DCP2

DCP2

معرفات

أسماء بديلة

DCP2, NUDT20, decapping mRNA 2

معرفات خارجية

الوراثة المندلية البشرية عبر الإنترنت 609844 MGI: MGI:1917890 HomoloGene: 13968 GeneCards: 167227

علم الوجود الجيني
وظائف جزيئية	• m7G(5')pppN diphosphatase activity • ربط أيون المنغنيز • ربط أيون فلزي • ‏GO:0001948، ‏GO:0016582 ربط بروتيني • exoribonuclease activity, producing 5'-phosphomonoesters • RNA binding • نشاط هيدرولاز • 5'-3' exoribonuclease activity • telomerase RNA binding
مكونات خلوية	• سيتوبلازم • مركب إسكات مستحث بالرنا • عصارة خلوية • أجسام P • بلازم نووي • موصل خلوي • نواة • حبيبة رنا
عمليات حيوية	• mRNA catabolic process • regulation of mRNA stability • deadenylation-dependent decapping of nuclear-transcribed mRNA • exonucleolytic catabolism of deadenylated mRNA • histone mRNA catabolic process • RNA phosphodiester bond hydrolysis, exonucleolytic • تفكك متوسط بلا معنى • negative regulation of telomere maintenance via telomerase • regulation of telomerase RNA localization to Cajal body
المصادر:Amigo / QuickGO

تماثلات متسلسلة

أنواع

الإنسان

الفأر

ENSG00000172795

ENSMUSG00000024472

يونيبروت


Q8IU60


Q9CYC6

RefSeq (رنا مرسال.)


‏NM_152624، ‏NR_038352، ‏XM_047416865، ‏XM_047416866، ‏XM_047416867 NM_001242377، ‏NM_152624، ‏NR_038352، ‏XM_047416865، ‏XM_047416866، ‏XM_047416867


NM_027490

RefSeq (بروتين)


‏NP_689837، ‏XP_016864652 NP_001229306، ‏NP_689837، ‏XP_016864652


NP_081766

الموقع (UCSC

n/a

Chr 18: 44.51 – 44.56 Mb

بحث ببمد

ويكي بيانات

اعرض/عدّل إنسان

اعرض/عدّل فأر

DCP2‏ (Decapping mRNA 2) هوَ بروتين يُشَفر بواسطة جين DCP2 في الإنسان.^[1]^[1]^[2]^[3]

الوظيفة

هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018)

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018)

المراجع

^ ^ا ^ب "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)". مؤرشف من الأصل في 2010-12-05.
^ Lykke-Andersen J (نوفمبر 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol. ج. 22 ع. 23: 8114–21. DOI:10.1128/MCB.22.23.8114-8121.2002. PMC:134073. PMID:12417715.
^ Wang Z، Jiao X، Carr-Schmid A، Kiledjian M (أكتوبر 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A. ج. 99 ع. 20: 12663–8. Bibcode:2002PNAS...9912663W. DOI:10.1073/pnas.192445599. PMC:130517. PMID:12218187.

قراءة متعمقة

Ueno K، Kumagai T، Kijima T، وآخرون (1998). "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer". Hum. Genet. ج. 102 ع. 1: 63–8. DOI:10.1007/s004390050655. PMID:9490301.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. Bibcode:2002PNAS...9916899M. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
van Dijk E، Cougot N، Meyer S، وآخرون (2004). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures". EMBO J. ج. 21 ع. 24: 6915–24. DOI:10.1093/emboj/cdf678. PMC:139098. PMID:12486012.
Ingelfinger D، Arndt-Jovin DJ، Lührmann R، Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. ج. 8 ع. 12: 1489–501. DOI:10.1017/S1355838202021726. PMC:1370355. PMID:12515382.
Grzymski EC (2003). "Visualizing an mRNA destruction line". Nat. Struct. Biol. ج. 10 ع. 6: 416. DOI:10.1038/nsb0603-416. PMID:12768200.
Piccirillo C، Khanna R، Kiledjian M (2003). "Functional characterization of the mammalian mRNA decapping enzyme hDcp2". RNA. ج. 9 ع. 9: 1138–47. DOI:10.1261/rna.5690503. PMC:1370477. PMID:12923261.
Lejeune F، Li X، Maquat LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. ج. 12 ع. 3: 675–87. DOI:10.1016/S1097-2765(03)00349-6. PMID:14527413.
Ota T، Suzuki Y، Nishikawa T، وآخرون (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. ج. 36 ع. 1: 40–5. DOI:10.1038/ng1285. PMID:14702039.
Cougot N، Babajko S، Séraphin B (2004). "Cytoplasmic foci are sites of mRNA decay in human cells". J. Cell Biol. ج. 165 ع. 1: 31–40. DOI:10.1083/jcb.200309008. PMC:2172085. PMID:15067023.
Lehner B، Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. ج. 14 ع. 7: 1315–23. DOI:10.1101/gr.2122004. PMC:442147. PMID:15231747.
Liu SW، Jiao X، Liu H، وآخرون (2004). "Functional analysis of mRNA scavenger decapping enzymes". RNA. ج. 10 ع. 9: 1412–22. DOI:10.1261/rna.7660804. PMC:1370627. PMID:15273322.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Liu J، Valencia-Sanchez MA، Hannon GJ، Parker R (2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies". Nat. Cell Biol. ج. 7 ع. 7: 719–23. DOI:10.1038/ncb1274. PMC:1855297. PMID:15937477.
Fenger-Grøn M، Fillman C، Norrild B، Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Mol. Cell. ج. 20 ع. 6: 905–15. DOI:10.1016/j.molcel.2005.10.031. PMID:16364915.
Wichroski MJ، Robb GB، Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies". PLoS Pathog. ج. 2 ع. 5: e41. DOI:10.1371/journal.ppat.0020041. PMC:1458959. PMID:16699599.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Chu CY، Rana TM (2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54". PLoS Biol. ج. 4 ع. 7: e210. DOI:10.1371/journal.pbio.0040210. PMC:1475773. PMID:16756390.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Olsen JV، Blagoev B، Gnad F، وآخرون (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. ج. 127 ع. 3: 635–48. DOI:10.1016/j.cell.2006.09.026. PMID:17081983.

جينات الكروموسوم 5

جينات الكروموسوم 5

هذه بذرة مقالة عن جين على كروموسوم 5 بحاجة للتوسيع. فضلًا شارك في تحريرها.

تعديل ما بعد النسخ

توصيل الرنا

إنترون / إكسون snRNP جسيم التضفير صغير U1 وصل بديل
عوامل الرنا قبل الرسول	PLRG1 PRPF3 PRPF4 PRPF4B PRPF6 PRPF8 PRPF18 PRPF19 PRPF31 PRPF38A PRPF38B PRPF39 PRPF40A PRPF40B

سيتوسولي

التصنيفات الطبية	دليل الوراثة المندلية عند البشر (OMIM): 609844
المعرفات الخارجية	Ensembl Transcript ID: ENST00000674880 نظام اللغة الطبية الموحدة (UMLS CUI): C1539227

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