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FGFR2
Наявні структури
PDB	Пошук ортологів: PDBe RCSB
Список кодів PDB
	1DJS, 1E0O, 1EV2, 1GJO, 1II4, 1IIL, 1NUN, 1OEC, 1WVZ, 2FDB, 2PSQ, 2PVF, 2PVY, 2PWL, 2PY3, 2PZ5, 2PZP, 2PZR, 2Q0B, 3B2T, 3CAF, 3CLY, 3CU1, 3DAR, 3EUU, 3OJ2, 3OJM, 3RI1, 4J95, 4J96, 4J97, 4J98, 4J99, 4J23, 4WV1
Ідентифікатори
Символи	FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, fibroblast growth factor receptor 2
Зовнішні ІД	OMIM: 176943 MGI: 95523 HomoloGene: 22566 GeneCards: FGFR2
Пов'язані генетичні захворювання
	рак молочної залози, Crouzon syndrone, Jackson–Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, McGillivray syndrome, LADD syndrome, синдром Антлі—Бікслера, Краніосиностоз
Реагує на сполуку
	Нінтеданіб, Нінтеданіб, infigratinib, brivanib, erdafitinib, lucitanib, orantinib
Онтологія гена
Молекулярна функція	• heparin binding; • kinase activity; • transmembrane receptor protein tyrosine kinase activity; • fibroblast growth factor binding; • ATP binding; • protein kinase activity; • fibroblast growth factor-activated receptor activity; • transferase activity; • protein homodimerization activity; • GO:0001948, GO:0016582 protein binding; • nucleotide binding; • protein tyrosine kinase activity; • 1-phosphatidylinositol-3-kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • identical protein binding; • receptor tyrosine kinase; • transmembrane signaling receptor activity;
Клітинна компонента	• цитоплазма; • мембрана; • extracellular region; • клітинне ядро; • cell surface; • integral component of membrane; • комплекс Ґольджі; • внутрішньоклітинна мембранна органела; • GO:0005578 Позаклітинна матриця; • клітинна мембрана; • нуклеоплазма; • cell cortex; • integral component of plasma membrane; • excitatory synapse; • GO:0016023 cytoplasmic vesicle; • receptor complex; • collagen-containing extracellular matrix;
Біологічний процес	• fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; • ureteric bud development; • organ growth; • limb bud formation; • embryonic pattern specification; • bud elongation involved in lung branching; • positive regulation of canonical Wnt signaling pathway; • membranous septum morphogenesis; • fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; • embryonic organ morphogenesis; • post-embryonic development; • squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; • branching morphogenesis of a nerve; • reproductive structure development; • fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell; • ventricular cardiac muscle tissue morphogenesis; • protein phosphorylation; • positive regulation of cardiac muscle cell proliferation; • mesenchymal cell differentiation; • positive regulation of mesenchymal cell proliferation; • regulation of osteoblast differentiation; • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; • Ангіогенез; • prostate gland morphogenesis; • positive regulation of ERK1 and ERK2 cascade; • orbitofrontal cortex development; • negative regulation of epithelial cell proliferation; • animal organ morphogenesis; • embryonic digestive tract morphogenesis; • hair follicle morphogenesis; • morphogenesis of embryonic epithelium; • branch elongation involved in salivary gland morphogenesis; • GO:0097285 апоптоз; • branching involved in salivary gland morphogenesis; • cell fate commitment; • lung development; • embryonic organ development; • fibroblast growth factor receptor signaling pathway involved in hemopoiesis; • in utero embryonic development; • lateral sprouting from an epithelium; • positive regulation of Wnt signaling pathway; • gland morphogenesis; • positive regulation of cell cycle; • branching involved in labyrinthine layer morphogenesis; • branching involved in prostate gland morphogenesis; • regulation of ERK1 and ERK2 cascade; • protein autophosphorylation; • mammary gland bud formation; • pyramidal neuron development; • lacrimal gland development; • positive regulation of MAPK cascade; • regulation of smooth muscle cell differentiation; • regulation of cell fate commitment; • bone mineralization; • regulation of branching involved in prostate gland morphogenesis; • positive regulation of epithelial cell proliferation involved in lung morphogenesis; • epithelial cell differentiation; • фосфорилювання; • multicellular organism growth; • positive regulation of epithelial cell proliferation; • ventricular zone neuroblast division; • epidermis morphogenesis; • skeletal system morphogenesis; • regulation of morphogenesis of a branching structure; • GO:1901227 negative regulation of transcription by RNA polymerase II; • outflow tract septum morphogenesis; • odontogenesis; • Епітеліально-мезенхімальний перехід; • lung alveolus development; • lung lobe morphogenesis; • midbrain development; • positive regulation of smooth muscle cell proliferation; • fibroblast growth factor receptor signaling pathway involved in mammary gland specification; • mesenchymal cell proliferation involved in lung development; • prostate epithelial cord elongation; • mesenchymal cell differentiation involved in lung development; • аксоноґенеза; • regulation of multicellular organism growth; • otic vesicle formation; • epithelial cell proliferation involved in salivary gland morphogenesis; • cell-cell signaling; • regulation of fibroblast growth factor receptor signaling pathway; • bone morphogenesis; • MAPK cascade; • regulation of osteoblast proliferation; • positive regulation of phospholipase activity; • fibroblast growth factor receptor signaling pathway; • regulation of smoothened signaling pathway; • inner ear morphogenesis; • positive regulation of cell population proliferation; • mesodermal cell differentiation; • peptidyl-tyrosine phosphorylation; • digestive tract development; • lung-associated mesenchyme development; • bone development; • positive regulation of cell division; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • phosphatidylinositol phosphate biosynthetic process; • phosphatidylinositol-3-phosphate biosynthetic process; • endochondral bone growth; • response to lipopolysaccharide; • Загоєння ран; • cellular response to fibroblast growth factor stimulus; • response to ethanol; • cellular response to retinoic acid; • cellular response to transforming growth factor beta stimulus; • embryonic cranial skeleton morphogenesis; • positive regulation of protein kinase B signaling; • negative regulation of signal transduction; • диференціація клітин; • negative regulation of apoptotic process; • transmembrane receptor protein tyrosine kinase signaling pathway;
	Джерела:Amigo / QuickGO
Шаблон експресії
	; ; ; ;
	Більше даних
Ортологи
	2263
	14183
	ENSG00000066468
	ENSMUSG00000030849
	P21802
	P21803
NM_000141; NM_001144913; NM_001144914; NM_001144915; NM_001144916;
	NM_001144917; NM_001144918; NM_001144919; NM_022970; NM_022971; NM_022972; NM_022973; NM_022974; NM_022975; NM_022976; NM_023028; NM_023029; NM_023030; NM_001320654; NM_001320658; NM_023031
	NM_010207; NM_201601; NM_001347638
NP_000132; NP_001138385; NP_001138386; NP_001138387; NP_001138388;
	NP_001138389; NP_001138390; NP_001138391; NP_001307583; NP_001307587; NP_075259; NP_075418
	NP_001334567; NP_034337; NP_963895
	Вікідані
Див./Ред. для людей	Див./Ред. для мишей

FGFR2 (англ. Fibroblast growth factor receptor 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми.^[5] Довжина поліпептидного ланцюга білка становить 821 амінокислот, а молекулярна маса — 92 025^[6].

Послідовність амінокислот

10	20	30	40	50
MVSWGRFICL	VVVTMATLSL	ARPSFSLVED	TTLEPEEPPT	KYQISQPEVY
VAAPGESLEV	RCLLKDAAVI	SWTKDGVHLG	PNNRTVLIGE	YLQIKGATPR
DSGLYACTAS	RTVDSETWYF	MVNVTDAISS	GDDEDDTDGA	EDFVSENSNN
KRAPYWTNTE	KMEKRLHAVP	AANTVKFRCP	AGGNPMPTMR	WLKNGKEFKQ
EHRIGGYKVR	NQHWSLIMES	VVPSDKGNYT	CVVENEYGSI	NHTYHLDVVE
RSPHRPILQA	GLPANASTVV	GGDVEFVCKV	YSDAQPHIQW	IKHVEKNGSK
YGPDGLPYLK	VLKAAGVNTT	DKEIEVLYIR	NVTFEDAGEY	TCLAGNSIGI
SFHSAWLTVL	PAPGREKEIT	ASPDYLEIAI	YCIGVFLIAC	MVVTVILCRM
KNTTKKPDFS	SQPAVHKLTK	RIPLRRQVTV	SAESSSSMNS	NTPLVRITTR
LSSTADTPML	AGVSEYELPE	DPKWEFPRDK	LTLGKPLGEG	CFGQVVMAEA
VGIDKDKPKE	AVTVAVKMLK	DDATEKDLSD	LVSEMEMMKM	IGKHKNIINL
LGACTQDGPL	YVIVEYASKG	NLREYLRARR	PPGMEYSYDI	NRVPEEQMTF
KDLVSCTYQL	ARGMEYLASQ	KCIHRDLAAR	NVLVTENNVM	KIADFGLARD
INNIDYYKKT	TNGRLPVKWM	APEALFDRVY	THQSDVWSFG	VLMWEIFTLG
GSPYPGIPVE	ELFKLLKEGH	RMDKPANCTN	ELYMMMRDCW	HAVPSQRPTF
KQLVEDLDRI	LTLTTNEEYL	DLSQPLEQYS	PSYPDTRSSC	SSGDDSVFSP
DPMPYEPCLP	QYPHINGSVK	T

A: Аланін

C: Цистеїн

D: Аспарагінова кислота

E: Глутамінова кислота

F: Фенілаланін

G: Гліцин

H: Гістидин

I: Ізолейцин

K: Лізин

L: Лейцин

M: Метіонін

N: Аспарагін

P: Пролін

Q: Глутамін

R: Аргінін

S: Серин

T: Треонін

V: Валін

W: Триптофан

Y: Тирозин

Кодований геном білок за функціями належить до трансфераз, кіназ, рецепторів, тирозинових протеїнкіназ, фосфопротеїнів. Задіяний у таких біологічних процесах, як апоптоз, альтернативний сплайсинг. Білок має сайт для зв'язування з АТФ, нуклеотидами, з молекулою гепарину. Локалізований у клітинній мембрані, мембрані, цитоплазматичних везикулах, апараті гольджі. Також секретований назовні.

Література

Seno M., Sasada R., Watanabe T., Ishimaru K., Igarashi K. (1991). Two cDNAs encoding novel human FGF receptor. Biochim. Biophys. Acta. 1089: 244—246. PMID 1647213 DOI:10.1016/0167-4781(91)90015-E
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
Zhang Y., Gorry M.C., Post J.C., Ehrlich G.D. (1999). Genomic organization of the human fibroblast growth factor receptor 2 (FGFR2) gene and comparative analysis of the human FGFR gene family. Gene. 230: 69—79. PMID 10196476 DOI:10.1016/S0378-1119(99)00047-5
Gray T.E., Eisenstein M., Yayon A., Givol D. (1996). Asparagine-344 is a key residue for ligand binding in keratinocyte growth factor receptor. Biochemistry. 35: 15640—15645. PMID 8961926 DOI:10.1021/bi961942c
Lu Y., Pan Z.-Z., Devaux Y., Ray P. (2003). p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death. J. Biol. Chem. 278: 10374—10380. PMID 12529371 DOI:10.1074/jbc.M205875200
Kaabeche K., Lemonnier J., Le Mee S., Caverzasio J., Marie P.J. (2004). Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J. Biol. Chem. 279: 36259—36267. PMID 15190072 DOI:10.1074/jbc.M402469200