RPS6KA5
Enzyme
Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene .[ 5] [ 6] [ 7] kinase , together with RPS6KA4 , are thought to mediate the phosphorylation of histone H3 , linked to the expression of immediate early genes .[ 8] [ 9]
Interactions
RPS6KA5 has been shown to interact with CREB1 .[ 5] [ 10]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000100784 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021180 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . EMBO J . 17 (15): 4426– 41. doi :10.1093/emboj/17.15.4426 . PMC 1170775 PMID 9687510 . ^ Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenet Cell Genet . 87 (3– 4): 261– 2. doi :10.1159/000015441 . PMID 10702687 . S2CID 10527498 . ^ "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5" .^ Soloaga, Ana; Thomson, Stuart; Wiggin, Giselle R.; Rampersaud, Navita; Dyson, Mark H.; Hazzalin, Catherine A.; Mahadevan, Louis C.; Arthur, J.Simon C. (2003-06-02). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14" . The EMBO Journal . 22 (11): 2788– 2797. doi :10.1093/emboj/cdg273 . ISSN 0261-4189 . PMC 156769 PMID 12773393 . ^ Reul, Johannes M. H. M.; Chandramohan, Yalini (2007-08-01). "Epigenetic mechanisms in stress-related memory formation" . Psychoneuroendocrinology . Integrative approaches to neural plasticity (Lille Summer School, 2006). 32 : S21 – S25 . doi :10.1016/j.psyneuen.2007.03.016 . ISSN 0306-4530 . PMID 17644269 . S2CID 24217924 . ^ Wang, X; Li W; Williams M; Terada N; Alessi D R; Proud C G (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase" . EMBO J . 20 (16): 4370– 9. doi :10.1093/emboj/20.16.4370 . ISSN 0261-4189 . PMC 125559 PMID 11500364 .
Further reading
Chung J, Uchida E, Grammer TC, Blenis J (1997). "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation" . Mol. Cell. Biol . 17 (11): 6508– 16. doi :10.1128/MCB.17.11.6508 . PMC 232504 PMID 9343414 . Jain N, Zhang T, Fong SL, et al. (1999). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)" . Oncogene . 17 (24): 3157– 67. doi :10.1038/sj.onc.1202238 PMID 9872331 . New L, Zhao M, Li Y, et al. (1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase" . J. Biol. Chem . 274 (2): 1026– 32. doi :10.1074/jbc.274.2.1026 PMID 9873047 . Thomson S, Clayton AL, Hazzalin CA, et al. (1999). "The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase" . EMBO J . 18 (17): 4779– 93. doi :10.1093/emboj/18.17.4779 . PMC 1171550 PMID 10469656 . Lim CP, Cao X (1999). "Serine phosphorylation and negative regulation of Stat3 by JNK" . J. Biol. Chem . 274 (43): 31055– 61. doi :10.1074/jbc.274.43.31055 PMID 10521505 . Buck M, Poli V, van der Geer P, et al. (2000). "Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha" . Mol. Cell . 4 (6): 1087– 92. doi :10.1016/S1097-2765(00)80237-3 PMID 10635333 . Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155" . Biochem. J . 349 (Pt 2): 547– 57. doi :10.1042/0264-6021:3490547 . PMC 1221178 PMID 10880354 . Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases" . J. Biol. Chem . 275 (48): 37542– 51. doi :10.1074/jbc.M003395200 PMID 10978317 . {{cite journal }}: CS1 maint: numeric names: authors list (link )Arthur JS, Cohen P (2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells" . FEBS Lett . 482 (1– 2): 44– 8. doi :10.1016/S0014-5793(00)02031-7 PMID 11018520 . Sapkota GP, Kieloch A, Lizcano JM, et al. (2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth" . J. Biol. Chem . 276 (22): 19469– 82. doi :10.1074/jbc.M009953200 PMID 11297520 . Deb A, Zamanian-Daryoush M, Xu Z, et al. (2001). "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3" . EMBO J . 20 (10): 2487– 96. doi :10.1093/emboj/20.10.2487 . PMC 125453 PMID 11350938 . Liu G, Zhang Y, Bode AM, et al. (2002). "Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation" . J. Biol. Chem . 277 (11): 8810– 6. doi :10.1074/jbc.M110477200 PMID 11777913 . Wiggin GR, Soloaga A, Foster JM, et al. (2002). "MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts" . Mol. Cell. Biol . 22 (8): 2871– 81. doi :10.1128/MCB.22.8.2871-2881.2002 . PMC 133730 PMID 11909979 . Markou T, Lazou A (2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase" . Biochem. J . 365 (Pt 3): 757– 63. doi :10.1042/BJ20011828 . PMC 1222733 PMID 11994045 . Toska K, Kleppe R, Armstrong CG, et al. (2002). "Regulation of tyrosine hydroxylase by stress-activated protein kinases" . J. Neurochem . 83 (4): 775– 83. doi :10.1046/j.1471-4159.2002.01172.x PMID 12421349 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Janknecht R (2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene . 22 (5): 746– 55. doi :10.1038/sj.onc.1206185 . PMID 12569367 . S2CID 30183941 . Dolled-Filhart M, Camp RL, Kowalski DP, et al. (2003). "Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis". Clin. Cancer Res . 9 (2): 594– 600. PMID 12576423 .
Activity Regulation Classification Kinetics Types
