2LSW
1601
13132
ENSG00000153071
ENSMUSG00000022150
P98082
P98078
NM_001343NM_001244871
NM_001008702NM_001037905NM_001102400NM_023118NM_001310446
NP_001231800NP_001334
NP_001008702NP_001032994NP_001095870NP_001297375NP_075607
Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.[5][6]
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).[7]
DAB2 has been shown to interact with:
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