2L9L
4240
17304
ENSG00000140545
ENSMUSG00000030605
Q08431
P21956
NM_001114614NM_001310319NM_001310320NM_001310321NM_005928
NM_001045489NM_008594
NP_001108086NP_001297248NP_001297249NP_001297250NP_005919
NP_001038954NP_032620
Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene.[5][6]
Mfge8 is a secreted protein found in vertebrates, including mammals as well as birds.
MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fibers in arteries.[7] An amyloid fragment of MFGE8 known as medin accumulates in the aorta with aging.[8] MFGE8 in the vasculature of adults can induce recovery from ischemia by facilitating angiogenesis.[9] It has been suggested that antagonizing MFGE8-induced angiogenesis could be a way of fighting cancer.[10]
MFGE8 contains a phosphatidylserine (PS) binding domain, as well as an arginine-glycine-aspartic acid motif, which enables the binding to integrins. MFGE8 binds PS, which is exposed on the surface of apoptotic cells.[11] Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.
This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.
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