MCAM

MCAM
Ідентифікатори
Символи MCAM, CD146, MUC18, melanoma cell adhesion molecule, HEMETCAM, MelCAM
Зовнішні ІД OMIM: 155735 MGI: 1933966 HomoloGene: 4742 GeneCards: MCAM
Ортологи
Види Людина Миша
Entrez
4162
84004
Ensembl
ENSG00000076706
ENSMUSG00000032135
UniProt
P43121
Q8R2Y2
RefSeq (мРНК)
NM_006500
NM_023061
NM_001359530
RefSeq (білок)
NP_006491
NP_075548
NP_001346459
Локус (UCSC) Хр. 11: 119.31 – 119.32 Mb Хр. 9: 44.05 – 44.05 Mb
PubMed search [1] [2]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

MCAM (англ. Melanoma cell adhesion molecule) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 646 амінокислот, а молекулярна маса — 71 607[4].

Послідовність амінокислот
1020304050
MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGL
SQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGAT
LALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPV
NSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSG
LYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTE
KVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN
DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSP
AAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKRE
AGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNL
SCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECT
ASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTER
KLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL
PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH

Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах, як клітинна адгезія, альтернативний сплайсинг. Локалізований у мембрані.

Література

  • Lehmann J.M., Riethmueller G., Johnson J.P. (1989). MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc. Natl. Acad. Sci. U.S.A. 86: 9891—9895. PMID 2602381 doi:10.1073/pnas.86.24.9891
  • Sers C., Kirsch K., Rothbaecher U., Riethmueller G., Johnson J.P. (1993). Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. Proc. Natl. Acad. Sci. U.S.A. 90: 8514—8518. PMID 8378324 doi:10.1073/pnas.90.18.8514
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 doi:10.1101/gr.2596504
  • Shih I.-M., Eleder D.E., Speicher D., Johnson J.P., Herlyn M. (1994). Isolation and functional characterization of the A32 melanoma-associated antigen. Cancer Res. 54: 2514—2520. PMID 8162602
  • Johnson J.P., Rothbacher U., Sers C. (1993). The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family. Melanoma Res. 3: 337—340. PMID 8292890

Примітки

  1. ↑ Human PubMed Reference:.
  2. ↑ Mouse PubMed Reference:.
  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:6934 (англ.) . Архів оригіналу за 21 травня 2017. Процитовано 8 вересня 2017. [Архівовано 2017-05-21 у Wayback Machine.]
  4. ↑ UniProt, P43121 (англ.) . Архів оригіналу за 12 грудня 2017. Процитовано 8 вересня 2017.

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