5] |
|
mab |
humanized |
CCR5 |
|
breast cancer, HIV
|
Lesofavumab[28] |
|
mab |
human |
Hemagglutinin (influenza) |
|
|
Letolizumab[28] |
|
scFv |
humanized |
tumor necrosis factor related activation protein (TRAP) |
|
inflammatory diseases
|
Lexatumumab[1] |
|
mab |
human |
TRAIL-R2 |
|
cancer
|
Libivirumab[69] |
|
mab |
human |
hepatitis B surface antigen |
|
hepatitis B
|
Lifastuzumab vedotin |
|
mab |
humanized |
phosphate-sodium co-transporter |
|
cancer
|
Ligelizumab[15] |
|
mab |
humanized |
IGHE |
|
severe asthma, chronic spontaneous urticaria
|
Loncastuximab tesirine[87][74] |
Zynlonta |
mab |
chimeric |
CD19 |
Y |
relapsed or refractory large B-cell lymphoma
|
Losatuxizumab vedotin[28] |
|
mab |
chimeric/ humanized |
epidermal growth receptor factor (EGRF), ERBB1 HER1 |
|
cancer
|
Lilotomab satetraxetan[25] |
|
mab |
mouse |
CD37 |
|
cancer
|
Lintuzumab |
|
mab |
humanized |
CD33 |
|
cancer
|
Lirilumab[15] |
|
mab |
human |
KIR2D |
|
solid and hematological cancers
|
Lodelcizumab[40] |
|
mab |
humanized |
PCSK9 |
|
hypercholesterolemia
|
Lokivetmab[25] |
Cytopoint[88] |
mab |
veterinary |
Canis lupus familiaris IL31 |
Y |
clinical signs of atopic dermatitis in dogs[88]
|
Lorvotuzumab mertansine |
|
mab |
humanized |
CD56 |
|
cancer
|
Lucatumumab[13] |
|
mab |
human |
CD40 |
|
multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's lymphoma
|
Lulizumab pegol[6] |
|
mab |
humanized |
CD28 |
|
autoimmune diseases
|
Lumiliximab[9] |
|
mab |
chimeric |
CD23 (IgE receptor) |
|
chronic lymphocytic leukemia
|
Lumretuzumab[6] |
|
mab |
humanized |
ERBB3 (HER3) |
|
cancer
|
Lupartumab[22] |
|
mab |
human |
|
|
|
Lupartumab amadotin[22] |
|
mab |
human |
LYPD3 |
|
|
Lutikizumab[22] |
|
mab |
humanized |
IL-1α |
|
|
Maftivimab |
|
mab |
human |
|
|
part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus)
|
Mapatumumab[31] |
|
mab |
human |
TRAIL-R1 |
|
cancer
|
Margetuximab |
Margenza[89] |
mab |
humanized |
HER2 |
Y |
breast cancer
|
Marstacimab |
Hympavzi[90][91] |
mab |
human |
tissue factor pathway inhibitor (TFPI) |
Y |
bleeding with hemophilia
|
Maslimomab |
|
|
mouse |
T-cell receptor |
|
|
Mavrilimumab[38] |
|
mab |
human |
GMCSF receptor α-chain |
|
rheumatoid arthritis
|
Matuzumab[24] |
|
mab |
humanized |
Epidermal growth factor receptor (EGFR) |
|
colorectal, lung and stomach cancer
|
Mepolizumab[47] |
Bosatria |
mab |
humanized |
IL-5 |
Y |
asthma and white blood cell diseases
|
Metelimumab[24] |
|
mab |
human |
TGF-β1 |
|
systemic scleroderma
|
Milatuzumab[13] |
|
mab |
humanized |
CD74 |
|
multiple myeloma and other hematological malignancies
|
Minretumomab |
|
mab |
mouse |
TAG-72 |
|
tumor detection (and therapy?)
|
Mirikizumab[87] |
Omvoh |
mab |
humanized |
IL-23 |
Y |
ulcerative colitis
|
Mirvetuximab soravtansine[12] |
Elahere |
mab |
chimeric |
folate receptor alpha |
Y[92] |
ovarian cancer
|
Mitumomab |
|
mab |
mouse |
GD3 ganglioside |
|
small cell lung carcinoma
|
Modotuximab |
|
mab |
chimeric |
EGFR extracellular domain III |
|
cancer
|
Mogamulizumab[16] |
Poteligeo |
mab |
humanized |
CCR4 |
Y |
adult T-cell leukemia/lymphoma
|
Monalizumab[12] |
|
mab |
humanized |
NKG2A |
|
rheumatoid arthritis, gynecologic malignancies, and other cancers
|
Morolimumab[93] |
|
mab |
human |
Rhesus factor |
|
|
Mosunetuzumab[87] |
Lunsumio |
BiTE |
humanized |
CD3E, MS4A1, CD20 |
Y[94] |
follicular lymphoma
|
Motavizumab[1] |
Numax |
mab |
humanized |
respiratory syncytial virus |
|
respiratory syncytial virus (prevention)
|
Moxetumomab pasudotox |
Lumoxiti |
mab |
mouse |
CD22 |
Y |
hairy cell leukemia
|
Muromonab-CD3[95][96] |
Orthoclone OKT3 |
mab |
mouse |
CD3 |
|
prevention of organ transplant rejections
|
Nacolomab tafenatox |
|
Fab |
mouse |
C242 antigen |
|
colorectal cancer
|
Namilumab[16] |
|
mab |
human |
CSF2 |
|
|
Naptumomab estafenatox[97] |
|
Fab |
mouse |
5T4 |
|
non-small cell lung carcinoma, renal cell carcinoma
|
Naratuximab emtansine[41] |
|
mab |
chimeric |
CD37 |
|
|
Narnatumab |
|
mab |
human |
MST1R (aka RON) |
|
cancer
|
Natalizumab[93] |
Tysabri |
mab |
humanized |
integrin α4 |
Y |
multiple sclerosis, Crohn's disease
|
Navicixizumab[41] |
|
mab |
chimeric/ humanized |
DLL4 and VEGFA |
|
cancer
|
Navivumab[12] |
|
mab |
human |
Hemagglutinin (influenza) |
|
|
Naxitamab |
Danyelza |
|
humanized |
c-Met |
Y |
high-risk neuroblastoma and refractory osteomedullary disease
|
Nebacumab |
|
mab |
human |
endotoxin |
|
sepsis
|
Necitumumab[98] |
Portrazza |
mab |
human |
Epidermal growth factor receptor (EGFR) |
Y |
non-small cell lung carcinoma
|
Nemolizumab[25] |
|
mab |
humanized |
IL-31 receptor A |
|
eczema[99]
|
NEOD001 |
|
|
humanized |
amyloid |
|
primary systemic amyloidosis
|
Nerelimomab |
|
mab |
mouse |
TNF-α |
|
|
Nesvacumab |
|
mab |
human |
angiopoietin 2 |
|
cancer
|
Netakimab[5] |
Efleira |
mab |
humanized |
IL-17A |
Y (Russia)[100] |
plaque psoriasis, psoriatic arthritis, ankylosing spondylitis
|
Nimotuzumab[58][101] |
BioMab-EGFR, Theracim, Theraloc |
mab |
humanized |
epidermal growth factor receptor (EGFR) |
Y |
squamous cell carcinoma, head and neck cancer, nasopharyngeal cancer, glioma
|
Nirsevimab |
|
mab |
human |
RSV fusion glycoprotein |
|
respiratory syncytial virus
|
Nivolumab[6] |
Opdivo |
mab |
human |
PD-1 |
Y |
cancer
|
Nofetumomab merpentan |
Verluma |
Fab |
mouse |
|
|
cancer (diagnosis)
|
Obiltoxaximab |
Anthim |
mab |
chimeric |
Bacillus anthracis anthrax |
Y |
Bacillus anthracis spores
|
Obinutuzumab |
Gazyva |
mab |
humanized |
CD20 |
Y |
chronic lymphatic leukemia
|
Ocaratuzumab |
|
mab |
humanized |
CD20 |
|
cancer
|
Ocrelizumab[102] |
Ocrevus |
mab |
humanized |
CD20 |
Y |
multiple sclerosis
|
Odesivimab |
|
mab |
human |
|
|
part of Atoltivimab/maftivimab/odesivimab for treatment of Zaire ebolavirus (Ebola virus)
|
Odulimomab |
|
mab |
mouse |
LFA-1 (CD11a) |
|
prevention of organ transplant rejections, immunological diseases
|
Ofatumumab[31] |
Arzerra, Kesimpta[103] |
mab |
human |
CD20 |
Y |
chronic lymphocytic leukemia, multiple sclerosis[103]
|
Olaratumab |
Lartruvo |
mab |
human |
PDGFRA |
Y |
cancer
|
Oleclumab[28] |
|
mab |
human |
5'-nucleotidase |
|
pancreatic and colorectal cancer
|
Olendalizumab[28] |
|
mab |
humanized |
complement C5a |
|
systemic lupus erythematosus, lupus nephritis, acute graft-versus-hose disease
|
Olokizumab[75] |
|
mab |
humanized |
IL-6 |
|
rheumatoid arthritis
|
Omalizumab[68] |
Xolair |
mab |
humanized |
IgE Fc region |
Y |
allergic asthma, chronic spontaneous urticaria
|
Omburtamab[62] |
|
mab |
mouse |
CD276 |
|
cancer
|
OMS721 |
|
|
human |
MASP-2 |
|
atypical hemolytic uremic syndrome
|
Onartuzumab |
|
Fab |
humanized |
human scatter factor receptor kinase |
|
cancer
|
Ontuxizumab |
|
mab |
chimeric/ humanized |
TEM1 |
|
cancer
|
Onvatilimab[5] |
|
mab |
human |
VISTA (protein) (VSIR) |
|
|
Opicinumab |
|
mab |
human |
LINGO-1 |
|
multiple sclerosis
|
Oportuzumab monatox[98] |
Vicinium |
scFv |
humanized |
EpCAM |
|
bladder cancer
|
Oregovomab[17] |
OvaRex |
mab |
mouse |
CA-125 |
|
ovarian cancer
|
Orticumab[15] |
|
mab |
human |
oxLDL |
|
|
Otelixizumab[13] |
|
mab |
chimeric/ humanized |
CD3 |
|
diabetes mellitus type 1
|
Otilimab |
|
mab |
human |
GMCSF |
|
osteoarthritis, rheumatoid arthritis
|
Otlertuzumab |
|
mab |
humanized |
CD37 |
|
cancer
|
Oxelumab[42] |
|
mab |
human |
OX-40 |
|
asthma
|
Ozanezumab |
|
mab |
humanized |
NOGO-A |
|
ALS and multiple sclerosis
|
Ozoralizumab[42] |
|
mab |
humanized |
TNF-α |
|
inflammation
|
Pagibaximab[31] |
|
mab |
chimeric |
lipoteichoic acid |
|
sepsis (Staphylococcus)
|
Palivizumab |
Synagis, Abbosynagis |
mab |
humanized |
F protein of respiratory syncytial virus |
Y |
respiratory syncytial virus (prevention)
|
Pamrevlumab[12] |
|
mab |
human |
connective tissue growth factor (CTGF) |
|
idiopathic pulmonary fibrosis (IPF), pancreatic cancer
|
Panitumumab[69] |
Vectibix |
mab |
human |
epidermal growth factor receptor (EGFR) |
Y |
colorectal cancer
|
Pankomab |
|
mab |
humanized |
tumor specific glycosylation of MUC1 |
|
ovarian cancer
|
Panobacumab[98] |
|
mab |
human |
Pseudomonas aeruginosa |
|
Pseudomonas aeruginosa infection
|
Parsatuzumab[15] |
|
mab |
humanized |
EGFL7 |
|
cancer
|
Pascolizumab[21] |
|
mab |
humanized |
IL-4 |
|
asthma
|
Pasotuxizumab[6] |
|
mab |
chimeric/ humanized |
folate hydrolase |
|
cancer
|
Pateclizumab[42] |
|
mab |
humanized |
lymphotoxin alpha (LTA) |
|
TNF
|
Patritumab[44] |
|
mab |
human |
ERBB3 (HER3) |
|
cancer
|
PDR001 |
|
|
humanized |
PD-1 |
|
melanoma
|
Pembrolizumab[55] |
Keytruda |
mab |
humanized |
PD-1 |
Y[104] |
melanoma and other cancers
|
Pemivibart[105] |
Pemgarda |
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Emergency Use Authorization (EUA)[106] |
COVID-19
|
Pemtumomab |
Theragyn |
|
mouse |
MUC1 |
|
cancer
|
Perakizumab[15] |
|
mab |
humanized |
IL-17A |
|
arthritis
|
Pertuzumab |
Perjeta |
mab |
humanized |
HER2/neu |
Y |
cancer
|
Pexelizumab[17] |
|
scFv |
humanized |
C5 |
|
reduction of side effects of cardiac surgery
|
Pidilizumab[40] |
|
mab |
humanized |
PD-1 |
|
cancer and infectious diseases
|
Pinatuzumab vedotin[40] |
|
mab |
humanized |
CD22 |
|
cancer
|
Pintumomab |
|
mab |
mouse |
adenocarcinoma antigen |
|
adenocarcinoma (imaging)
|
Placulumab[15] |
|
mab |
human |
TNF |
|
pain and inflammatory diseases
|
Pozelimab[35] |
Veopoz |
mab |
human |
C5 |
Y |
CHAPLE disease
|
Prezalumab[41] |
|
mab |
human |
TNF |
|
|
Plozalizumab[12] |
|
mab |
humanized |
CCR2 |
|
diabetic nephropathy and arteriovenous graft patency
|
Pogalizumab[41] |
|
mab |
humanized |
tumor necrosis factor receptor (TNFR) superfamily member 4 |
|
|
Polatuzumab vedotin[51][4] |
Polivy |
mab |
humanized |
CD79B |
Y |
diffuse large B-cell lymphoma
|
Ponezumab |
|
mab |
humanized |
β-amyloid |
|
Alzheimer's disease
|
Porgaviximab[28] |
|
mab |
chimeric |
Zaire ebolavirus glycoprotein |
|
Ebola virus disease
|
Prasinezumab[26] |
|
mab |
humanized |
Alpha-synuclein |
|
Parkinson's disease
|
Prezalizumab[41] |
|
mab |
humanized |
inducible T-cell co-stimulatory ligand (ICOSL) |
|
|
Priliximab |
|
mab |
chimeric |
CD4 |
|
Crohn's disease, multiple sclerosis
|
Pritoxaximab[40] |
|
mab |
chimeric |
E. coli shiga toxin type-1 |
|
|
Pritumumab |
|
mab |
human |
vimentin |
|
brain cancer
|
PRO 140 |
|
|
humanized |
CCR5 |
|
HIV infection
|
Quilizumab[44] |
|
mab |
humanized |
IGHE |
|
asthma
|
Racotumomab[98] |
Vaxira |
mab |
mouse |
NGNA ganglioside |
Y |
non-small cell lung cancer
|
Radretumab[16] |
|
mab |
human |
fibronectin extra domain-B |
|
cancer
|
Rafivirumab[49] |
|
mab |
human |
rabies virus glycoprotein |
|
rabies (prophylaxis)
|
Ralpancizumab |
|
mab |
humanized |
PCSK9 |
|
dyslipidemia
|
Ramucirumab |
Cyramza |
mab |
human |
VEGFR2 |
Y |
solid tumors
|
Ranevetmab |
|
mab |
veterinary |
NGF |
|
osteoarthritis in dogs
|
Ranibizumab[9] |
Lucentis |
Fab |
humanized |
VEGF-A |
Y |
macular degeneration (wet form)
|
Raxibacumab[39] |
|
mab |
human |
anthrax toxin, protective antigen |
Y |
anthrax (prophylaxis and treatment)
|
Ravagalimab[5] |
|
mab |
humanized |
CD40 |
|
Crohn's disease
|
Ravulizumab[26] |
Ultomiris |
mab |
humanized |
C5 |
Y |
paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome
|
Refanezumab |
|
mab |
humanized |
myelin-associated glycoprotein |
|
recovery of motor function after stroke
|
Regavirumab |
|
mab |
human |
cytomegalovirus glycoprotein B |
|
cytomegalovirus infection
|
Regdanvimab[29] |
Regkirona[107] |
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Y[107] |
COVID-19
|
Relatlimab |
|
mab |
human |
LAG3 |
|
melanoma
|
Remtolumab[22] |
|
mab |
human |
IL-17A, TNF |
|
|
Reslizumab[7] |
Cinqair |
mab |
humanized |
IL-5 |
Y |
inflammations of the airways, skin and gastrointestinal tract
|
Retifanlimab[27] |
Zynyz[108] |
mab |
humanized |
PD-1 |
Y |
Merkel cell carcinoma
|
Rilotumumab |
|
mab |
human |
hepatocyte growth factor (HGF) |
|
solid tumors
|
Rinucumab |
|
mab |
human |
PDGFRB |
|
neovascular age-related macular degeneration
|
Risankizumab[12] |
Skyrizi |
mab |
humanized |
IL-23A |
Y |
Crohn's disease, psoriasis, psoriatic arthritis, and asthma
|
Rituximab |
MabThera, Rituxan |
mab |
chimeric |
CD20 |
Y[109] |
lymphomas, leukemias, some autoimmune disorders
|
Rivabazumab pegol[12] |
|
mab |
humanized |
Pseudomonas aeruginosa type III secretion system |
|
|
Robatumumab |
|
mab |
human |
IGF-1 receptor (CD221) |
|
cancer
|
Rmab |
RabiShield |
|
human |
rabies virus G glycoprotein |
Y |
post-exposure prophylaxis of rabies
|
Roledumab[75] |
|
mab |
human |
RHD (gene) (RHD) |
|
Rh disease
|
Romilkimab[5] |
|
mab |
chimeric/ humanized |
IL-13 |
|
|
Romosozumab[44] |
Evenity |
mab |
humanized |
sclerostin |
Y |
osteoporosis
|
Rontalizumab[56] |
|
mab |
humanized |
IFN-α |
|
systemic lupus erythematosus
|
Rosmantuzumab[22] |
|
mab |
humanized |
root plate-specific spondin 3 |
|
cancer
|
Rovalpituzumab tesirine[12] |
|
mab |
humanized |
DLL3 |
|
small cell lung cancer
|
Rovelizumab[47] |
LeukArrest |
mab |
humanized |
CD11, CD18 |
Y |
haemorrhagic shock etc.
|
Rozanolixizumab[22] |
Rystiggo |
mab |
chimeric/ humanized |
FCGRT |
Y[110]
|
myasthenia gravis
|
Ruplizumab[14] |
Antova |
mab |
humanized |
CD154 (CD40L) |
Y |
rheumatic diseases
|
SA237 |
|
|
humanized |
IL-6 receptor |
|
neuromyelitis optica and neuromyelitis optica spectrum disorders
|
Sacituzumab govitecan[22] |
Trodelvy |
mab |
humanized |
TROP-2 |
Y[111] |
triple-negative breast cancer
|
Samalizumab[42] |
|
mab |
humanized |
CD200 |
|
cancer
|
Samrotamab vedotin[5] |
|
mab |
chimeric/ humanized |
LRRC15 |
|
cancer
|
Sarilumab[44] |
Kevzara |
mab |
human |
IL-6 |
Y |
rheumatoid arthritis, ankylosing spondylitis
|
Satralizumab[76] |
Enspryng |
mab |
humanized |
IL-6 receptor |
Y |
neuromyelitis optica
|
Satumomab pendetide |
|
mab |
mouse |
TAG-72 |
|
cancer (diagnosis)
|
Secukinumab |
Cosentyx |
mab |
human |
IL-17A |
Y |
uveitis, rheumatoid arthritis psoriasis
|
Selicrelumab[28] |
|
mab |
human |
CD40 |
|
|
Seribantumab[40] |
|
mab |
human |
ERBB3 (HER3) |
|
cancer
|
Setoxaximab[40] |
|
mab |
chimeric |
E. coli shiga toxin type-2 |
|
|
Setrusumab[26] |
|
mab |
human |
sclerostin (SOST) |
|
|
Sevirumab |
|
|
human |
cytomegalovirus |
|
cytomegalovirus infection
|
Sibrotuzumab |
|
mab |
humanized |
FAP (gene) (FAP) |
|
cancer
|
SGN-CD19A |
|
mab |
humanized |
CD19 |
|
acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma
|
SHP647 |
|
|
human |
mucosal addressin cell adhesion molecule |
|
Crohn's disease
|
Sifalimumab[16] |
|
mab |
human |
IFN-α |
|
systemic lupus erythematosus (SLE), dermatomyositis, polymyositis
|
Siltuximab |
Sylvant |
mab |
chimeric |
IL-6 |
Y |
cancer
|
Simtuzumab[15] |
|
mab |
humanized |
LOXL2 |
|
fibrosis
|
Sipavibart[105] |
|
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
|
COVID-19
|
Siplizumab[21] |
|
mab |
humanized |
CD2 |
|
psoriasis, graft-versus-host disease (prevention)
|
Sirtratumab vedotin[26] |
|
mab |
human |
SLITRK6 |
|
cancer
|
Sirukumab |
|
mab |
human |
IL-6 |
|
rheumatoid arthritis
|
Sofituzumab vedotin |
|
mab |
humanized |
CA-125 |
|
ovarian cancer
|
Solanezumab[98][44] |
|
mab |
humanized |
β-amyloid |
|
Alzheimer's disease
|
Solitomab[44] |
|
BiTE |
mouse |
EpCAM |
|
gastrointestinal, lung, and other cancers
|
Sonepcizumab[112] |
|
|
humanized |
sphingosine-1-phosphate |
|
choroidal and retinal neovascularization
|
Sontuzumab[101] |
|
mab |
humanized |
episialin |
|
|
Sotrovimab[29] |
Xevudy |
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Y[113][114] |
COVID-19
|
Spartalizumab[26] |
|
mab |
humanized |
PD-1 |
|
melanoma
|
Spesolimab[53] |
Spevigo |
mab |
humanized |
Interleukin 36 receptor (IL1RL2/IL1RAP) |
Y |
generalized pustular psoriasis (GPP)
|
Stamulumab[102] |
|
mab |
human |
myostatin |
|
muscular dystrophy
|
Sugemalimab[85] |
|
mab |
human |
PD-1 |
|
non-small-cell lung cancer
|
Sulesomab |
LeukoScan |
Fab' |
mouse |
NCA-90 (granulocyte antigen) |
|
osteomyelitis (imaging)
|
Suptavumab[22] |
|
mab |
human |
RSVFR |
|
medically attended lower respiratory disease
|
Sutimlimab[5] |
Enjaymo |
mab |
chimeric/ humanized |
complement component 1s (C1s) |
Y |
cold agglutinin disease
|
Suvizumab[38] |
|
mab |
humanized |
HIV-1 |
|
viral infections
|
Suvratoxumab[28] |
|
mab |
human |
Staphylococcus aureus alpha toxin |
|
nosocomial pneumonia
|
Tabalumab[42] |
|
mab |
human |
B-cell activating factor (BAFF) |
|
B-cell cancers
|
Tacatuzumab tetraxetan |
AFP-Cide |
mab |
humanized |
alpha-fetoprotein |
|
cancer
|
Tadocizumab[101] |
|
Fab |
humanized |
integrin αIIbβ3 |
|
percutaneous coronary intervention
|
Tafasitamab[47] |
Monjuvi |
mab |
humanized (from mouse) |
CD19 |
Y |
relapsed or refractory diffuse large B-cell lymphoma
|
Talacotuzumab[26] |
|
mab |
humanized |
CD123 |
|
leukemia etc.
|
Talizumab[37] |
|
mab |
humanized |
IgE |
|
allergic reaction
|
Talquetamab |
Talvey |
BsAb |
humanized |
GPRC5D, CD3 |
Y |
relapsed or refractory multiple myeloma
|
Tamtuvetmab[41] |
Tactress |
mab |
veterinary |
CD52 |
|
|
Tanezumab[49] |
|
mab |
humanized |
nerve growth factor (NGF) |
|
pain
|
Taplitumomab paptox[68] |
|
mab |
mouse |
CD19 |
|
cancer[citation needed]
|
Tarextumab |
|
mab |
human |
Notch receptor |
|
cancer
|
Tarlatamab[29] |
Imdelltra[115] |
BsAb |
human |
DLL3, CD3[115] |
Y[115] |
small cell lung cancer[115]
|
Tavolimab |
|
mab |
chimeric/ humanized |
CD134 |
|
cancer
|
Teclistamab |
Tecvayli[35] |
BsAb |
human |
B-cell maturation antigen (BCMA), CD3 |
Y[116][117] |
relapsed or refractory multiple myeloma
|
Tefibazumab[39] |
Aurexis |
mab |
humanized |
clumping factor A |
|
Staphylococcus aureus infection
|
Telimomab aritox |
|
Fab |
mouse |
|
|
|
Telisotuzumab[22] |
|
mab |
humanized |
HGFR |
|
cancer
|
Telisotuzumab vedotin[22] |
|
mab |
humanized |
HGFR |
|
cancer
|
Tenatumomab[13] |
|
mab |
mouse |
tenascin C |
|
cancer
|
Teneliximab[21] |
|
mab |
chimeric |
CD40 |
|
autoimmune diseases and prevention of organ transplant rejection
|
Teplizumab[43] |
Tzield |
mab |
humanized |
CD3 |
Y |
diabetes mellitus type 1
|
Tepoditamab[5] |
|
mab |
human |
dendritic cell-associated lectin 2 |
|
cancer
|
Teprotumumab |
Tepezza |
mab |
human |
IGF-1 receptor (CD221) |
Y |
thyroid eye disease
|
Tesidolumab[25] |
|
mab |
human |
C5 |
|
|
Tetulomab |
|
mab |
humanized |
CD37 |
|
cancer[118]
|
Tezepelumab[12] |
Tezspire |
mab |
human |
thymic stromal lymphopoietin (TSLP) |
Y[119] |
asthma
|
TGN1412 |
|
|
humanized |
CD28 |
|
chronic lymphocytic leukemia, rheumatoid arthritis
|
Tibulizumab[26] |
|
mab |
humanized |
B-cell activating factor (BAFF) |
|
autoimmune disorders
|
Tildrakizumab |
Ilumya |
mab |
humanized |
IL-23 |
Y |
immunologically mediated inflammatory disorders
|
Tigatuzumab[13] |
|
mab |
humanized |
TRAIL-R2 |
|
cancer
|
Timigutuzumab[28] |
|
mab |
humanized |
HER2 |
|
cancer
|
Timolumab[41] |
|
mab |
human |
AOC3 |
|
|
tiragolumab[26] |
|
mab |
human |
|
|
|
Tiragotumab[26] |
|
mab |
human |
TIGIT |
|
cancer
|
Tislelizumab[26] |
|
mab |
humanized |
PCDC1, CD279 |
|
non-small cell lung cancer
|
Tisotumab vedotin[12] |
Tivdak |
mab |
human |
coagulation factor III |
Y |
relapsed or refractory cervical cancer[120][121]
|
Tixagevimab[29] |
|
mab |
human |
spike protein receptor binding domain (RBD) of SARS-CoV-2 |
Emergency Use Authorization (EUA) when used with cilgavimab[48] |
COVID-19
|
TNX-650 |
|
|
humanized |
IL-13 |
|
Hodgkin's lymphoma
|
Tocilizumab[9] |
Actemra, RoActemra |
mab |
humanized |
IL-6 receptor |
Y[122] |
rheumatoid arthritis
|
Tomuzotuximab[28] |
|
mab |
humanized |
Epidermal growth factor receptor (EGFR), HER1 |
|
cancer
|
Toralizumab[21] |
|
mab |
humanized |
CD154 (CD40L) |
|
rheumatoid arthritis, lupus nephritis etc.
|
Tosatoxumab[4] |
|
mab |
human |
Staphylococcus aureus |
|
|
Tositumomab |
Bexxar |
|
mouse |
CD20 |
Y |
follicular lymphoma
|
Tovetumab |
|
mab |
human |
PDGFRA |
|
cancer
|
Tralokinumab[123] |
Adtralza, Adbry[124] |
mab |
human |
IL-13 |
Y[124] |
atopic dermatitis
|
Trastuzumab |
Herceptin |
mab |
humanized |
HER2/neu |
Y |
breast cancer
|
Trastuzumab duocarmazine[22] |
Kadcyla |
mab |
humanized |
HER2/neu |
Y |
breast cancer
|
Trastuzumab emtansine |
Kadcyla |
mab |
humanized |
HER2/neu |
Y |
breast cancer
|
TRBS07[125] |
Ektomab |
3funct |
|
GD2 ganglioside |
|
melanoma
|
Tregalizumab[16] |
|
mab |
humanized |
CD4 |
|
|
Tremelimumab[126] |
Imjudo |
mab |
human |
CTLA-4 |
Y[127] |
hepatocellular carcinoma
|
Trevogrumab |
|
mab |
human |
growth differentiation factor 8 |
|
muscle atrophy due to orthopedic disuse and sarcopenia
|
Tucotuzumab celmoleukin[58][101] |
|
mab |
humanized |
EpCAM |
|
cancer
|
Tuvirumab |
|
|
human |
hepatitis B virus |
|
chronic hepatitis B
|
Ublituximab[128] |
Briumvi |
mab |
chimeric |
CD20 |
Y |
multiple sclerosis, chronic lymphocytic leukemia
|
Ulocuplumab[55] |
|
mab |
human |
CXCR4 (CD184) |
|
hematologic malignancies
|
Urelumab[16] |
|
mab |
human |
4-1BB (CD137) |
|
cancer etc.
|
Urtoxazumab[9] |
|
mab |
humanized |
Escherichia coli |
|
diarrhoea caused by E. coli
|
Ustekinumab[49] |
Stelara |
mab |
human |
IL-12, IL-23 |
Y |
multiple sclerosis, psoriasis, psoriatic arthritis
|
Utomilumab[22] |
|
mab |
human |
4-1BB (CD137) |
|
diffuse large B-cell lymphoma
|
Vadastuximab talirine[12] |
|
mab |
chimeric |
CD33 |
|
Acute myeloid leukemia
|
Vanalimab[5] |
|
mab |
humanized |
CD40 |
|
|
Vandortuzumab vedotin[25] |
|
mab |
humanized |
STEAP1 |
|
cancer
|
Vantictumab |
|
mab |
human |
Frizzled receptor |
|
cancer
|
Vanucizumab[6] |
|
mab |
humanized |
angiopoietin 2 |
|
cancer
|
Vapaliximab[21] |
|
mab |
chimeric |
AOC3 (VAP-1) |
|
|
Varisacumab[28] |
|
mab |
human |
VEGF-A |
|
angiogenesis
|
Varlilumab[6] |
|
mab |
human |
CD27 |
|
solid tumors and hematologic malignancies
|
Vatelizumab[42] |
|
mab |
humanized |
ITGA2 (CD49b) |
|
|
Vedolizumab[98] |
Entyvio |
mab |
humanized |
integrin α4 β7 |
Y[129] |
Crohn's disease, ulcerative colitis
|
Veltuzumab[13] |
|
mab |
humanized |
CD20 |
|
non-Hodgkin's lymphoma
|
Vepalimomab |
|
mab |
mouse |
AOC3 (VAP-1) |
|
inflammation
|
Vesencumab[16] |
|
mab |
human |
NRP1 |
|
solid malignancies
|
Vilobelimab[85] |
Gohibic |
mab |
chimeric |
C5a receptor (C5a) |
Emergency Use Authorization (EUA)[130] |
COVID-19
|
Visilizumab[68] |
Nuvion |
mab |
humanized |
CD3 |
|
Crohn's disease, ulcerative colitis
|
Vobarilizumab[41] |
|
scFv |
humanized |
IL-6 receptor |
|
inflammatory autoimmune diseases
|
Volociximab[31] |
|
mab |
chimeric |
integrin α5β1 |
|
solid tumors
|
Vonlerolizumab[28] |
|
mab |
humanized |
CD134 |
|
cancer
|
Vopratelimab[5] |
|
mab |
humanized |
CD278, aka ICOS |
|
|
Vorsetuzumab mafodotin |
|
mab |
humanized |
CD70 |
|
cancer
|
Votumumab |
HumaSPECT |
mab |
human |
tumor antigen CTAA16.88 |
|
colorectal tumors
|
Vunakizumab[22] |
|
mab |
humanized |
IL-17A |
|
|
Xentuzumab[41] |
|
mab |
humanized |
IGF-1, IGF-2 |
|
?
|
XMAB-5574 |
|
|
humanized |
CD19 |
|
diffuse large B-cell lymphoma
|
Zalutumumab[31] |
|
mab |
human |
Epidermal growth factor receptor (EGFR) |
|
squamous cell carcinoma of the head and neck
|
Zanidatamab[14] |
Ziihera[131] |
BsAb |
humanized |
HER2, HER2 |
Y |
biliary tract cancer[131]
|
Zanolimumab[39] |
|
mab |
human |
CD4 |
|
rheumatoid arthritis, psoriasis, T-cell lymphoma
|
Zatuximab[15] |
|
mab |
chimeric |
HER1 |
|
cancer
|
Zenocutuzumab[87] |
Bizengri[132] |
BsAb |
humanized |
HER2, ERBB3 (HER3) |
Y[132] |
cancer
|
Ziralimumab[68] |
|
mab |
human |
CD147 (basigin) |
|
|
Zolbetuximab[26] |
Vyloy[133] |
mab |
chimeric |
Claudin 18 Isoform 2 |
Y |
gastric cancer
|
Zolimomab aritox |
|
mab |
mouse |
CD5 |
|
systemic lupus erythematosus, graft-versus-host disease
|