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CDKL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AAA, 4BBM
Identifiers
Aliases	CDKL2, KKIAMRE, P56, cyclin dependent kinase like 2
External IDs	OMIM: 603442; MGI: 1858227; HomoloGene: 55793; GeneCards: CDKL2; OMA:CDKL2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	75,630,716 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	92,043,883 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; postcentral gyrus; ; superior frontal gyrus; ; testicle; ; primary visual cortex; ; entorhinal cortex; ; lower lobe of lung; ; prefrontal cortex;
	Top expressed in
	barrel cortex; ; lumbar spinal ganglion; ; spermatocyte; ; facial motor nucleus; ; seminiferous tubule; ; olfactory epithelium; ; spermatid; ; vestibular sensory epithelium; ; zygote; ; Epithelium of choroid plexus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein serine/threonine kinase activity; ATP binding; kinase activity; cyclin-dependent protein serine/threonine kinase activity;
Cellular component	cytoplasm; centrosome; nucleus;
Biological process	protein phosphorylation; sex differentiation; phosphorylation; signal transduction; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	8999
	53886
	ENSG00000138769
	ENSMUSG00000029403
	Q92772
	Q9QUK0
	NM_003948; NM_001330724
	NM_001276315; NM_016912; NM_177270
	NP_001317653; NP_003939
	NP_001263244; NP_058608; NP_796244
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.^[5]^[6]

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138769 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029403 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene. 13 (12): 2563–74. PMID 9000130.
^ ^a ^b "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)".

External links

Human CDKL2 genome location and CDKL2 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q92772 (Cyclin-dependent kinase-like 2) at the PDBe-KB.

Marracci GH, Marquardt WE, Strehlow A, et al. (2006). "Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck)". Biochem. Biophys. Res. Commun. 344 (3): 963–971. doi:10.1016/j.bbrc.2006.03.172. PMID 16631599.
Sarkar SN, Peters KL, Elco CP, et al. (2004). "Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling". Nat. Struct. Mol. Biol. 11 (11): 1060–1067. doi:10.1038/nsmb847. PMID 15502848. S2CID 6869429.
Tao J, Van Esch H, Hagedorn-Greiwe M, et al. (2005). "Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation". Am. J. Hum. Genet. 75 (6): 1149–1154. doi:10.1086/426460. PMC 1182152. PMID 15499549.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC (1995). "Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors". J. Biol. Chem. 270 (16): 9115–9120. doi:10.1074/jbc.270.16.9115. PMID 7721825.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138769 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029403 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9000130-5] Taglienti CA, Wysk M, Davis RJ (Feb 1997). "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE". Oncogene. 13 (12): 2563–74. PMID 9000130.

[entrez-6] "Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)".

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CDKL2

References

External links

Further reading