Conodurine

Conodurine
Names

IUPAC name methyl 17-ethyl-5-[(15Z)-15-ethylidene-18-methoxycarbonyl-17-methyl-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraen-12-yl]-6-methoxy-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraene-1-carboxylate
Identifiers
CAS Number	2665-57-8^Y
3D model (JSmol)	Interactive image
ChemSpider	57260028
PubChem CID	5477056
UNII	GEA6LKA5NH^Y
CompTox Dashboard (EPA)	DTXSID50420416
InChI InChI=1S/C43H52N4O5/c1-7-24-17-23-20-43(42(49)52-6)39-28(15-16-47(21-23)40(24)43)27-13-14-34(50-4)36(38(27)45-39)31-18-29-25(8-2)22-46(3)33(35(29)41(48)51-5)19-30-26-11-9-10-12-32(26)44-37(30)31/h8-14,23-24,29,31,33,35,40,44-45H,7,15-22H2,1-6H3/b25-8+ Key: QJHYXWBJZHUJGS-ZNLRHDTNSA-N
SMILES CCC1CC2CC3(C1N(C2)CCC4=C3NC5=C4C=CC(=C5C6CC7C(C(CC8=C6NC9=CC=CC=C89)N(CC7=CC)C)C(=O)OC)OC)C(=O)OC
Properties
Chemical formula	C₄₃H₅₂N₄O₅
Molar mass	704.912 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Conodurine is an acetylcholinesterase inhibitor and butyrylcholinesterase inhibitor isolated from Tabernaemontana.^[1]^[2]^[3]

References

^ Vieira, IJ; Medeiros, WL; Monnerat, CS; Souza, JJ; Mathias, L; Braz-Filho, R; Pinto, AC; Sousa, PM; Rezende, CM; Epifanio Rde, A (Sep 2008). "Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures". An. Acad. Bras. Ciênc. 80 (3): 419–26. doi:10.1590/s0001-37652008000300003. PMID 18797794.
^ "Annals of the Brazilian Academy of Sciences" (PDF).
^ Kam TS, Sim KM (July 2003). "Conodurine, conoduramine, and ervahanine derivatives from Tabernaemontana corymbosa". Phytochemistry. 63 (5): 625–9. doi:10.1016/s0031-9422(03)00087-6. PMID 12809725.

Acetylcholine metabolism and transport modulators

Enzyme
(modulators)

ChATTooltip Choline acetyltransferase	Inhibitors: 1-(-Benzoylethyl)pyridinium 2-(α-Naphthoyl)ethyltrimethylammonium 3-Chloro-4-stillbazole 4-(1-Naphthylvinyl)pyridine Acetylseco hemicholinium-3 Acryloylcholine AF64A B115 BETA CM-54,903 N,N-Dimethylaminoethylacrylate N,N-Dimethylaminoethylchloroacetate
AChETooltip Acetylcholinesterase	Inhibitors: Reversible: Carbamates: Aldicarb Aminocarb Bendiocarb Bufencarb Carbaryl Carbendazim Carbetamide Carbofuran Carbosulfan Chlorbufam Chloropropham Dimetilan Ethienocarb Ethiofencarb Fenobucarb Formetanate Formparanate Methiocarb Methomyl Metolcarb Miotine Oxamyl Phenmedipham Pinmicarb Pirimicarb Promecarb Propamocarb Propham Propoxur Thiodicarb Thiofanox; Stigmines: Distigmine Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride Ladostigil Minaprine Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide) T-1123 T-1152 T-1194 TL-599 TL-1238 Tacrine Zanapezil Irreversible: Organophosphates: 2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate Acephate Armine Azinphos-ethyl Azinphos-methyl BAY-29952 Bensulide Cadusafos Carbophenothion Chlorethoxyfos Chlorfenvinphos Chlorpyrifos Chlorpyrifos-methyl Coumaphos Crotylsarin Cyanophos Cyclosarin (GF) Demephion Demeton Demeton-S-methyl Dialifor Diazinon Dichlorvos Dicrotophos Dicyclohexyl phosphorofluoridate Diisopropylphosphate Diisopropyl fluorophosphate Dimefox Dimethoate Dimethyl 4-(methylthio)phenyl phosphate Dioxathion Disulfoton EA-2012 EA-2054 EA-2098 EA-2192 EA-2613 EA-3148 EA-4352 Echothiophate Ethylsarin (GE) Endothion EPN Ethion Ethoprop Fenamiphos Fenitrothion Fenthion Fluorotabun Fonofos Formothion Fosthiazate GD-42 GH GT-45 GV Guanitoxin Hexaethyl tetraphosphate (HETP) Isofluorophate Isoxathion Leptophos Malaoxon Malathion Mazidox Methamidophos Methidathion Methyl phenkapton Methylfluorophosphonylcholine (MFPCh) Metrifonate Mevinphos Mipafox Monocrotophos MSPI Naled Novichok agent Omethoate Oxydemeton-methyl Paraoxon Parathion Parathion-methyl Phorate Phosalone Phosfolan Phosmet Phosphamidon Phoxim Pirimiphos-methyl Profenofos Prothoate R-16661 Ro 3-0340 Ro 3-0346 Ro 3-0347 Ro 3-0351 Ro 3-0352 Ro 3-0397 Ro 3-0411 Ro 3-0412 Ro 3-0417 Ro 3-0419 Ro 3-0422 Ro 3-0433 Ronnel Sarin (GB) Schradan Soman (GD) Sulfotep (TEDP) Tabun (GA) Tebupirimfos Temefos Terbufos Tetrachlorvinphos Tetraethyl pyrophosphate (TEPP) Triazofos Tribufos Trichlorfon Trichloronate Tricresyl phosphate VE VG VM VP VS VR VX; Others: Demecarium Fasciculins (green mamba toxins) (1, 2, 3, 4) Onchidal (Onchidella binneyi) Methanesulfonyl fluoride Unsorted: α-Pinene α-Viniferin Affinine Affinisine Arisugacin A Bulbocapnine Conodurine Coronaridine Corydaline Corynoline Crimidine Cyclanoline Cymserine Harmaline Kobophenol A Lactucopicrin Lycorine Phosacetim Rosmarinic acid Stercuronium iodide Taspine Tetrahydrocannabinol Ungeremine Ungiminorine Dimethylcarbamoyl fluoride BW284C51 TMTFA 3152 CT Reactivators: Asoxime chloride Methoxime Obidoxime Pralidoxime Trimedoxime bromide
BChETooltip Butyrylcholinesterase	Inhibitors: Affinine Affinisine Conodurine Cymserine Ladostigil Profenamine (ethopropazine) Rivastigmine Tacrine ZINC-12613047 Many of the other AChE inhibitors listed above

Transporter
(modulators)

CHTTooltip Choline transporter	Inhibitors: Hemicholinium-3 (hemicholine) Triethylcholine Enhancers: Coluracetam
VAChTTooltip Vesicular acetylcholine transporter	Inhibitors: Vesamicol

Release
(modulators)

Inhibitors	SNAP-25Tooltip Synaptosomal-associated protein 25 inactivators: Botulinum toxin (A, C, E) VAMPTooltip Vesicle-associated membrane protein inactivators: Botulinum toxin (B, D, F, G) Others: Bungarotoxins (β-bungarotoxin, γ-bungarotoxin)
Enhancers	LPHNTooltip Latrophilin agonists: α-Latrotoxin Others: Atracotoxins (e.g., robustoxin, versutoxin) Crotoxin

See also: Receptor/signaling modulators; Muscarinic acetylcholine receptor modulators; Nicotinic acetylcholine receptor modulators

This article about an alkaloid is a stub. You can help Wikipedia by expanding it.

Read other articles:

Hans-Georg Gadamer

Hans-Georg GadamerHans-Georg Gadamer, c. 2000Lahir11 Februari 1900 Marburg, Jerman)Meninggal13 Maret 2002 Heidelberg, Jerman)EraFilsafat abad ke-20KawasanFilsuf BaratAliranFilsafat kontinental, HermeneutikaMinat utamaMetafisika, Epistemologi, Bahasa, Ontologi, EstetikaGagasan pentinghermeneutika filosofis, 'filsafat praktis', semua produk dari tradisi yang berada dalam tradisi tersebut, bahasa sebagai kesatuan dari antara yang tak terhingga dengan yang terhingga Dipengaruhi Plato, ...

Ulmus 'Clusius'

Elm cultivar Ulmus 'Clusius'Ulmus 'Clusius', Netherlands.GenusUlmusHybrid parentage('Exoniensis' × U. wallichiana) × 'Bea Schwarz' selfedCultivar'Clusius'OriginWageningen, The Netherlands Ulmus 'Clusius' is a Dutch hybrid elm cultivar raised at the Dorschkamp Research Institute for Forestry & Landscape Planning, Wageningen, and released to commerce in 1983. 'Clusius' was derived from a crossing of the same Dutch clones that produced the fastigiate 'Lobel' released in 1973: '202' ('Exoni...

Irvine, California

Sudut kota Irvine Irvine merupakan sebuah kota di negara bagian California. Amerika Serikat. Kota ini terletak di Orange County, sebelah tenggara dari Los Angeles. Irvine berjarak kira-kira 80 km dari pusat kota Los Angeles, dan dapat dicapai melalui jalan bebas hambatan Freeway 5, atau dari Long Beach melalui Freeway 405. Penduduk Irvine lebih dari 215 ribu jiwa. Pusat kota Irvine merupakan daerah bisnis modern, dan merupakan kota besar dan penting di Orange County bersama-sama dengan Santa ...

Presidency of James Madison

U.S. presidential administration from 1809 to 1817 Presidency of James MadisonMarch 4, 1809 – March 4, 1817CabinetSee listPartyDemocratic-RepublicanElection18081812SeatWhite House← Thomas JeffersonJames Monroe → Dorsett seal The presidency of James Madison began on March 4, 1809, when James Madison was inaugurated as President of the United States, and ended on March 4, 1817. Madison, the fourth United States president, took office after defeating Federalist C...

ZOE Broadcasting Network

Philippine television network This article is about the Philippine television network (Light TV). For the American television network of the same name, see Light TV (U.S.). This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: ZOE Broadcasting Network – news · newspapers · books · scholar · JSTOR (November 2023) (...

Claude-Sylvestre Colaud

Claude Silvestre, Count Colaud. Claude Silvestre, Count Colaud (12 December 1754 – 4 December 1819) was a French Napoleonic general and senator.[1] Biography Colaud was born at Briançon on 12 December 1754. In 1801, for his military services, he was made a senator of the French Consulate by the First Consul Napoleon Bonaparte. He was also made a Grand Officer of the Legion of Honour. He died in Paris on 4 December 1819. His name is inscribed on column five northern pillar of the Ar...

George Sugarman

American painter This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: George Sugarman – news · newspapers · books · scholar · JSTOR (October 2015) (Learn how and when to remove this template message) Black and White Horizontal (1993/99), by George Sugarman. Palma de Mallorca/Spain George Sugarman (11 May 1912 –...

Mayenne (rivière)

Pour les articles homonymes, voir Mayenne. la Mayenne La Mayenne et l'île de Sainte-Apollonie près d'Entrammes. Cours de la Mayenne (carte interactive). Caractéristiques Longueur 202,6 km [1] Bassin 5 820 km2 Bassin collecteur Loire Débit moyen 50 m3/s (la confluence avec la Sarthe) Régime pluvial océanique Cours Source Pied du mont des Avaloirs · Localisation Lalacelle · Altitude 344 m · Coordonnées 48° 27′ 23″ N, 0° 07′ 55...

Badminton

Racquet sport This article is about the sport. For other uses, see Badminton (disambiguation). BadmintonTwo Chinese pairs compete in the mixed doubles gold medal match of the 2012 OlympicsHighest governing bodyBadminton World FederationFirst played19th century in Badminton HouseCharacteristicsContactNoneTeam membersSingles or doublesMixed-sexYesTypeRacquet sport, Net sportEquipmentShuttlecock, racquetPresenceOlympic1992–presentWorld Games1981 Badminton is a racquet sport played using r...

Mignaloux-Beauvoir

Mignaloux-BeauvoircomuneMignaloux-Beauvoir – Veduta LocalizzazioneStato Francia Regione Nuova Aquitania Dipartimento Vienne ArrondissementPoitiers CantonePoitiers-4 TerritorioCoordinate46°33′N 0°25′E / 46.55°N 0.416667°E46.55; 0.416667 (Mignaloux-Beauvoir)Coordinate: 46°33′N 0°25′E / 46.55°N 0.416667°E46.55; 0.416667 (Mignaloux-Beauvoir) Superficie21,62 km² Abitanti4 211[1] (2009) Densità194,77 ab./km² Al...

大字 (数字)

この項目には、一部のコンピュータや閲覧ソフトで表示できない文字が含まれています（詳細）。数字の大字（だいじ）は、漢数字の一種。通常用いる単純な字形の漢数字（小字）の代わりに同じ音の別の漢字を用いるものである。概要壱万円日本銀行券（「壱」が大字）弐千円日本銀行券（「弐」が大字）漢数字には「一」「二」「三」と続く小字と、「壱」「�...

约翰斯顿环礁

此條目可参照英語維基百科相應條目来扩充。 (2021年5月6日)若您熟悉来源语言和主题，请协助参考外语维基百科扩充条目。请勿直接提交机械翻译，也不要翻译不可靠、低品质内容。依版权协议，译文需在编辑摘要注明来源，或于讨论页顶部标记{{Translated page}}标签。约翰斯顿环礁Kalama Atoll 美國本土外小島嶼 Johnston Atoll 旗幟颂歌：《星條旗》The Star-Spangled Banner約翰斯頓環礁�...

Orang Seletar language

Language Orang SeletarNative toMalaysia, SingaporeEthnicityOrang SeletarNative speakers1,200 (2018)[1]Language familyAustronesian Malayo-PolynesianMalayicMalay?Orang SeletarWriting systemUnwrittenLanguage codesISO 639-3orsGlottologoran1259ELPOrang SeletarOrang Seletar is classified as Critically Endangered by the UNESCO Atlas of the World's Languages in Danger[2] Orang Seletar (Slitar) is a language of the Orang Laut of the south coast of the Malay Peninsula.[1&#...

Fragata

Para Ave Fragata, véase Fregata. Fragata moderna Almirante Sergei Gorshkov de la Armada rusa. El término «fragata» volvió a aparecer en las marinas de guerra a partir de los años 50 del siglo XX. Las diferencias entre una fragata y un destructor son cada vez más difusas. De arriba abajo; la fragata neerlandesa Hr.Ms. De Ruyter (F804), la española Álvaro de Bazán (F-101), la canadiense HMCS Charlottetown (FFH 339) y la alemana Rheinland-Pfalz (F209) navegando juntas en 2012. La...

2021 Pakistan Super League

Cricket tournament Cricket tournament Pakistan Super League 2021Dates20 February – 24 June 2021Administrator(s)Pakistan Cricket BoardCricket formatTwenty20Tournament format(s)Double round robin and playoffsHost(s) Pakistan United Arab Emirates ChampionsMultan Sultans (1st title)Runners-upPeshawar ZalmiParticipants6Matches34Attendance143,854 (4,231 per match)Player of the seriesSohaib Maqsood (MS) (428 runs)Most runsBabar Azam (KK) (554)Most wicketsShahnawaz Dahani (MS) (20)Official website...

Amazon Go

Convenience store chain operated by Amazon.com Amazon GoThe first Amazon Go location, at Day 1 in SeattleCompany typeSubsidiaryIndustryRetailConvenience storesFoundedDecember 2016; 7 years ago (2016-12)Seattle, Washington, U.S.Number of locations22 (2024[1])Area servedSeattleNew York CityChicagoLos AngelesLondonParentAmazonWebsiteamazon.com/go Amazon Go is a chain of convenience stores in the United States and the United Kingdom, operated by the online reta...

Michael Jennings (rugby league)

Australia & Tonga international rugby league footballer Michael JenningsPersonal informationFull nameMichael JenningsBorn (1988-04-20) 20 April 1988 (age 36)Blacktown, New South Wales, AustraliaHeight180 cm (5 ft 11 in)Weight96 kg (15 st 2 lb)Playing informationPositionCentre Club Years Team Pld T G FG P 2007–12 Penrith Panthers 122 71 0 0 284 2013–15 Sydney Roosters 71 41 0 0 164 2016–20 Parramatta Eels 105 42 0 0 168 2024– Sydney Roosters ...

محمد صالح (لاعب كرة قدم)

لمعانٍ أخرى، طالع محمد صالح (توضيح). محمد صالح معلومات شخصية الميلاد 6 يونيو 1980 (العمر 44 سنة)انجمينا الطول 1.80 م (5 قدم 11 بوصة) مركز اللعب وسط الجنسية تشاد المسيرة الاحترافية1 سنوات فريق م. (هـ.) 2002–2003 لوسيتانيوس سان مور [الإنجليزية]‏ 2003–2008 أنجيه 1 (0) 2005�...

الحفة

الحفة الاسم الرسمي الحفة الإحداثيات 35°35′N 36°2′E / 35.583°N 36.033°E / 35.583; 36.033 تقسيم إداري البلد سوريا محافظة محافظة اللاذقية منطقة منطقة الحفة ناحية مركز الحفة عاصمة لـ منطقة الحفة خصائص جغرافية ارتفاع 310 متر عدد السكان (تعداد عام 2004) الم...

Libyan Americans

Americans of Libyan birth or descent Ethnic group Libyan AmericansTotal population2,979 (2000 US Census)[1] 9,000 (Libyan-born; 2008–2012)[2]Regions with significant populationsCaliforniaLanguagesArabic (Libyan Arabic), American English, Amazigh languages, Hebrew (Jewish population)ReligionSunni Islam, Judaism Libyan Americans (Arabic: الليبيون الأمريكيون, romanized: al-Lībīyūn al-Amirīkīyūn) are United States citizens of Libyan descent or Libyan...

Conodurine

See also

References

Read other articles: