MKNK2

MKNK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMKNK2, GPRK7, MNK2, MAP kinase interacting serine/threonine kinase 2, MAPK interacting serine/threonine kinase 2
External IDsOMIM: 605069; MGI: 894279; HomoloGene: 49674; GeneCards: MKNK2; OMA:MKNK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2872

17347

Ensembl

ENSG00000099875

ENSMUSG00000020190

UniProt

Q9HBH9

Q8CDB0

RefSeq (mRNA)

NM_199054
NM_017572

NM_021462

RefSeq (protein)

NP_060042
NP_951009

NP_067437

Location (UCSC)Chr 19: 2.04 – 2.05 MbChr 10: 80.5 – 80.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.[5][6]

Interactions

MNK2 has been shown to interact with MAPK1[7][8] and Eukaryotic translation initiation factor 4 gamma.[7]

MNK2 has been identified as a therapeutic target for diabetes. Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099875 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020190 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (October 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics. 69 (1): 63–71. doi:10.1006/geno.2000.6299. PMID 11013076.
  6. ^ "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2".
  7. ^ a b Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG (August 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Molecular and Cellular Biology. 23 (16): 5692–5705. doi:10.1128/MCB.23.16.5692-5705.2003. PMC 166352. PMID 12897141.
  8. ^ Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (April 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". The EMBO Journal. 16 (8): 1909–1920. doi:10.1093/emboj/16.8.1909. PMC 1169794. PMID 9155017.
  9. ^ Karampelias C, Watt K, Mattsson CL, Ruiz ÁF, Rezanejad H, Mi J, et al. (September 2022). "MNK2 deficiency potentiates β-cell regeneration via translational regulation". Nature Chemical Biology. 18 (9): 942–953. doi:10.1038/s41589-022-01047-x. PMC 7613404. PMID 35697798.

Further reading

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