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WASP family member 2
معرفات
أسماء بديلة	WASP family protein member 2, protein WAVE-2, wiskott-Aldrich syndrome protein family member 2, WASP family Verprolin-homologous protein 2, WASF2, suppressor of cyclic-AMP receptor (WASP-family), WAS protein family member 2, verprolin homology domain-containing protein 2, WASP family protein member 4, putative Wiskott-Aldrich syndrome protein family member 4
معرفات خارجية
تماثلات متسلسلة
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	ويكي بيانات
اعرض/عدّل إنسان

WASF2‏ (WAS protein family member 2) هوَ بروتين يُشَفر بواسطة جين WASF2 في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: WASF2 WAS protein family, member 2". مؤرشف من الأصل في 2010-12-05.
^ Suetsugu S، Miki H، Takenawa T (يوليو 1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem Biophys Res Commun. ج. 260 ع. 1: 296–302. DOI:10.1006/bbrc.1999.0894. PMID:10381382.

قراءة متعمقة

Jones GE (2000). "Cellular signaling in macrophage migration and chemotaxis". J. Leukoc. Biol. ج. 68 ع. 5: 593–602. PMID:11073096.
She HY، Rockow S، Tang J، وآخرون (1997). "Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells". Mol. Biol. Cell. ج. 8 ع. 9: 1709–21. DOI:10.1091/mbc.8.9.1709. PMC:305731. PMID:9307968.
Bear JE، Rawls JF، Saxe CL (1998). "SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development". J. Cell Biol. ج. 142 ع. 5: 1325–35. DOI:10.1083/jcb.142.5.1325. PMC:2149354. PMID:9732292.
Wu Y، Dowbenko D، Lasky LA (1998). "PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase". J. Biol. Chem. ج. 273 ع. 46: 30487–96. DOI:10.1074/jbc.273.46.30487. PMID:9804817.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Machesky LM، Insall RH (1999). "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex". Curr. Biol. ج. 8 ع. 25: 1347–56. DOI:10.1016/S0960-9822(98)00015-3. PMID:9889097.
Qualmann B، Roos J، DiGregorio PJ، Kelly RB (1999). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein". Mol. Biol. Cell. ج. 10 ع. 2: 501–13. DOI:10.1091/mbc.10.2.501. PMC:25183. PMID:9950691.
Stewart DM، Tian L، Nelson DL (1999). "Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein". J. Immunol. ج. 162 ع. 8: 5019–24. PMID:10202051.
Morrogh LM، Hinshelwood S، Costello P، وآخرون (1999). "The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro". Eur. J. Immunol. ج. 29 ع. 7: 2269–79. DOI:10.1002/(SICI)1521-4141(199907)29:07<2269::AID-IMMU2269>3.0.CO;2-#. PMID:10427990.
Banin S، Gout I، Brickell P (1999). "Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase". Mol. Biol. Rep. ج. 26 ع. 3: 173–7. DOI:10.1023/A:1006954206151. PMID:10532312.
Westphal RS، Soderling SH، Alto NM، وآخرون (2000). "Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold". EMBO J. ج. 19 ع. 17: 4589–600. DOI:10.1093/emboj/19.17.4589. PMC:302050. PMID:10970852.
Miki H، Yamaguchi H، Suetsugu S، Takenawa T (2001). "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling". Nature. ج. 408 ع. 6813: 732–5. DOI:10.1038/35047107. PMID:11130076.
Marchand JB، Kaiser DA، Pollard TD، Higgs HN (2001). "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex". Nat. Cell Biol. ج. 3 ع. 1: 76–82. DOI:10.1038/35050590. PMID:11146629.
Millard TH، Machesky LM (2001). "The Wiskott-Aldrich syndrome protein (WASP) family". Trends Biochem. Sci. ج. 26 ع. 3: 198–9. DOI:10.1016/S0968-0004(01)01788-1. PMID:11246027.
Worby CA، Simonson-Leff N، Clemens JC، وآخرون (2002). "Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance". J. Biol. Chem. ج. 277 ع. 11: 9422–8. DOI:10.1074/jbc.M110172200. PMID:11773052.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Miki H، Takenawa T (2002). "WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac". Biochem. Biophys. Res. Commun. ج. 293 ع. 1: 93–9. DOI:10.1016/S0006-291X(02)00218-8. PMID:12054568.
Eden S، Rohatgi R، Podtelejnikov AV، وآخرون (2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature. ج. 418 ع. 6899: 790–3. Bibcode:2002Natur.418..790E. DOI:10.1038/nature00859. PMID:12181570.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. Bibcode:2002PNAS...9916899M. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Innocenti M، Zucconi A، Disanza A، وآخرون (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nat. Cell Biol. ج. 6 ع. 4: 319–27. DOI:10.1038/ncb1105. PMID:15048123.