Selenophos

Selenophos[1]
Names
Preferred IUPAC name
Se-[2-(Diethylamino)ethyl] O-ethyl ethylphosphonoselenoate
Other names
Seleno-VE[2]
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C10H24NO2PSe/c1-5-11(6-2)9-10-15-14(12,8-4)13-7-3/h5-10H2,1-4H3
    Key: QNGZOSUHNXJPIY-UHFFFAOYSA-N
  • CCN(CC)CC[Se]P(=O)(CC)OCC
Properties
C10H24NO2PSe
Molar mass 300.252 g·mol−1
Hazards
Lethal dose or concentration (LD, LC):
21 μg/kg (mouse, subcutaneous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Selenophos is an extremely potent organophosphate acetylcholinesterase inhibitor.[3] It is the selenium analog of the VE nerve agent.

See also

References

  1. ^ Nachmansohn, David (1 July 1969). "Proteins of Excitable Membranes". The Journal of General Physiology. 54 (1): 187–224. doi:10.1085/jgp.54.1.187. PMC 2225914. PMID 19873642.
  2. ^ Mager, Peter P. (1984). Multidimensional pharmacochemistry : design of safer drugs. Orlando: Academic Press. p. 354. ISBN 978-0-12-465020-6.
  3. ^ Akerfeldt, Stig.; Fagerlind, Lars. (January 1967). "Selenophosphorus Compounds as Powerful Cholinesterase Inhibitors". Journal of Medicinal Chemistry. 10 (1): 115–116. doi:10.1021/jm00313a032. PMID 6031689.
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