GSG2

HASPIN
Identifiers
Aliases	HASPIN, GSG2, germ cell associated 2, haspin, histone H3 associated protein kinase
External IDs	OMIM: 609240; MGI: 1194498; GeneCards: HASPIN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VUW, 2WB8, 3DLZ, 3E7V, 3F2N, 3FMD, 3IQ7, 4OUC, 4QTC, 5HTC, 5HTB
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,726,699 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	73,029,120 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; secondary oocyte; ; ventricular zone; ; testicle; ; tibialis anterior muscle; ; ganglionic eminence; ; bone marrow cell; ; sperm; ; mucosa of ileum; ; stromal cell of endometrium;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; zygote; ; primary oocyte; ; secondary oocyte; ; tail of embryo; ; genital tubercle; ; primitive streak; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; histone kinase activity (H3-T3 specific); ATP binding; protein kinase activity;
Cellular component	cytoplasm; centrosome; chromosome; cytoskeleton; nucleus; spindle;
Biological process	intracellular signal transduction; phosphorylation; mitotic sister chromatid cohesion; protein localization to chromosome, centromeric region; cell cycle; protein phosphorylation; chromatin organization; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	83903
	14841
	ENSG00000177602
	ENSMUSG00000050107
	Q8TF76
	Q9Z0R0
	NM_031965
	NM_010353
	NP_114171
	NP_034483
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177602 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050107 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GSG2 germ cell associated 2 (haspin)".

Dai J, Sullivan BA, Higgins JM (2007). "Regulation of mitotic chromosome cohesion by Haspin and Aurora B." Dev. Cell. 11 (5): 741–50. doi:10.1016/j.devcel.2006.09.018. PMID 17084365.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Dai J, Sultan S, Taylor SS, Higgins JM (2005). "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment". Genes Dev. 19 (4): 472–88. doi:10.1101/gad.1267105. PMC 548948. PMID 15681610.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Higgins JM (2001). "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells". Gene. 267 (1): 55–69. doi:10.1016/S0378-1119(01)00387-0. PMID 11311556.
Tanaka H, Iguchi N, Nakamura Y, et al. (2001). "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase". Mol. Hum. Reprod. 7 (3): 211–8. doi:10.1093/molehr/7.3.211. PMID 11228240.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177602 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050107 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GSG2 germ cell associated 2 (haspin)".

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GSG2

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