Enzyme
Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene .[ 5] [ 6] [ 7] kinase , together with RPS6KA4 , are thought to mediate the phosphorylation of histone H3 , linked to the expression of immediate early genes .[ 8] [ 9]
Interactions
RPS6KA5 has been shown to interact with CREB1 .[ 5] [ 10]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000100784 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021180 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . The EMBO Journal . 17 (15): 4426– 4441. doi :10.1093/emboj/17.15.4426 . PMC 1170775 PMID 9687510 . ^ Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenetics and Cell Genetics . 87 (3– 4): 261– 262. doi :10.1159/000015441 . PMID 10702687 . S2CID 10527498 . ^ "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5" .^ Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, et al. (2003-06-02). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14" . The EMBO Journal . 22 (11): 2788– 2797. doi :10.1093/emboj/cdg273 . ISSN 0261-4189 . PMC 156769 PMID 12773393 . ^ Reul JM, Chandramohan Y (2007-08-01). "Epigenetic mechanisms in stress-related memory formation" Psychoneuroendocrinology . Integrative approaches to neural plasticity (Lille Summer School, 2006). 32 Suppl 1: S21 – S25 . doi :10.1016/j.psyneuen.2007.03.016 . ISSN 0306-4530 . PMID 17644269 . S2CID 24217924 . ^ Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase" . The EMBO Journal . 20 (16): 4370– 4379. doi :10.1093/emboj/20.16.4370 . ISSN 0261-4189 . PMC 125559 PMID 11500364 .
Further reading
Chung J, Uchida E, Grammer TC, Blenis J (Nov 1997). "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation" . Molecular and Cellular Biology . 17 (11): 6508– 6516. doi :10.1128/MCB.17.11.6508 . PMC 232504 PMID 9343414 . Jain N, Zhang T, Fong SL, Lim CP, Cao X (Dec 1998). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)" . Oncogene . 17 (24): 3157– 3167. doi :10.1038/sj.onc.1202238 PMID 9872331 . New L, Zhao M, Li Y, Bassett WW, Feng Y, Ludwig S, et al. (Jan 1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase" . Journal of Biological Chemistry . 274 (2): 1026– 1032. doi :10.1074/jbc.274.2.1026 PMID 9873047 . Thomson S, Clayton AL, Hazzalin CA, Rose S, Barratt MJ, Mahadevan LC (Sep 1999). "The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase" . The EMBO Journal . 18 (17): 4779– 4793. doi :10.1093/emboj/18.17.4779 . PMC 1171550 PMID 10469656 . Lim CP, Cao X (Oct 1999). "Serine phosphorylation and negative regulation of Stat3 by JNK" . Journal of Biological Chemistry . 274 (43): 31055– 31061. doi :10.1074/jbc.274.43.31055 PMID 10521505 . Buck M, Poli V, Geer P, Chojkier M, Hunter T (Dec 1999). "Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha" . Molecular Cell . 4 (6): 1087– 1092. doi :10.1016/S1097-2765(00)80237-3 PMID 10635333 . Lizcano JM, Morrice N, Cohen P (Jul 2000). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155" . The Biochemical Journal . 349 (Pt 2): 547– 557. doi :10.1042/0264-6021:3490547 . PMC 1221178 PMID 10880354 . Hefner Y, Borsch-Haubold AG, Murakami M, Wilde JI, Pasquet S, Schieltz D, et al. (Dec 2000). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases" . Journal of Biological Chemistry . 275 (48): 37542– 37551. doi :10.1074/jbc.M003395200 PMID 10978317 . Arthur JS, Cohen P (Sep 2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells" . FEBS Letters . 482 (1– 2): 44– 48. Bibcode :2000FEBSL.482...44A . doi :10.1016/S0014-5793(00)02031-7 PMID 11018520 . Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, et al. (Jun 2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth" . Journal of Biological Chemistry . 276 (22): 19469– 19482. doi :10.1074/jbc.M009953200 PMID 11297520 . Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR (May 2001). "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3" . The EMBO Journal . 20 (10): 2487– 2496. doi :10.1093/emboj/20.10.2487 . PMC 125453 PMID 11350938 . Liu G, Zhang Y, Bode AM, Ma WY, Dong Z (Mar 2002). "Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation" . Journal of Biological Chemistry . 277 (11): 8810– 8816. doi :10.1074/jbc.M110477200 PMID 11777913 . Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS (Apr 2002). "MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts" . Molecular and Cellular Biology . 22 (8): 2871– 2881. doi :10.1128/MCB.22.8.2871-2881.2002 . PMC 133730 PMID 11909979 . Markou T, Lazou A (Aug 2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase" . The Biochemical Journal . 365 (Pt 3): 757– 763. doi :10.1042/BJ20011828 . PMC 1222733 PMID 11994045 . Toska K, Kleppe R, Armstrong CG, Morrice NA, Cohen P, Haavik J (Nov 2002). "Regulation of tyrosine hydroxylase by stress-activated protein kinases" . Journal of Neurochemistry . 83 (4): 775– 783. doi :10.1046/j.1471-4159.2002.01172.x PMID 12421349 . Janknecht R (Feb 2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene . 22 (5): 746– 755. doi :10.1038/sj.onc.1206185 . PMID 12569367 . S2CID 30183941 . Dolled-Filhart M, Camp RL, Kowalski DP, Smith BL, Rimm DL (Feb 2003). "Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis". Clinical Cancer Research . 9 (2): 594– 600. PMID 12576423 .
Activity Regulation Classification Kinetics Types
