Chen Lan-bo (Chinese: 陳良博) is a Taiwanese biotechnologist. He was a professor of pathology at Harvard Medical School between 1977 and 2004 and is the author of over 250 publications. He is also a member of Boston's Dana-Farber Cancer Institute[1] in the department of cancer and biology and a member of the Academia Sinica of Taiwan.
Chen did postdoctoral research work for one year supervised by James D. Watson, the Nobel laureate who co-discovered the DNA double helix structure.[4] He did research on the mitogenicity of thrombin and surface alterations on mouse splenocytes and also on intercellular LETS glycoprotein matrices.[5]
He is also a cell biologist making seminal findings in the multiple fields of molecular cell biology and cancer biology, including the discovery of rhodamine 123 for highly specific fluorescent localization of mitochondria in living cells, removal of carcinoma cells from contaminated bone marrow using the lipophilic cation, identification of human cancer line without any Intermediate filaments, and also on the development of the rare event detection system to detect lung cancer cells from Body fluids.[6][7][8]
In the early days of his career, he worked as a Senior Staff investigator at the Cold Spring Harbor Laboratories, before becoming a full and emeritus professor of pathology at the Harvard Medical School with laboratories at the Dana-Farber Cancer Institute.
Chen founded Synta Pharmaceuticals Corporation,[9][10] and in 2007, was invited to serve on the founding board of directors for Yu Chang Biologics Company, also known as TaiMed Biologics Company.[11][12] Chen was supportive of Tsai Ing-wen's 2012 presidential campaign after Tsai's involvement with TaiMed became a subject of investigation.[13][14] Chen described the Sunflower Student Movement of 2014 as "the mightiest movement Taiwan has seen in several decades" and said that "this student movement will kick-start the development of Taiwan’s biotech industry."[15] In January 2019, Chen signed a petition opposing the confirmation of Kuan Chung-ming as president of National Taiwan University.[16]
Awards and honors
Chen received the American Cancer Society Professor award,[17] and, in 1996, was elected as a member of the Academia Sinica.[18] He also served as a former board member at Madrigal Pharmaceuticals.[19]
Publications
Chen has published over 250 publications.[20] His contributions include the following:
Lan Bo Chen. "Mitochondrial Membrane Potential in Living Cells". Annual Review of Cell Biology.[21]
Lan Bo Chen, Andrew Murray, Rosalind A. Segal, Anne Bushnell, and Marcia L. Walsh. "Studies on intercellular LETS glycoprotein matrices". Journal of the cell.[22]
L B Chen, P H Gallimore, and J K McDougall. "Correlation between tumor induction and the large external transformation sensitive protein on the cell surface". Journal of PNAS.[23]
Lan Bo Chen. "Fluorescent Labeling of Mitochondria". Methods in cell biology.[24]
L.B.Chen, N.Maitland, P.H.Gallimore, and J.K.McDougall. "Detection of the large external transformation-sensitive protein on some epithelial cells". Journal of Experimental cell research.[25]
L.B.Chen, N.N.H.Teng, and J.M.Buchanan. "Mitogenicity of thrombin and surface alterations on mouse splenocytes". Journal of Experimental cell research.[26]
Lan Bo Chen and John M. Buchanan. "Plasminogen-Independent Fibrinolysis by Proteases Produced by Transformed Chick Embryo Fibroblasts". JSTOR.[27]
Lan Bo Chen, Keith Burridge, Andrew Murray, Marcia L. Walsh, Christine D. Copple, Anne Bushnell, James K. McDougall, and Phillip H. Gallimore. "Modulation of Cell Surface Glycocalyx: Studies on Large, External, Transformation-Sensitive Protein". Annals of the New York Academy of Sciences.[28]
Faith E. Davies, Ann M. Dring, Cheng Li, Andrew C. Rawstron, Masood A. Shammas, Sheila M. O'Connor, James A.L. Fenton, Teru Hideshima, Dharminder Chauhan, Isabella T. Tai, Elizabeth Robinson, Daniel Auclair, Karen Rees, David Gonzalez, A. John Ashcroft, Ranjit Dasgupta, Constantine Mitsiades, Nicholas Mitsiades, Lan B. Chen, Wing H. Wong, Nikhil C. Munshi, Gareth J. Morgan, and Kenneth C. Anderson. "Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis". Blood Journal.[29]
Xiuwei Yang, Christoph Claas, Stine-Kathrein Kraeft, Lan Bo Chen, Zemin Wang, Jordan A. Kreidberg, and Martin E. Hemler. "Palmitoylation of Tetraspanin Proteins: Modulation of CD151 Lateral Interactions, Subcellular Distribution, and Integrin-dependent Cell Morphology". Molecular Biology of the cell.[30]
^Chen, L. B.; Teng, N. N. H.; Buchanan, J. M. (1976-08-01). "Mitogenicity of thrombin and surface alterations on mouse splenocytes". Experimental Cell Research. 101 (1): 41–46. doi:10.1016/0014-4827(76)90409-2. ISSN0014-4827. PMID986310.
^Lampidis, Theodore J.; Salet, Christian; Moreno, Giuliana; Chen, Lan Bo (1984-09-01). "Effects of the mitochondrial probe rhodamine 123 and related analogs on the function and viability of pulsating myocardial cells in culture". Agents and Actions. 14 (5): 751–757. doi:10.1007/BF01978920. ISSN1420-908X. PMID6475672. S2CID1341638.
^Johnson, Lincoln V.; Summerhayes, Ian C.; Chen, Lan Bo (1982-01-01). "Decreased uptake and retention of rhodamine 123 by mitochondria in feline sarcoma virus-transformed mink cells". Cell. 28 (1): 7–14. doi:10.1016/0092-8674(82)90369-5. ISSN0092-8674. PMID6279315. S2CID38032526.
^Lampidis, T. J.; Bernal, S. D.; Summerhayes, I. C.; Chen, L. B. (February 1983). "Selective toxicity of rhodamine 123 in carcinoma cells in vitro". Cancer Research. 43 (2): 716–720. ISSN0008-5472. PMID6848187.
^Willis, Randall C. (September 2004). "Bad news for Beantown?". ACS Publications. Retrieved 1 January 2019.
^Chen, L. B.; Maitland, N.; Gallimore, P. H.; McDougall, J. K. (1977-04-01). "Detection of the large external transformation-sensitive protein on some epithelial cells". Experimental Cell Research. 106 (1): 39–46. doi:10.1016/0014-4827(77)90238-5. ISSN0014-4827. PMID852517.
^Chen, L. B.; Teng, N. N. H.; Buchanan, J. M. (1976-08-01). "Mitogenicity of thrombin and surface alterations on mouse splenocytes". Experimental Cell Research. 101 (1): 41–46. doi:10.1016/0014-4827(76)90409-2. ISSN0014-4827. PMID986310.
^Chen, Lan Bo; Burridge, Keith; Murray, Andrew; Walsh, Marcia L.; Copple, Christine D.; Bushnell, Anne; McDougall, James K.; Gallimore, Phillip H. (1978). "Modulation of Cell Surface Glycocalyx: Studies on Large, External, Transformation-Sensitive Protein*". Annals of the New York Academy of Sciences. 312 (1): 366–381. Bibcode:1978NYASA.312..366C. doi:10.1111/j.1749-6632.1978.tb16814.x. ISSN1749-6632. PMID386883. S2CID32711763.
