NBR1

NBR1
Identifiers
Aliases	NBR1, 1A1-3B, IAI3B, M17S2, MIG19, neighbor of BRCA1 gene 1, autophagy cargo receptor, NBR1 autophagy cargo receptor
External IDs	OMIM: 166945; MGI: 108498; GeneCards: NBR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WJ6, 2BKF, 2CP8, 2G4S, 2L8J, 2MGW, 2MJ5, 4OLE
Gene location (Human)
Chr.	Chromosome 17 (human)
End	43,211,689 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,472,777 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; amniotic fluid; ; parietal pleura; ; epithelium of nasopharynx; ; germinal epithelium; ; Epithelium of choroid plexus; ; internal globus pallidus; ; jejunal mucosa; ; palpebral conjunctiva; ; visceral pleura;
	Top expressed in
	ciliary body; ; retinal pigment epithelium; ; spermatid; ; seminiferous tubule; ; lacrimal gland; ; utricle; ; iris; ; pituitary gland; ; motor neuron; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; zinc ion binding; protein binding; mitogen-activated protein kinase binding; ubiquitin binding;
Cellular component	cytoplasm; M band; autophagosome; cytosol; late endosome; lysosome; extracellular exosome; membrane; cytoplasmic vesicle; phagophore assembly site; mitochondrion; nucleoplasm; nuclear body; intracellular membrane-bounded organelle;
Biological process	protein complex oligomerization; negative regulation of osteoblast differentiation; regulation of stress-activated MAPK cascade; regulation of bone mineralization; macroautophagy;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4077
	17966
	ENSG00000188554
	ENSMUSG00000017119
	Q14596
	P97432
	NM_001291571; NM_001291572; NM_005899; NM_031858; NM_031862
	NM_001252220; NM_001252222; NM_001252223; NM_008676
	NP_001278500; NP_001278501; NP_005890; NP_114068
	NP_001239149; NP_001239151; NP_001239152; NP_032702
	Wikidata
View/Edit Human	View/Edit Mouse

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.^[5]^[6]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.^[6] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.^[7]

Interactions

NBR1 has been shown to interact with FEZ1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188554 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017119 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, et al. (April 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Human Molecular Genetics. 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.
^ ^a ^b "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".
^ Kirkin V, McEwan DG, Novak I, Dikic I (May 2009). "A role for ubiquitin in selective autophagy". Molecular Cell. 34 (3): 259–269. doi:10.1016/j.molcel.2009.04.026. PMID 19450525.
^ Whitehouse C, Chambers J, Howe K, Cobourne M, Sharpe P, Solomon E (January 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". European Journal of Biochemistry. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.

Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, et al. (October 1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. Bibcode:1994Sci...266...66M. doi:10.1126/science.7545954. PMID 7545954.
Harshman K, Bell R, Rosenthal J, Katcher H, Miki Y, Swenson J, et al. (August 1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Human Molecular Genetics. 4 (8): 1259–1266. doi:10.1093/hmg/4.8.1259. PMID 7581362.
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–229. doi:10.1093/dnares/1.5.223. PMID 7584044.
Brown MA, Nicolai H, Xu CF, Griffiths BL, Jones KA, Solomon E, et al. (1995). "Regulation of BRCA1". Nature. 372 (6508): 733. Bibcode:1994Natur.372..733B. doi:10.1038/372733a0. PMID 7997258. S2CID 40825012.
Brown MA, Xu CF, Nicolai H, Griffiths B, Chambers JA, Black D, et al. (June 1996). "The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21". Oncogene. 12 (12): 2507–2513. PMID 8700509.
Dimitrov S, Brennerova M, Forejt J (January 2001). "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene. 262 (1–2): 89–98. doi:10.1016/S0378-1119(00)00549-7. PMID 11179671.
Whitehouse C, Chambers J, Howe K, Cobourne M, Sharpe P, Solomon E (January 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". European Journal of Biochemistry. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.
Wistow G, Bernstein SL, Ray S, Wyatt MK, Behal A, Touchman JW, et al. (June 2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Molecular Vision. 8: 185–195. PMID 12107412.
Lamark T, Perander M, Outzen H, Kristiansen K, Øvervatn A, Michaelsen E, et al. (September 2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins". The Journal of Biological Chemistry. 278 (36): 34568–34581. doi:10.1074/jbc.M303221200. PMID 12813044.
Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, et al. (June 2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science. 308 (5728): 1599–1603. Bibcode:2005Sci...308.1599L. CiteSeerX 10.1.1.383.9888. doi:10.1126/science.1110463. PMID 15802564. S2CID 2809403. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188554 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017119 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Campbell_1994-5] Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, et al. (April 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Human Molecular Genetics. 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.

[entrez-6] "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".

[7] Kirkin V, McEwan DG, Novak I, Dikic I (May 2009). "A role for ubiquitin in selective autophagy". Molecular Cell. 34 (3): 259–269. doi:10.1016/j.molcel.2009.04.026. PMID 19450525.

[Whitehouse_2002-8] Whitehouse C, Chambers J, Howe K, Cobourne M, Sharpe P, Solomon E (January 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". European Journal of Biochemistry. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.

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NBR1

Interactions

References

Further reading

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